Financials
Cash Data
- Cash FlowProfitable
- SEC Filing
Key Stats
Upcoming Catalysts
FDA decisions, readouts and PDUFA dates · scored by probability of approval
AZN Catalyst Timeline
Dated clinical, regulatory and corporate events for AstraZeneca PLC
Catalyst Timeline
Dated clinical, regulatory & corporate events for AstraZeneca PLC
Upcoming catalysts 2
Event history 50
Past FDA Catalysts and PDUFA Decisions
How AZN actually traded into and out of each decision
| Date | Drug | Catalyst | Stage | Reaction | Event Move % | Best Trade % |
|---|---|---|---|---|---|---|
| 2026-10-25 | IMFINZI combinations with datopotamab deruxtecan (DATROWAY), oleclumab and monalizumab | Phase 2 data presentation | Phase 2 |
Drug Pipeline Intelligence
| Product | Revenue | Prior period | Change |
|---|---|---|---|
| Farxiga | |||
| Tagrisso | |||
| Imfinzi | |||
| Ultomiris | |||
| Calquence | |||
| Lynparza | |||
| Symbicort | |||
| Fasenra | |||
| Strensiq | |||
| Soliris | |||
| Breztri | |||
| Crestor |
| Drug | Indication | Phase | PTRS | rNPV | Status | Enroll | Velocity | Design | Est. Completion | ML Signal | Last Change |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Elecoglipron Small moleculeNCT07662044 | Type 2 Diabetes Mellitus | Phase 3 | RECRUITING | 5,500 | Jul 14, 2028 | ||||||
| Elecoglipron Small moleculeNCT07667803 | Weight Management | Phase 3 | RECRUITING | 4,500 | Jul 30, 2029 | ||||||
| Elecoglipron Small moleculeNCT07775404 | Obesity | Phase 3 | RECRUITING | 351 | Apr 13, 2028 | ||||||
| Elecoglipron Small moleculeNCT07753993 | Chronic Kidney Disease | Phase 3 | RECRUITING | 7,000 | Oct 4, 2030 | ||||||
| Elecoglipron Small moleculeNCT07761117 | Heart Failure With Preserved Ejection Fraction (HFpEF) | Phase 3 | RECRUITING | 6,950 | Sep 3, 2029 | ||||||
| Datopotamab deruxtecan ADCNCT05687266 | NSCLC | Phase 3 | ACTIVE NOT_RECRUITING | 1,350 | Nov 1, 2027 | ||||||
| Dato-DXd ADCNCT06417814 | Metastatic Non-small Cell Lung Cancer | Phase 3 | ACTIVE NOT_RECRUITING | 768 | Sep 27, 2028 | ||||||
| Datopotamab deruxtecan ADCNCT05215340 | Metastatic Non Small Cell Lung Cancer | Phase 3 | RECRUITING | 740 | Apr 30, 2028 | ||||||
| Dato-DXd ADCNCT07720284 | High-risk Muscle Invasive Urothelial Carcinoma | Phase 3 | RECRUITING | 915 | Nov 23, 2032 | ||||||
| Datopotamab deruxtecan ADCNCT06564844 | Non-small Cell Lung Cancer | Phase 3 | ACTIVE NOT_RECRUITING | 1,100 | Mar 31, 2027 | ||||||
| Datopotamab deruxtecan ADCMarketedNCT07069595 | Breast Cancer | Phase 2 | RECRUITING | 78 | Nov 1, 2032 | ||||||
| Datopotamab deruxtecan ADCNCT05489211 | Endometrial Cancer | Phase 2 | RECRUITING | 454 | Oct 1, 2027 | ||||||
| Dato-DXd ADCNCT07129993 | Urothelial Cancer | Phase 2 | RECRUITING | 630 | Jan 22, 2030 | ||||||
| Datopotamab deruxtecan ADCNCT05460273 | Carcinoma, Non-Small-Cell Lung | Phase 1 | ACTIVE NOT_RECRUITING | 119 | Jun 30, 2027 | ||||||
| Datopotamab deruxtecan ADCNCT04612751 | Advanced or Metastatic NSCLC | Phase 1 | ACTIVE NOT_RECRUITING | 155 | May 4, 2027 | ||||||
| AZD0780 Small moleculeNCT07000136 | Heterozygous Familial Hypercholesterolaemia | Phase 3 | ACTIVE NOT_RECRUITING | 473 | Jan 4, 2027 | ||||||
| Laroprovstat Small moleculeNCT07619118 | Hypercholesterolaemia | Phase 3 | RECRUITING | 800 | May 28, 2027 | ||||||
| AZD0780 Small moleculeNCT07000123 | Cardiovascular Disease | Phase 3 | ACTIVE NOT_RECRUITING | 18,211 | Jan 11, 2027 | ||||||
| Rilvegostomig Monoclonal antibodyNCT06868277 | Carcinoma, Non-Small Cell Lung | Phase 3 | RECRUITING | 830 | Dec 2, 2030 | ||||||
| Volrustomig Monoclonal antibodyNCT06943833 | Locally Advanced Cervical Cancer | Phase 3 | ACTIVE NOT_RECRUITING | 837 | Mar 13, 2029 | ||||||
| Volrustomig Small moleculeNCT05984277 | Metastatic Non-small Cell Lung Cancer | Phase 3 | ACTIVE NOT_RECRUITING | 895 | Nov 12, 2027 | ||||||
| Rilvegostomig Small moleculeNCT06627647 | Non-squamous Non-small Cell Lung Cancer | Phase 3 | RECRUITING | 1,160 | Nov 18, 2030 | ||||||
| Rilvegostomig Small moleculeNCT07098338 | Non-Small Cell Lung Cancer | Phase 3 | RECRUITING | 1,438 | Apr 6, 2029 | ||||||
| Rilvegostomig Small moleculeNCT06764875 | HER2-positive Gastric Cancer | Phase 3 | RECRUITING | 840 | Dec 9, 2030 | ||||||
| Saruparib Small moleculeNCT06380751 | Advanced Breast Cancer | Phase 3 | RECRUITING | 788 | Dec 30, 2031 |
Clinical Trial Results
Readouts, endpoints and source filings for every AZN program
| Drug Name | Indication | Phase | Date | Trial Results Summary | Title | Source |
|---|---|---|---|---|---|---|
| Sone-Ve | CLDN18.2-positive gastric cancer | Phase 3 | 2026-10-19 | statistically significant and clinically meaningful overall survival (OS) benefitRead More | AstraZeneca to present overall survival data from four pivotal Phase III trials in Presidential Symposia at ESMO 2026 featuring Sone-Ve, IMFINZI® (durvalumab), TAGRISSO® (osimertinib) and savolitinibRead More |
Inside Trades
| Insider | Side | Shares | Price | Value | Date |
|---|---|---|---|---|---|
| Sharma ManiOfficer (See Remarks) | Buy | 20.233 19,287.699 held | $160.57 | 08/08/2026 |
Hedge Fund 13F Activity
Hedge Funds invested in AZN
| Fund | % of Portfolio | Current MV | Shares Owned | Activity |
|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 3.2 % (23.1 %) | 171.08 M | 915.70 K | 36.63% ( 245.50 K) |
AZN Institutional Ownership Trends
AZN Short Interest
Shares sold short, counted twice a month.
Options Data
Option Volume
Option Chain Statistics
| Expiry | Call Vol | Put Vol | Vol P/C | Call OI | Put OI | OI P/C | IV Call | IV Call OI-Wtd | IV Call Vol-Wtd | IV Put | IV Put OI-Wtd | IV Put Vol-Wtd |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026-11-20 | ||||||||||||
Real-Time Option Chain
| Calls | Strike | Puts | ||||
|---|---|---|---|---|---|---|
| Last | Vol | OI | Last | Vol | OI | |
| No data available | ||||||
Calls vs Puts by Expiry
Competitive positioning
How AZN ranks across every disease it competes in
AZN News
AstraZeneca to present overall survival data from four pivotal Phase III trials in Presidential Symposia at ESMO 2026 featuring Sone-Ve, IMFINZI® (durvalumab), TAGRISSO® (osimertinib) and savolitinib
AstraZeneca will present pivotal Phase III trial data at the ESMO Congress 2026, showcasing promising results for several cancer treatments. Key highlights include the CLARITY-Gastric01 trial of Sone-Ve, which shows significant overall survival benefits for gastric cancer patients, and the SAFFRON trial, demonstrating the efficacy of TAGRISSO combined with savolitinib for lung cancer. The findings suggest a transformative potential for combination therapies in improving patient outcomes across various cancer types.
Read more →insitro Announces a Strategic Collaboration with AstraZeneca for AI-enabled Discovery of Novel Therapeutics for MASH and Cardiomyopathies
insitro has entered a strategic collaboration with AstraZeneca to leverage its AI platform for discovering new therapeutics targeting metabolic dysfunction-associated steatohepatitis (MASH) and cardiomyopathies. The agreement includes an upfront payment of $40 million and potential milestones totaling approximately $1.46 billion. AstraZeneca will oversee clinical development and commercialization, aiming to address the complexities of these underdiagnosed diseases.
Read more →AstraZeneca opens new global strategic R&D center in Kendall Square, Cambridge, Massachusetts
AstraZeneca has inaugurated a new global strategic R&D center in Kendall Square, Cambridge, Massachusetts. This facility strengthens the company's existing presence in the area and aims to foster innovation by placing scientists in a leading life sciences ecosystem. The center is expected to enhance collaboration in genomic medicine and other research areas.
Read more →Daiichi Sankyo and AstraZeneca Enter into Clinical Trial Collaboration with Summit Therapeutics to Evaluate Datroway® in Combination with Ivonescimab Across Multiple Tumor Types
Daiichi Sankyo and AstraZeneca have formed a clinical trial collaboration with Summit Therapeutics to assess the efficacy of Datroway® in combination with ivonescimab across various tumor types, including lung and breast cancers. The collaboration will commence with a phase 3 trial focusing on first-line treatment for triple negative breast cancer. This partnership aims to enhance treatment options for patients with these cancers.
Read more →Eccogene Receives $50 Million Milestone Payment from AstraZeneca Following Initiation of Global Phase 3 Program for Elecoglipron (AZD5004/ECC5004)
Eccogene has received a $50 million milestone payment from AstraZeneca following the initiation of a Global Phase 3 program for Elecoglipron (AZD5004/ECC5004). This payment marks a significant step in the development of the drug, showcasing the partnership's progress. The Phase 3 program is crucial for the drug's potential approval and market entry.
Read more →Polaris Rx Named Exclusive U.S. Distributor of AstraZeneca's FluMist® Home Service for Second Consecutive Year
Polaris Rx has been named the exclusive U.S. distributor for AstraZeneca's FluMist Home service for the 2026-2027 flu season, marking the second consecutive year of this partnership. This service allows individuals to conveniently order the flu vaccine online and have it delivered directly to their homes. The collaboration aims to improve access to flu vaccinations.
Read more →Susan G. Komen® and AstraZeneca Partnership to Make Patient Navigation Available to All
Susan G. Komen has partnered with AstraZeneca to enhance patient navigation in breast cancer care. This initiative aims to integrate patient navigation into the national healthcare system, addressing barriers and improving access to timely treatments. The collaboration seeks to reduce patient stress and enhance adherence to cancer care plans across the nation.
Read more →AstraZeneca completes global license agreement for oral EGFR inhibitor ZEGFROVY® (sunvozertinib) for lung cancer
AstraZeneca has finalized a global license agreement with Dizal Pharmaceutical for ZEGFROVY (sunvozertinib), an oral EGFR inhibitor for lung cancer. This agreement grants AstraZeneca worldwide rights to develop and commercialize the drug, which is already approved in the US and China for second-line treatment in adults.
Read more →AstraZeneca results: H1 and Q2 2026
AstraZeneca reported strong financial results for H1 2026, with total revenue increasing by 9% compared to the previous year. Product sales reached $28.9 billion, reflecting an 8% growth. The company's core EPS also showed a positive trend, rising by 12%. However, collaboration revenue experienced a decline of 6%. Overall, the results indicate a solid performance despite some challenges.
Read more →Dizal Announces Global Exclusive License Agreement with AstraZeneca for Zegfrovy
Dizal has entered a global exclusive license agreement with AstraZeneca for Zegfrovy, an EGFR inhibitor for lung cancer. The deal includes a $600M upfront payment and potential milestone payments of up to $900M. Zegfrovy is already approved in China and the US for treating advanced NSCLC with specific mutations. AstraZeneca aims to leverage its oncology expertise to expand Zegfrovy's reach.
Read more →Helix Announces Multi-Year Agreement with AstraZeneca to Support Genomic Research for Drug Discovery and Development
Helix has entered a multi-year agreement with AstraZeneca to provide access to its GenoSphere cohorts, which include extensive genomic and clinical data. This collaboration aims to enhance drug discovery and development by leveraging integrated clinico-genomic data. The partnership is expected to accelerate biomedical research and improve the development of targeted therapies.
Read more →Abbisko Therapeutics and AstraZeneca Enter a Strategic Collaboration to Conduct the Clinical Trial of Lumipodlin (ABSK043), a First-in-Class Oral PD-L1 Inhibitor, in Combination with TAGRISSO® for NSCLC
Abbisko Therapeutics has partnered with AstraZeneca to conduct a Phase I/II clinical trial for lumipodlin (ABSK043), an oral PD-L1 inhibitor, in combination with TAGRISSO® for treating non-small cell lung cancer (NSCLC). The trial aims to evaluate the safety and efficacy of this novel therapy for patients with EGFR mutations and high PD-L1 expression. The IND application for the study was recently approved by the National Medical Products Administration.
Read more →AstraZeneca and YMCA of the USA Announce Landmark Partnership Aimed to Address Gaps in Cancer Care
AstraZeneca has formed a partnership with YMCA of the USA to tackle disparities in cancer care. This collaboration aims to enhance accessibility and improve health outcomes for communities. The initiative is expected to address critical gaps in healthcare services related to cancer treatment and support.
Read more →Lung Cancer Research Foundation and AstraZeneca Announce Open Call for Research Proposals with Focus on Small Cell Lung Cancer
The Lung Cancer Research Foundation and AstraZeneca have announced two research awards aimed at improving treatment outcomes for small cell lung cancer (SCLC). The awards, totaling $750,000, will support innovative strategies and patient advocacy efforts. Submissions for research proposals are open until July 15, 2026, with the goal of advancing understanding and treatment of this challenging cancer.
Read more →Datroway® Approved in the U.S. as First TROP2 Directed Antibody Drug Conjugate for First-Line Treatment of Patients with Metastatic Triple Negative Breast Cancer Who Are Not PD-1/PD-L1 Inhibitor Candidates
Datroway® has received U.S. approval as the first TROP2 directed antibody drug conjugate. It is intended for first-line treatment of patients with metastatic triple negative breast cancer who are not eligible for PD-1/PD-L1 inhibitors. This approval marks a significant advancement in treatment options for this patient population.
Read more →AstraZeneca Collaborates with Roche Diagnostics Asia Pacific to Help Accelerate Sustainable Ecosystem for Advanced Pathology in Breast and Lung Cancer
AstraZeneca and Roche Diagnostics Asia Pacific have entered a three-year Memorandum of Understanding to enhance digital pathology capabilities across nine Asian markets. This collaboration aims to improve biomarker testing for breast and lung cancer through AI-powered solutions and educational initiatives. The partnership addresses significant gaps in diagnostic processes and aims to standardize and improve cancer care.
Read more →TRUQAP® (capivasertib) recommended by FDA Advisory Committee for PTEN-deficient metastatic hormone-sensitive prostate cancer
The FDA's Oncologic Drugs Advisory Committee has recommended AstraZeneca's TRUQAP (capivasertib) in combination with abiraterone and ADT for PTEN-deficient metastatic hormone-sensitive prostate cancer. This recommendation is based on favorable results from the CAPItello-281 Phase III trial, which demonstrated a significant reduction in disease progression. The treatment addresses a critical need for patients with limited options and is the first targeted therapy for this cancer subtype.
Read more →Koselugo approved in Canada for plexiform neurofibromas in adults with neurofibromatosis type 1
Koselugo (selumetinib) has been approved in Canada for adults with neurofibromatosis type 1 (NF1) suffering from symptomatic, inoperable plexiform neurofibromas. This approval follows positive results from the KOMET Phase III trial, which showed a 20% objective response rate in tumor size reduction. Experts highlight the significance of this treatment option for patients who previously had limited therapeutic choices.
Read more →ENHERTU® Granted Priority Review in the U.S. as Post-Neoadjuvant Treatment for Patients with HER2 Positive Early Breast Cancer
AstraZeneca and Daiichi Sankyo's ENHERTU has received Priority Review from the FDA for treating HER2 positive early breast cancer patients with residual disease after neoadjuvant therapy. The decision follows promising results from the DESTINY-Breast05 trial, which demonstrated a significant reduction in disease recurrence. The FDA's target action date for this application is July 7, 2026.
Read more →SECURITIES AND EXCHANGE COMMISSION
AstraZeneca PLC has filed a report with the SEC for February 2026, according to the requirements set forth by the Securities Exchange Act of 1934. The filing includes details about the registrant’s annual financial report and compliance with various regulatory requirements. This follows standard practice for foreign issuers under SEC regulations.
Read more →