Recent Updates
Recently added Catalysts

CS-002

Phase 1

Canities | Small molecule | Other |Applied Therapeutics, Inc.|Last Updated: Sep 10, 2025

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment100
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07166354Clinical Study of mTOR Inhibitor as a Treatment for Grey Hair (Canities)PHASE1 NOT YET_RECRUITING 100Oct 1, 2025Sep 15, 2027Sep 10, 2025 -
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Greying Severity Score
Week [0,24]

Greying Severity Score (GSS). Mild Greying score between 0-5, Moderate Greying score between 6-10 and Severe Greying score between 11-15

Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
CS-002EXPERIMENTALCS-002 Topical Treatment
PlaceboPLACEBO_COMPARATORPlacebo Topical Treatment
Interventions
NameTypeDescription
CS-002DRUGCS-002 Topical Treatment
Placebo Topical SolutionDRUGPlacebo Topical Solution
Unlock Study Design Details
Eligibility Criteria
Age Range30 Years — 65 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Age 30 to 65 * Diagnosed with Grey Hair (Canities) * Willing and able to apply the treatment as directed, comply with study * Otherwise healthy * Able to give informed consent Exclusion Criteria: * A medical history that may interfere with study objectives * Women who are pr...

Unlock Eligibility Criteria