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ALXN2230

Phase 1

Healthy Adult Participants | Small molecule | Other |AstraZeneca PLC|Last Updated: Apr 9, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment48

FDA Designations

No designations recorded

Clinical trial landscape

ALXN2230 · 1 trial · 1 indication

Phase 1 1
NCT07352423Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of ALXN2230 in Healthy ParticipantsHealthy Adult Participants
RECRUITING48 Analytics
PHASE1RECRUITING
Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of ALXN2230 in Healthy Participants
Healthy Adult ParticipantsUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with Treatment-emergent Adverse Events (TEAEs) and Treatment-emergent Serious Adverse Events (TESAEs)
Day 1 up to Day 113

Secondary Endpoints

Maximum Observed Serum Concentration (Cmax) of ALXN2230
Day 1 up to Day 113
Time to Cmax (Tmax) of ALXN2230
Day 1 up to Day 113
Area Under the Concentration-time Curve from Time 0 to the Last Quantifiable Concentration (AUCt) of ALXN2230
Day 1 up to Day 113
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
PlaceboPLACEBO_COMPARATORParticipants will be enrolled across multiple cohorts and will receive a single dose of placebo.
ALXN2230EXPERIMENTALParticipants will be enrolled across multiple cohorts and will receive a single dose of ALXN2230.

Interventions

NameTypeDescription
ALXN2230DRUGParticipants will receive ALXN2230 via SC injection. Optional cohort will receive ALXN2230 via SC infusion.
PlaceboDRUGParticipants will receive placebo via SC injection. Optional cohort will receive placebo via SC infusion.
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Participants who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring. * Baseline immunoglobulin G (IgG) concentrations ≥ 1000 milligrams per deciliter (mg/dL) and ≤ 1600 mg/dL at Scre...

Countries:United Kingdom
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Frequently asked questions about ALXN2230

What is ALXN2230 used for?

ALXN2230 is an investigational small molecule being studied in healthy adult participants. It is currently in Phase 1 clinical development, and its safety, tolerability, pharmacokinetics, and pharmacodynamics are being evaluated in a clinical trial.

Who makes ALXN2230?

ALXN2230 is being developed by AstraZeneca PLC, which is listed on the stock exchange under the ticker symbol AZN. The company is conducting a Phase 1 clinical trial to evaluate the drug in healthy participants.

What phase is ALXN2230 in?

ALXN2230 is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. A Phase 1 study is currently recruiting participants to assess its safety and tolerability.

What clinical trials is ALXN2230 in?

ALXN2230 is being studied in a Phase 1 clinical trial with the identifier NCT07352423. This randomized, double-blind, placebo-controlled study is evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALXN2230 in healthy adult participants in the United Kingdom.

Is ALXN2230 FDA approved?

ALXN2230 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development. The ongoing trial is designed to evaluate its safety and tolerability in healthy participants, and it has not yet been studied in patients with any disease.