Recent Updates
Recently added Catalysts

5-flourouracil

Phase 2

Squamous Cell Cancer | Small molecule | Oncology |AstraZeneca PLC|Last Updated: Apr 23, 2009

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedUNCONTROLLED
Total Trials1
Total Enrollment64

FDA Designations

No designations recorded

Clinical trial landscape

5-flourouracil · 1 trial · 2 indications

Phase 2 1
NCT00255476The IRESSA Novel Head and Neck Chemotherapy Evaluation StudySquamous Cell Cancer
COMPLETED64 Analytics
PHASE2COMPLETED
The IRESSA Novel Head and Neck Chemotherapy Evaluation Study
Squamous Cell CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

To compare the objective tumour response rate between cisplatin/5FU and cisplatin/5FU and ZD1839 combination in these patients

Secondary Endpoints

To compare safety and tolerability in these patients
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
gefitinibDRUG -
cisplatinDRUG -
5-flourouracilDRUG -
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Provision of written informed consent * Patients with histologically proven primary SCCHN * Aged 18 or over Exclusion Criteria: * Patients eligible for surgery with curative intent * Other co-existing malignancies diagnosed within the last 5 years with the exception of basal...

Countries:United Kingdom
Unlock Eligibility Criteria

Frequently asked questions about 5-flourouracil

What is 5-flourouracil used for?

5-flourouracil is used for squamous cell cancer, including cancer of the head and neck. It is being studied in a Phase 2 clinical trial for these conditions. The drug is an oncology small molecule being developed by AstraZeneca PLC.

Who makes 5-flourouracil?

AstraZeneca PLC (ticker: AZN) is developing 5-flourouracil. The company is conducting a Phase 2 clinical trial of the drug for squamous cell cancer and head and neck cancer. The trial is completed and enrolled 64 participants.

What phase is 5-flourouracil in?

5-flourouracil is in Phase 2 clinical development. It is an investigational drug being studied for squamous cell cancer and head and neck cancer. The Phase 2 trial has been completed, and the drug is not yet approved for any use.

What clinical trials is 5-flourouracil in?

5-flourouracil is associated with one completed Phase 2 trial, NCT00255476, titled "The IRESSA Novel Head and Neck Chemotherapy Evaluation Study." The trial enrolled 64 participants with squamous cell cancer and head and neck cancer in the United Kingdom.

Is 5-flourouracil the same as IRESSA?

5-flourouracil is not the same as IRESSA. The clinical trial NCT00255476, which studies 5-flourouracil, is named the IRESSA Novel Head and Neck Chemotherapy Evaluation Study. IRESSA is a separate drug being evaluated in combination with 5-flourouracil in this trial.