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ARGX-109

Phase 1

Healthy Volunteer | Monoclonal antibody | Other |argenx SE|Last Updated: Sep 18, 2025

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment40
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06799416A Study to Assess the Safety of ARGX-109 in Healthy VolunteersPHASE1 COMPLETED 40Jan 14, 2025Aug 8, 2025Sep 18, 20251 Canada
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Study Endpoints
Primary Endpoints
Incidence of AEs, SAEs and AEs leading to discontinuation
up to 16 weeks

AE: adverse event, SAE: serious adverse event

Secondary Endpoints
Cmax
up to 16 weeks
Total IL-6 serum concentrations
up to 16 weeks
Incidence of ADA against ARGX-109 in serum
up to 16 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
ARGX-109EXPERIMENTALParticipants receiving the experimental drug
PlaceboPLACEBO_COMPARATORParticipants receiving placebo
Interventions
NameTypeDescription
ARGX-109BIOLOGICALadministrations of ARGX-109
PlaceboOTHERadministrations of placebo comparator
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * is aged 18 to 65 years, inclusive, when signing the ICF * has a body weight between 50 and 100 kg and a BMI between 18.5 and 30.0 kg/m2, inclusive Exclusion Criteria: * Has any current or past clinically meaningful medical or psychiatric condition that, in the investigator's...

Countries:Canada
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