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DA-020

Phase 1

Chemotherapy Induced Alopecia | Small molecule | Other |Applied Therapeutics, Inc.|Last Updated: Apr 13, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment60
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07397325Clinical Study of DA-020 for the Treatment of Chemotherapy Induced AlopeciaPHASE1 NOT YET_RECRUITING 60Apr 16, 2026Dec 7, 2026Apr 13, 20262 Brazil, Italy
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Study Endpoints
Primary Endpoints
Prevention of Hair Loss (Common Terminology Criteria for Adverse Events V5.0)
Week [0,12]

Amount of hair loss during chemotherapy treatment measured by the Common Terminology Criteria for Adverse Events (CTCAE) V5.0. The Common Terminology Criteria for Adverse Events is a common terminology developed by the National Cancer Institute to describe and grade adverse events related to cancer therapy.

Secondary Endpoints
Hair Re-Growth Post Treatment (Common Terminology Criteria for Adverse Events V5.0)
Week [12, 24]
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
DA-020ACTIVE_COMPARATORTopical DA-020 Solution
PlaceboPLACEBO_COMPARATORTopical Placebo Solution
DA-020 and Hyperforin (1.5%)ACTIVE_COMPARATORDA-020 and Hyperforin (1.5%)
Interventions
NameTypeDescription
DA-020DRUG7mL application of DA-020 (Topical Oxymetazoline)
PlaceboDRUGTopical placebo solution
DA-020 and HyperforinDRUG7mL application of DA-020 (Topical Oxymetazoline) and Hyperforin (1.5%)
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Eligibility Criteria
Age Range18 Years — 65 Years
SexFEMALE
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: * Diagnosed with stage I or stage II breast cancer * Scheduled but not begun, at least 4 cycles of taxane and/or anthracycline-based chemotherapy. * Ages 18-65 * Able to give informed consent Exclusion Criteria: * Resting blood pressure outside the range of 105-140/ 55-99 * Un...

Countries:BrazilItaly
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