Recent Updates
Recently added Catalysts

CCX282-B

Phase 2

Crohn Disease | Small molecule | Immunology |Amgen Inc.|Last Updated: Mar 6, 2025

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindUNCONTROLLEDBiomarker
Total Trials1
Total Enrollment70
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00102921Safety and Activity Study of an Oral Medication to Treat Moderate to Severe Crohn's DiseasePHASE2 COMPLETED 70Aug 1, 2004Dec 1, 2005Mar 6, 202514 United States
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Crohn's Disease Activity Index score
Safety (Adverse Events, tolerability)
Secondary Endpoints
Inflammatory Bowel Disease Questionnaire
C-reactive protein
Endoscopic appearance and biopsy of colon and terminal ileum
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Interventions
NameTypeDescription
CCX282-BDRUG -
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites14

Inclusion Criteria: * Diagnosis of moderate to severe Crohn's Disease in small intestine; disease must be active at the time of study entry * Use of adequate and approved methods of birth control throughout the study period * Willing and able to sign an informed consent Exclusion Criteria: * Preg...

Countries:United States
Unlock Eligibility Criteria