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ARGX-109

Phase 1

Healthy Volunteer | Monoclonal antibody | Other |argenx SE|Last Updated: Sep 18, 2025

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment40

FDA Designations

No designations recorded

Clinical trial landscape

ARGX-109 · 1 trial · 1 indication

Phase 1 1
NCT06799416A Study to Assess the Safety of ARGX-109 in Healthy VolunteersHealthy Volunteer
COMPLETED40 Analytics
PHASE1COMPLETED
A Study to Assess the Safety of ARGX-109 in Healthy Volunteers
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Study Endpoints

Primary Endpoints

Incidence of AEs, SAEs and AEs leading to discontinuation
up to 16 weeks

AE: adverse event, SAE: serious adverse event

Secondary Endpoints

Cmax
up to 16 weeks
Total IL-6 serum concentrations
up to 16 weeks
Incidence of ADA against ARGX-109 in serum
up to 16 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ARGX-109EXPERIMENTALParticipants receiving the experimental drug
PlaceboPLACEBO_COMPARATORParticipants receiving placebo

Interventions

NameTypeDescription
ARGX-109BIOLOGICALadministrations of ARGX-109
PlaceboOTHERadministrations of placebo comparator
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * is aged 18 to 65 years, inclusive, when signing the ICF * has a body weight between 50 and 100 kg and a BMI between 18.5 and 30.0 kg/m2, inclusive Exclusion Criteria: * Has any current or past clinically meaningful medical or psychiatric condition that, in the investigator's...

Countries:Canada
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Frequently asked questions about ARGX-109

What is ARGX-109 used for?

ARGX-109 is an investigational monoclonal antibody being studied in healthy volunteers. It is currently in Phase 1 clinical development, with a completed trial assessing its safety in this population. The drug is not approved for any indication and remains under investigation.

Who makes ARGX-109?

ARGX-109 is being developed by argenx SE, a biopharmaceutical company traded on the stock exchange under the ticker ARGX. The company is conducting clinical trials to evaluate the safety of this investigational monoclonal antibody in healthy volunteers.

What phase is ARGX-109 in?

ARGX-109 is in Phase 1 clinical development. A Phase 1 trial has been completed, and the drug remains investigational. It has not been approved by regulatory authorities and is still undergoing clinical evaluation for safety in healthy volunteers.

What clinical trials is ARGX-109 in?

ARGX-109 has one completed clinical trial, identified as NCT06799416, titled "A Study to Assess the Safety of ARGX-109 in Healthy Volunteers." This Phase 1, randomized, double-blind, placebo-controlled study enrolled 40 participants in Canada and included healthy volunteers aged 18 years and older.

Is ARGX-109 FDA approved?

ARGX-109 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development. A completed trial has assessed its safety in healthy volunteers, but the drug has not received regulatory approval for any use.