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AstraZeneca PLC

AZNFDA catalysts, PDUFA dates & pipeline intelligence
$172.06
▲ +0.57 · +0.33%

Financials

Last updated
Revenue
R&D Expenses
Operating CF
Total Assets
Total Liabilities
Equity
Shares Out.
D/E Ratio
Quarterly Cash
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52W LOW $153.4152W HIGH $212.71
Volume
4.13 M
Value Traded
605.23 M
Short % Float
0.17%
Days to Cover
1.0
+4.95%Week
+3.56%1 Month
+1.43%3 Month
-8.24%6 Month
+64.22%5 Year
+368.75%All Time

Cash Data

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  • Cash FlowProfitable
  • SEC Filing

Key Stats

Market Cap
266.85 B
EPS (TTM)
6.61
P/E Ratio
26.04
Ent. Value
301.56 B
Total Shares
1.55 B
Float Shares
1.50 B
Insiders
3.44%
Institutions
60.80%

Upcoming Catalysts

FDA decisions, readouts and PDUFA dates · scored by probability of approval

Catalyst Drug / Treatment Stage Prob. of Approval Description Drug Type Therapeutic Area Source
Phase 1 data presentation
C-CAR031 (GPC3-targeted CAR-T)
advanced hepatocellular carcinoma (aHCC)
Phase 1Cell TherapiesOncology
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Every FDA decision, readout and PDUFA date, with drug type, therapeutic area and a PoA score you can trade on.
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PoA blends historical approval base rates, trial design score and FDA review track record.

AZN Catalyst Timeline

Dated clinical, regulatory and corporate events for AstraZeneca PLC

Catalyst Timeline

Dated clinical, regulatory & corporate events for AstraZeneca PLC

143Total events
16Upcoming
90Tier-1 (high impact)
2023 to 2027Coverage

Upcoming catalysts 2

T2Product Launch
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ZEGFROVYApproved
T2Oral Presentation
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Savolitinib

Event history 50

◆Oral PresentationPresentation
DESTINY-Breast11 MRI-assessed objective response data presented at ESMO 2026
HER2+ early breast cancersource ↗
◆Oral PresentationCapivasertibApprovedPresentation
CAPItello-281 updated overall survival data presented at ESMO 2026
PTEN-deficient metastatic hormone sensitive prostate cancersource ↗
▲Partnership / LicenseCorporate
insitro enters worldwide exclusive research collaboration with AstraZeneca for MASH and cardiomyopathies
MASH and cardiomyopathiessource ↗
▲Manufacturing MilestoneCMC / Inspection
AstraZeneca opens new global strategic R&D center in Kendall Square, Cambridge, Massachusetts
▲Partnership / LicenseCorporate
Daiichi Sankyo and AstraZeneca enter clinical trial collaboration with Summit Therapeutics to evaluate Datroway plus ivonescimab
multiple tumor types including lung and breast cancerssource ↗
▲Milestone PaymentElecoglipronCorporate
Eccogene receives $50M milestone payment from AstraZeneca
▲Partnership / LicenseCorporate
Susan G. Komen and AstraZeneca announce Navigation Infrastructure Collaboration partnership
breast cancersource ↗
▲Partnership / LicenseZEGFROVYApprovedCorporate
AstraZeneca completes global license agreement with Dizal for ZEGFROVY (sunvozertinib)
lung cancersource ↗
▲Trial InitiationElecoglipronTrial
Initiation of Elevate Phase 3 outcome trials of elecoglipron in HFmrEF/HFpEF and CKD
heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) and chronic kidney disease (CKD)source ↗
▲Quarterly UpdateCorporate
AstraZeneca reported H1 and Q2 2026 financial results
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Every PDUFA date, readout, approval and corporate move, tiered by market impact and updated daily.
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Past FDA Catalysts and PDUFA Decisions

How AZN actually traded into and out of each decision

Date Drug Catalyst Stage Reaction Event Move % Best Trade %
2026-10-25IMFINZI combinations with datopotamab deruxtecan (DATROWAY), oleclumab and monalizumab Phase 2 data presentation Phase 2
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Reaction: 30 trading days around the event · Event Move: close to close on decision day · Best Trade: peak run-up from entry 10 days before the decision

Drug Pipeline Intelligence

Pipeline Score
Pipeline Value
Commercial Value
Valuation Signal
149
Drugs Scored
rNPV / MCap
Top Drug
Top 1%
Large Pharma
(rank 8 of 657)
Percentile Rank
Commercial products (revenue basis: trailing 4 quarters of total revenue (20-F and 6-K), to Jun 2026; product lines: last four quarters to Jun 2026 (20-F and 6-K))
ProductRevenuePrior periodChange
Farxiga
Tagrisso
Imfinzi
Ultomiris
Calquence
Lynparza
Symbicort
Fasenra
Strensiq
Soliris
Breztri
Crestor
Top 12 of 30 product lines shown.
Showing 94 of 1423 assets
DrugIndicationPhasePTRSrNPVStatusEnrollVelocityDesignEst. CompletionML SignalLast Change
Elecoglipron Small moleculeNCT07662044Type 2 Diabetes MellitusPhase 3 RECRUITING 5,500Jul 14, 2028
Elecoglipron Small moleculeNCT07667803Weight ManagementPhase 3 RECRUITING 4,500Jul 30, 2029
Elecoglipron Small moleculeNCT07775404ObesityPhase 3 RECRUITING 351Apr 13, 2028
Elecoglipron Small moleculeNCT07753993Chronic Kidney DiseasePhase 3 RECRUITING 7,000Oct 4, 2030
Elecoglipron Small moleculeNCT07761117Heart Failure With Preserved Ejection Fraction (HFpEF)Phase 3 RECRUITING 6,950Sep 3, 2029
Datopotamab deruxtecan ADCNCT05687266NSCLCPhase 3 ACTIVE NOT_RECRUITING 1,350Nov 1, 2027
Dato-DXd ADCNCT06417814Metastatic Non-small Cell Lung CancerPhase 3 ACTIVE NOT_RECRUITING 768Sep 27, 2028
Datopotamab deruxtecan ADCNCT05215340Metastatic Non Small Cell Lung CancerPhase 3 RECRUITING 740Apr 30, 2028
Dato-DXd ADCNCT07720284High-risk Muscle Invasive Urothelial CarcinomaPhase 3 RECRUITING 915Nov 23, 2032
Datopotamab deruxtecan ADCNCT06564844Non-small Cell Lung CancerPhase 3 ACTIVE NOT_RECRUITING 1,100Mar 31, 2027
Datopotamab deruxtecan ADCMarketedNCT07069595Breast CancerPhase 2 RECRUITING 78Nov 1, 2032
Datopotamab deruxtecan ADCNCT05489211Endometrial CancerPhase 2 RECRUITING 454Oct 1, 2027
Dato-DXd ADCNCT07129993Urothelial CancerPhase 2 RECRUITING 630Jan 22, 2030
Datopotamab deruxtecan ADCNCT05460273Carcinoma, Non-Small-Cell LungPhase 1 ACTIVE NOT_RECRUITING 119Jun 30, 2027
Datopotamab deruxtecan ADCNCT04612751Advanced or Metastatic NSCLCPhase 1 ACTIVE NOT_RECRUITING 155May 4, 2027
AZD0780 Small moleculeNCT07000136Heterozygous Familial HypercholesterolaemiaPhase 3 ACTIVE NOT_RECRUITING 473Jan 4, 2027
Laroprovstat Small moleculeNCT07619118HypercholesterolaemiaPhase 3 RECRUITING 800May 28, 2027
AZD0780 Small moleculeNCT07000123Cardiovascular DiseasePhase 3 ACTIVE NOT_RECRUITING 18,211Jan 11, 2027
Rilvegostomig Monoclonal antibodyNCT06868277Carcinoma, Non-Small Cell LungPhase 3 RECRUITING 830Dec 2, 2030
Volrustomig Monoclonal antibodyNCT06943833Locally Advanced Cervical CancerPhase 3 ACTIVE NOT_RECRUITING 837Mar 13, 2029
Volrustomig Small moleculeNCT05984277Metastatic Non-small Cell Lung CancerPhase 3 ACTIVE NOT_RECRUITING 895Nov 12, 2027
Rilvegostomig Small moleculeNCT06627647Non-squamous Non-small Cell Lung CancerPhase 3 RECRUITING 1,160Nov 18, 2030
Rilvegostomig Small moleculeNCT07098338Non-Small Cell Lung CancerPhase 3 RECRUITING 1,438Apr 6, 2029
Rilvegostomig Small moleculeNCT06764875HER2-positive Gastric CancerPhase 3 RECRUITING 840Dec 9, 2030
Saruparib Small moleculeNCT06380751Advanced Breast CancerPhase 3 RECRUITING 788Dec 30, 2031
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PTRS, rNPV, enrollment velocity, trial design quality and ML risk signals for every asset above.
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Clinical Trial Results

Readouts, endpoints and source filings for every AZN program

Drug Name Indication Phase Date Trial Results SummaryTitleSource
Sone-Ve CLDN18.2-positive gastric cancerPhase 32026-10-19statistically significant and clinically meaningful overall survival (OS) benefitRead MoreAstraZeneca to present overall survival data from four pivotal Phase III trials in Presidential Symposia at ESMO 2026 featuring Sone-Ve, IMFINZI® (durvalumab), TAGRISSO® (osimertinib) and savolitinibRead More
Scroll for more · summaries link to the source press release
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Inside Trades

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Monthly insider buys and sells against the stock price, with the insider sentiment reading.
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InsiderSideSharesPriceValueDate
Sharma ManiOfficer (See Remarks)Buy 20.233 19,287.699 held$160.57 08/08/2026
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Hedge Fund 13F Activity

Fund % of Portfolio Current MV Shares Owned Activity
ORBIMED ADVISORS LLC 3.2 % (23.1 %) 171.08 M 915.70 K 36.63% ( 245.50 K)
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Shares held by hedge funds each quarter, and who bought or sold.

AZN Institutional Ownership Trends

AZN Short Interest

Shares sold short, counted twice a month.

0.17%
Short % of Float
of tradable shares sold short
2.6M
Shares Sold Short
+25.4% vs prior count
1.0 Low
Days to Cover
trading days of normal volume to buy every short share back
2.8M
Avg Daily Volume
the average used for days to cover
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Two years of days to cover and shares sold short, with every count and its change.
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Options Data

Option Volume

Open Interest
Call OI
Put OI
Put-Call Ratio
OI 30-day avg
Today vs avg
Option Volume
Call Vol
Put Vol
Put-Call Ratio
Vol 30-day avg
Today vs avg

Option Chain Statistics

ExpiryCall VolPut VolVol P/CCall OIPut OIOI P/CIV CallIV Call OI-WtdIV Call Vol-WtdIV PutIV Put OI-WtdIV Put Vol-Wtd
2026-11-20
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Per-expiry call and put volume, open interest, put-call ratios and implied volatility.
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Real-Time Option Chain

CallsStrikePuts
LastVolOILastVolOI
No data available
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Calls vs Puts by Expiry

CallsPutsLog scale
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Competitive positioning

How AZN ranks across every disease it competes in

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See how AZN ranks against every competitor across each disease it develops in: phase, best drug, trials and likelihood of approval.
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AZN News

AZN
Oct 19, 2026
AZNConferences/Events

AstraZeneca to present overall survival data from four pivotal Phase III trials in Presidential Symposia at ESMO 2026 featuring Sone-Ve, IMFINZI® (durvalumab), TAGRISSO® (osimertinib) and savolitinib

AstraZeneca will present pivotal Phase III trial data at the ESMO Congress 2026, showcasing promising results for several cancer treatments. Key highlights include the CLARITY-Gastric01 trial of Sone-Ve, which shows significant overall survival benefits for gastric cancer patients, and the SAFFRON trial, demonstrating the efficacy of TAGRISSO combined with savolitinib for lung cancer. The findings suggest a transformative potential for combination therapies in improving patient outcomes across various cancer types.

Read more →
AZN
Oct 15, 2026
AZNGeneral

insitro Announces a Strategic Collaboration with AstraZeneca for AI-enabled Discovery of Novel Therapeutics for MASH and Cardiomyopathies

insitro has entered a strategic collaboration with AstraZeneca to leverage its AI platform for discovering new therapeutics targeting metabolic dysfunction-associated steatohepatitis (MASH) and cardiomyopathies. The agreement includes an upfront payment of $40 million and potential milestones totaling approximately $1.46 billion. AstraZeneca will oversee clinical development and commercialization, aiming to address the complexities of these underdiagnosed diseases.

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AZN
Oct 5, 2026
AZNGeneral

AstraZeneca opens new global strategic R&D center in Kendall Square, Cambridge, Massachusetts

AstraZeneca has inaugurated a new global strategic R&D center in Kendall Square, Cambridge, Massachusetts. This facility strengthens the company's existing presence in the area and aims to foster innovation by placing scientists in a leading life sciences ecosystem. The center is expected to enhance collaboration in genomic medicine and other research areas.

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AZN
Oct 2, 2026
AZNPhases

Daiichi Sankyo and AstraZeneca Enter into Clinical Trial Collaboration with Summit Therapeutics to Evaluate Datroway® in Combination with Ivonescimab Across Multiple Tumor Types

Daiichi Sankyo and AstraZeneca have formed a clinical trial collaboration with Summit Therapeutics to assess the efficacy of Datroway® in combination with ivonescimab across various tumor types, including lung and breast cancers. The collaboration will commence with a phase 3 trial focusing on first-line treatment for triple negative breast cancer. This partnership aims to enhance treatment options for patients with these cancers.

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AZN
Sep 28, 2026
AZNPhases

Eccogene Receives $50 Million Milestone Payment from AstraZeneca Following Initiation of Global Phase 3 Program for Elecoglipron (AZD5004/ECC5004)

Eccogene has received a $50 million milestone payment from AstraZeneca following the initiation of a Global Phase 3 program for Elecoglipron (AZD5004/ECC5004). This payment marks a significant step in the development of the drug, showcasing the partnership's progress. The Phase 3 program is crucial for the drug's potential approval and market entry.

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AZN
Sep 23, 2026
AZNGeneral

Polaris Rx Named Exclusive U.S. Distributor of AstraZeneca's FluMist® Home Service for Second Consecutive Year

Polaris Rx has been named the exclusive U.S. distributor for AstraZeneca's FluMist Home service for the 2026-2027 flu season, marking the second consecutive year of this partnership. This service allows individuals to conveniently order the flu vaccine online and have it delivered directly to their homes. The collaboration aims to improve access to flu vaccinations.

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AZN
Sep 14, 2026
AZNGeneral

Susan G. Komen® and AstraZeneca Partnership to Make Patient Navigation Available to All

Susan G. Komen has partnered with AstraZeneca to enhance patient navigation in breast cancer care. This initiative aims to integrate patient navigation into the national healthcare system, addressing barriers and improving access to timely treatments. The collaboration seeks to reduce patient stress and enhance adherence to cancer care plans across the nation.

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AZN
Sep 1, 2026
AZNGeneral

AstraZeneca completes global license agreement for oral EGFR inhibitor ZEGFROVY® (sunvozertinib) for lung cancer

AstraZeneca has finalized a global license agreement with Dizal Pharmaceutical for ZEGFROVY (sunvozertinib), an oral EGFR inhibitor for lung cancer. This agreement grants AstraZeneca worldwide rights to develop and commercialize the drug, which is already approved in the US and China for second-line treatment in adults.

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AZN
Jul 27, 2026
AZNGeneral

AstraZeneca results: H1 and Q2 2026

AstraZeneca reported strong financial results for H1 2026, with total revenue increasing by 9% compared to the previous year. Product sales reached $28.9 billion, reflecting an 8% growth. The company's core EPS also showed a positive trend, rising by 12%. However, collaboration revenue experienced a decline of 6%. Overall, the results indicate a solid performance despite some challenges.

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AZN
Jul 14, 2026
AZNGeneral

Dizal Announces Global Exclusive License Agreement with AstraZeneca for Zegfrovy

Dizal has entered a global exclusive license agreement with AstraZeneca for Zegfrovy, an EGFR inhibitor for lung cancer. The deal includes a $600M upfront payment and potential milestone payments of up to $900M. Zegfrovy is already approved in China and the US for treating advanced NSCLC with specific mutations. AstraZeneca aims to leverage its oncology expertise to expand Zegfrovy's reach.

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AZN
Jul 7, 2026
AZNGeneral

Helix Announces Multi-Year Agreement with AstraZeneca to Support Genomic Research for Drug Discovery and Development

Helix has entered a multi-year agreement with AstraZeneca to provide access to its GenoSphere cohorts, which include extensive genomic and clinical data. This collaboration aims to enhance drug discovery and development by leveraging integrated clinico-genomic data. The partnership is expected to accelerate biomedical research and improve the development of targeted therapies.

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AZN
Jul 2, 2026
AZNPhases
▲ +6.1%on this newsshared move

Abbisko Therapeutics and AstraZeneca Enter a Strategic Collaboration to Conduct the Clinical Trial of Lumipodlin (ABSK043), a First-in-Class Oral PD-L1 Inhibitor, in Combination with TAGRISSO® for NSCLC

Abbisko Therapeutics has partnered with AstraZeneca to conduct a Phase I/II clinical trial for lumipodlin (ABSK043), an oral PD-L1 inhibitor, in combination with TAGRISSO® for treating non-small cell lung cancer (NSCLC). The trial aims to evaluate the safety and efficacy of this novel therapy for patients with EGFR mutations and high PD-L1 expression. The IND application for the study was recently approved by the National Medical Products Administration.

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AZN
Jun 24, 2026
AZNGeneral

AstraZeneca and YMCA of the USA Announce Landmark Partnership Aimed to Address Gaps in Cancer Care

AstraZeneca has formed a partnership with YMCA of the USA to tackle disparities in cancer care. This collaboration aims to enhance accessibility and improve health outcomes for communities. The initiative is expected to address critical gaps in healthcare services related to cancer treatment and support.

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AZN
Jun 9, 2026
AZNGeneral

Lung Cancer Research Foundation and AstraZeneca Announce Open Call for Research Proposals with Focus on Small Cell Lung Cancer

The Lung Cancer Research Foundation and AstraZeneca have announced two research awards aimed at improving treatment outcomes for small cell lung cancer (SCLC). The awards, totaling $750,000, will support innovative strategies and patient advocacy efforts. Submissions for research proposals are open until July 15, 2026, with the goal of advancing understanding and treatment of this challenging cancer.

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AZN
May 22, 2026
AZNFDA Updates

Datroway® Approved in the U.S. as First TROP2 Directed Antibody Drug Conjugate for First-Line Treatment of Patients with Metastatic Triple Negative Breast Cancer Who Are Not PD-1/PD-L1 Inhibitor Candidates

Datroway® has received U.S. approval as the first TROP2 directed antibody drug conjugate. It is intended for first-line treatment of patients with metastatic triple negative breast cancer who are not eligible for PD-1/PD-L1 inhibitors. This approval marks a significant advancement in treatment options for this patient population.

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AZN
May 18, 2026
AZNGeneral

AstraZeneca Collaborates with Roche Diagnostics Asia Pacific to Help Accelerate Sustainable Ecosystem for Advanced Pathology in Breast and Lung Cancer

AstraZeneca and Roche Diagnostics Asia Pacific have entered a three-year Memorandum of Understanding to enhance digital pathology capabilities across nine Asian markets. This collaboration aims to improve biomarker testing for breast and lung cancer through AI-powered solutions and educational initiatives. The partnership addresses significant gaps in diagnostic processes and aims to standardize and improve cancer care.

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AZN
May 1, 2026
AZNFDA Updates

TRUQAP® (capivasertib) recommended by FDA Advisory Committee for PTEN-deficient metastatic hormone-sensitive prostate cancer

The FDA's Oncologic Drugs Advisory Committee has recommended AstraZeneca's TRUQAP (capivasertib) in combination with abiraterone and ADT for PTEN-deficient metastatic hormone-sensitive prostate cancer. This recommendation is based on favorable results from the CAPItello-281 Phase III trial, which demonstrated a significant reduction in disease progression. The treatment addresses a critical need for patients with limited options and is the first targeted therapy for this cancer subtype.

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AZN
Mar 9, 2026
AZNFDA Updates

Koselugo approved in Canada for plexiform neurofibromas in adults with neurofibromatosis type 1

Koselugo (selumetinib) has been approved in Canada for adults with neurofibromatosis type 1 (NF1) suffering from symptomatic, inoperable plexiform neurofibromas. This approval follows positive results from the KOMET Phase III trial, which showed a 20% objective response rate in tumor size reduction. Experts highlight the significance of this treatment option for patients who previously had limited therapeutic choices.

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AZN
Mar 9, 2026
AZNFDA Updates

ENHERTU® Granted Priority Review in the U.S. as Post-Neoadjuvant Treatment for Patients with HER2 Positive Early Breast Cancer

AstraZeneca and Daiichi Sankyo's ENHERTU has received Priority Review from the FDA for treating HER2 positive early breast cancer patients with residual disease after neoadjuvant therapy. The decision follows promising results from the DESTINY-Breast05 trial, which demonstrated a significant reduction in disease recurrence. The FDA's target action date for this application is July 7, 2026.

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AZN
Feb 24, 2026
AZNGeneral

SECURITIES AND EXCHANGE COMMISSION

AstraZeneca PLC has filed a report with the SEC for February 2026, according to the requirements set forth by the Securities Exchange Act of 1934. The filing includes details about the registrant’s annual financial report and compliance with various regulatory requirements. This follows standard practice for foreign issuers under SEC regulations.

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About AstraZeneca PLC

96,100 employees astrazeneca.com
HeadquartersCambridge
Founded1913
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