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Zoetis Reports Fourth Quarter and Full Year 2025 Results

Key Takeaway: Zoetis Inc. reported strong financial results for Q4 and full year 2025, with revenues of $2.4 billion and $9.5 billion, respectively. The company highlighted growth in adjusted net income and successful regulatory approvals for new osteoarthritis pain products. Looking ahead, Zoetis provided guidance for 2026 and emphasized its commitment to innovation and market expansion.
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Market Sentiment Analysis

POSITIVE FACTORS

  • Revenue for Q4 2025 increased by 3% compared to Q4 2024.
  • Zoetis achieved key milestones with regulatory approvals for new OA pain products.
  • The company reported solid financial results and growth in adjusted net income.
  • Zoetis is on track to receive significant approvals annually for its pipeline candidates.

Full Press Release Details

PARSIPPANY, N.J.--(BUSINESS WIRE)--Zoetis Inc.(NYSE: ZTS), the world's leading animal health company, today reported its financial results for the fourth quarter and full year 2025 and provided full year guidance for 2026.
The company reported revenue of $2.4 billion for the fourth quarter of 2025, an increase of 3% compared with the fourth quarter of 2024. On an organic operational1basis, revenue for the fourth quarter of 2025 increased 4% compared with the fourth quarter of 2024. Net income for the fourth quarter of 2025 was $603 million, or $1.37 per diluted share, an increase of 4% and 6%, respectively, on a reported basis.
Adjusted net income2for the fourth quarter of 2025 was $648 million, or $1.48 per diluted share, an increase of 3% and 6%, respectively, on a reported basis, and an increase of 4% and 7%, respectively, on an organic operational basis. Adjusted net income for the fourth quarter of 2025 excludes the net impact of $45 million for purchase accounting adjustments, acquisition and divestiture-related costs, and certain significant items.
For full year 2025, the company reported revenue of $9.5 billion, an increase of 2% compared with full year 2024. On an organic operational basis, revenue for full year 2025 increased 6%. Net income for full year 2025 was $2.7 billion, or $6.02 per diluted share, an increase of 8% and 10%, respectively, on a reported basis.
Adjusted net incomefor full year 2025 was $2.8 billion, or $6.41 per diluted share, an increase of 6% and 8%, respectively, on a reported basis, and 7% and 10%, respectively, on an organic operational basis. Adjusted net income for full year 2025 excludes the net impact of $174 million for purchase accounting adjustments, acquisition and divestiture-related costs, and certain significant items.
"Zoetis delivered solid results in 2025, demonstrating the strength and resilience of our portfolio across species, geographies, and channels. Leadership across key brands and categories drove continued growth, even as we navigated a dynamic operating environment,” said Kristin Peck, Chief Executive Officer of Zoetis. "Advancing our innovative pipeline is central to our strategy, and we achieved key milestones in 2025, including the first regulatory approvals for long-acting OA pain products Lenivia and Portela. We continue to compete from a position of strength, anchored in differentiated science, trusted brands, global reach, and enduring customer relationships. Our disciplined execution positions us well as we move into 2026 and lay the groundwork for the next phase of our innovation cycle, supporting sustainable growth and long-term value creation.”
QUARTERLY HIGHLIGHTSZoetis organizes and manages its commercial operations across two regional segments: United States (U.S.) and International. Within these segments, the company delivers a diverse portfolio of products for companion animals and livestock, tailored to local trends and customer needs. For the fourth quarter of 2025:
EXPECTED FISCAL YEAR ALIGNMENTWhen Zoetis adopts the Expected Fiscal Year Alignment, the company will retroactively apply the new accounting principle to prior financial statement periods, which will allow for a comparison of the financial results to historical operations. The operational changes in connection with the Expected Fiscal Year Alignment to date also included a shift implemented in early 2026 to the timing of annual price increases in certain International Subsidiaries so that the price increase and anticipated customer buying preceding the price increase would occur in the same calendar year. In addition, processing of certain customer orders from December 2025 was delayed to calendar year 2026.
INVESTMENTS IN GROWTHZoetis continued to advance care for animals across the globe in 2025 with approximately 185 geographic expansion and lifecycle and new product innovations.
Continued Expansion of OA Pain FranchiseAmong those, most notable were the company’s approvals for its long-acting monoclonal antibodies for osteoarthritis pain in dogs and cats, reflecting the continued expansion of Zoetis’ OA pain franchise.
In the fourth quarter, Zoetis received approval in Canada and the EU forLenivia®, the first long-acting monoclonal antibody to manage OA pain in dogs for up to three months with one injection, marking a significant scientific milestone. Lenivia addresses the significant unmet needs of this market as nearly 40% of dogs of any age or size may be affected by OA pain4, 5and chronic pain can negatively impact dogs’ movement, sleep, behavior and social relationships6.
Portela®, the first monoclonal antibody therapy with a three-month dosing interval approved for the alleviation of pain associated with OA in cats, was approved in Canada and the EU. This important milestone addresses unmet needs in the market, as up to 40% of all cats have clinical signs of OA7, 8. Zoetis expects to launch Lenivia and Portela in Canada and the EU this year.
Additionally, the company received lifecycle innovation and geographic expansion approvals for key franchise products including Simparica Trio, Apoquel and Cytopoint. The company also received conditional licenses to combat emerging infectious diseases, including H5N2 avian influenza vaccines for use in chickens and lactating dairy cattle, and conditional approval for Dectomax-CA1 Injectable to prevent and treat New World screwworm.
Zoetis remains on track to receive a significant approval in a major market every year for the next several years, with 12 of its pipeline candidates having blockbuster9potential.
Continued Enhancement of Diagnostic CapabilitiesIn November, Zoetis acquired Veterinary Pathology Group (VPG), a leading veterinary diagnostic laboratory group with multiple locations across the UK and Ireland. The acquisition further expands the company's comprehensive diagnostics portfolio and reinforces its commitment to advancing animal health through innovative, high-quality diagnostic solutions. VPG’s extensive suite of multi-specialty diagnostic services and experienced team complement Zoetis’ existing capabilities, enabling enhanced support for veterinarians with faster, more accurate diagnostic insights that improve clinical outcomes for animals.
FINANCIAL GUIDANCEZoetis is providing full year 2026 guidance as follows:
This guidance reflects foreign exchange rates as of January 20, 2026. Additional details on guidance are included in the financial tables and will be discussed on the company's conference call.
WEBCAST & CONFERENCE CALL DETAILSZoetis will host a webcast and conference call today at 8:30 a.m. ET to review fourth quarter and full year 2025 results, discuss financial guidance and respond to questions from financial analysts. The live webcast and corresponding slides can be accessed by visiting the Zoetis website athttps://investor.zoetis.com/events-presentations. A replay of the webcast will be available following the event.
About ZoetisZoetis is the world’s leading animal health company, driven by a singular purpose: to nurture our world and humankind by advancing care for animals. With a legacy of nearly 75 years, Zoetis continues to pioneer ways to predict, prevent, detect, and treat animal illness, supporting veterinarians, livestock producers, and pet owners in over 100 countries. We integrate deep scientific expertise, data-driven R&D, advanced manufacturing, and commercial excellence to deliver meaningful innovation across medicines, vaccines, diagnostics, biopharmaceuticals, and digital solutions. Guided by our vision to be the most trusted and valued animal health company, Zoetis is committed to setting new standards for the future of animal care through innovation, customer obsession, and purpose-driven colleagues. To learn more, visitZoetis.com.
1Organic operational results (a non-GAAP financial measure) is defined as results excluding the impact of foreign exchange and certain acquisitions and divestitures.
2Adjusted net income and its components and adjusted diluted earnings per share (non-GAAP financial measures) are defined as reported net income and reported diluted earnings per share, excluding purchase accounting adjustments, acquisition and divestiture-related costs and certain significant items.
3Operational results (a non-GAAP financial measure) is defined as results excluding the impact of foreign exchange..
4Wright A, Amodie DM, Cernicchiaro N, et al. Identification of canine osteoarthritis using an owner-reported questionnaire and treatment monitoring using functional mobility tests. J Small Anim Pract. 2022;63(8):609-618.
5Enomoto M, de Castro N, Hash J, et al. Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogs. Sci Rep. 2024;14(1):2827.
6Lascelles BDX, Brown DC, Conzemius MG, Gill M, Oshinsky ML, Sharkey ML. Measurement of chronic pain in companion animals: discussions from the Pain in Animals Workshop (PAW) 2017. Vet J. 2019;250:71-78.
7Enomoto M, Mantyh PW, Murrell J, Innes JF, Lascelles BDX. Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats. Vet Rec. 2019;184(1):23.
8L.I. Slingerland, H.A.W. Hazewinkel, B.P. Meij, Ph. Picavet, G. Voorhout, Cross-sectional study of the prevalence and clinical features of osteoarthritis in 100 cats. The Veterinary Journal, Volume 187, Issue 3, 2011, Pages 304-309.
9A blockbuster has sales of at least $100 million.
DISCLOSURE NOTICESForward-Looking Statements: This press release contains forward-looking statements, which reflect the current views of Zoetis with respect to: business plans or prospects, future operating or financial performance, future guidance, future operating models; R&D costs; timing and likelihood of success; expectations regarding products, product approvals or products under development and expected timing of product launches; expectations regarding competing products; expectations regarding financial impact of divestitures; disruptions in our global supply chain; expectations regarding the performance of acquired companies and our ability to integrate new businesses; expectations regarding the financial impact of acquisitions; future use of cash, dividend payments and share repurchases; foreign exchange rates, tax rates, tariffs, changes in tax regimes and laws and any changes thereto; impacts of the timing and pricing of sales in the International segment; possible impacts of the Expected Fiscal Year Alignment;and other future events. These statements are not guarantees of future performance or actions. Forward-looking statements are subject to risks and uncertainties. If one or more of these risks or uncertainties materialize, or if management's underlying assumptions prove to be incorrect, actual results may differ materially from those contemplated by a forward-looking statement. Forward-looking statements speak only as of the date on which they are made. Zoetis expressly disclaims any obligation to update or revise any forward-looking statement, whether as a result of new information, future events or otherwise. A further list and description of risks, uncertainties and other matters can be found in our most recent Annual Report on Form 10-K, including in the sections thereof captioned “Forward-Looking Statements and Factors That May Affect Future Results” and “Item 1A. Risk Factors,” in our Quarterly Reports on Form 10-Q and in our Current Reports on Form 8-K. These filings and subsequent filings are available online atwww.sec.gov,www.zoetis.com, or on request from Zoetis.
Use of Non-GAAP Financial Measures: We use non-GAAP financial measures, such as adjusted net income, adjusted diluted earnings per share, operational results (which exclude the impact of foreign exchange) and organic operational results (which exclude the impact of foreign exchange and certain acquisitions and divestitures), to assess and analyze our results and trends and to make financial and operational decisions. We believe these non-GAAP financial measures are also useful to investors because they provide greater transparency regarding our operating performance. The non-GAAP financial measures included in this press release should not be considered alternatives to measurements required by GAAP, such as net income, operating income, and earnings per share, and should not be considered measures of liquidity. These non-GAAP financial measures are unlikely to be comparable with non-GAAP information provided by other companies. Reconciliations of non-GAAP financial measures and the most directly comparable GAAP financial measures are included in the tables accompanying this press release and are posted on our website atwww.zoetis.com.
Internet Posting of Information: We routinely post information that may be important to investors on the 'Investor Relations' section of our website atwww.zoetis.com, as well as onLinkedIn,Facebook,X (formerly Twitter)and YouTube. We encourage investors and potential investors to consult our website regularly and to follow us on social media for company news and information.
ZTS-CORZTS-IRZTS-FIN
ZOETIS INC.CONDENSED CONSOLIDATED STATEMENTS OF INCOME(a)(UNAUDITED)(millions of dollars, except per share data)
Three Months EndedDecember 31, % Change Twelve Months EndedDecember 31, % Change
2025 2024 2025 2024
Revenue $ 2,387 $ 2,317 3 $ 9,467 $ 9,256 2
Costs and expenses:
Cost of sales 712 707 1 2,666 2,719 (2 )
Selling, general and administrative expenses 619 625 (1 ) 2,378 2,318 3
Research and development expenses 199 186 7 698 686 2
Amortization of intangible assets 31 34 (9 ) 128 141 (9 )
Restructuring charges and certain acquisition and divestiture-related costs 17 2 * 51 53 (4 )
Interest expense 57 51 12 222 225 (1 )
Other (income)/deductions–net (9 ) (20 ) (55 ) (36 ) (19 ) 89
Income before provision for taxes on income 761 732 4 3,360 3,133 7
Provision for taxes on income 158 151 5 687 637 8
Net income before allocation to noncontrolling interests 603 581 4 2,673 2,496 7
Less: Net income/(loss) attributable to noncontrolling interests * 10 *
Net income attributable to Zoetis $ 603 $ 581 4 $ 2,673 $ 2,486 8
Earnings per share—basic $ 1.38 $ 1.29 7 $ 6.03 $ 5.47 10
Earnings per share—diluted $ 1.37 $ 1.29 6 $ 6.02 $ 5.47 10
Weighted-average shares used to calculate earnings per share
Basic 438.2 450.5 443.4 454.2
Diluted 438.6 451.1 443.8 454.8
(a) The Condensed Consolidated Statements of Income present the three and twelve months ended December 31, 2025 and 2024. Subsidiaries operating outside the U.S. are included for the three and twelve months ended November 30, 2025 and 2024.
* Calculation not meaningful.
ZOETIS INC.RECONCILIATION OF GAAP REPORTED TO NON-GAAP ADJUSTED INFORMATIONCERTAIN LINE ITEMS(UNAUDITED)(millions of dollars, except per share data)
Three Months Ended December 31, 2025
GAAPReported(a) PurchaseAccountingAdjustments AcquisitionandDivestiture-RelatedCosts(1) CertainSignificantItems(2) Non-GAAPAdjusted(b)
Cost of sales $ 712 $ (1 ) $ $ (3 ) $ 708
Gross profit 1,675 1 3 1,679
Selling, general and administrative expenses 619 (3 ) (1 ) 615
Amortization of intangible assets 31 (27 ) 4
Restructuring charges and certain acquisition and divestiture-related costs 17 (1 ) (16 )
Other (income)/deductions–net (9 ) (2 ) (11 )
Income before provision for taxes on income 761 31 1 22 815
Provision for taxes on income 158 7 2 167
Net income attributable to Zoetis 603 24 1 20 648
Earnings per common share attributable to Zoetis–diluted 1.37 0.06 0.05 1.48
Three Months Ended December 31, 2024
GAAPReported(a) PurchaseAccountingAdjustments AcquisitionandDivestiture-RelatedCosts(1) CertainSignificantItems(2) Non-GAAPAdjusted(b)
Cost of sales $ 707 $ (1 ) $ $ $ 706
Gross profit 1,610 1 1,611
Selling, general and administrative expenses 625 (2 ) (4 ) 619
Amortization of intangible assets 34 (30 ) 4
Restructuring charges and certain acquisition and divestiture-related costs 2 (6 ) 4
Other (income)/deductions–net (20 ) (2 ) (22 )
Income before provision for taxes on income 732 33 6 2 773
Provision for taxes on income 151 7 1 (18 ) 141
Net income attributable to Zoetis 581 26 5 20 632
Earnings per common share attributable to Zoetis–diluted 1.29 0.06 0.01 0.04 1.40
(a) The Condensed Consolidated Statements of Income present the three months ended December 31, 2025 and 2024. Subsidiaries operating outside the U.S. are included for the three months ended November 30, 2025 and 2024.
(b) Non-GAAP adjusted net income and its components and non-GAAP adjusted diluted EPS are not, and should not be viewed as, substitutes for U.S. GAAP net income and its components and diluted EPS. Despite the importance of these measures to management in goal setting and performance measurement, non-GAAP adjusted net income and its components and non-GAAP adjusted diluted EPS are non-GAAP financial measures that have no standardized meaning prescribed by U.S. GAAP and, therefore, have limits in their usefulness to investors. Because of the non-standardized definitions, non-GAAP adjusted net income and its components and non-GAAP adjusted diluted EPS (unlike U.S. GAAP net income and its components and diluted EPS) may not be comparable to the calculation of similar measures of other companies. Non-GAAP adjusted net income and its components, and non-GAAP adjusted diluted EPS are presented solely to permit investors to more fully understand how management assesses performance.
See Notes to Reconciliation of GAAP Reported to Non-GAAP Adjusted Information for notes (1) and (2).
ZOETIS INC.RECONCILIATION OF GAAP REPORTED TO NON-GAAP ADJUSTED INFORMATIONCERTAIN LINE ITEMS(UNAUDITED)(millions of dollars, except per share data)
Twelve Months Ended December 31, 2025
GAAPReported(a) PurchaseAccountingAdjustments AcquisitionandDivestiture-RelatedCosts(1) CertainSignificantItems(2) Non-GAAPAdjusted(b)
Cost of sales $ 2,666 $ (4 ) $ $ (5 ) $ 2,657
Gross profit 6,801 4 5 6,810
Selling, general and administrative expenses 2,378 (11 ) (23 ) 2,344
Research and development expenses 698 (2 ) 696
Amortization of intangible assets 128 (111 ) 17
Restructuring charges and certain acquisition and divestiture-related costs 51 (2 ) (49 )
Other (income)/deductions–net (36 ) (5 ) (41 )
Income before provision for taxes on income 3,360 128 2 82 3,572
Provision for taxes on income 687 29 9 725
Net income attributable to Zoetis 2,673 99 2 73 2,847
Earnings per common share attributable to Zoetis–diluted 6.02 0.22 0.17 6.41
Twelve Months Ended December 31, 2024
GAAPReported(a) PurchaseAccountingAdjustments AcquisitionandDivestiture-RelatedCosts(1) CertainSignificantItems(2) Non-GAAPAdjusted(b)
Cost of sales $ 2,719 $ (4 ) $ $ (1 ) $ 2,714
Gross profit 6,537 4 1 6,542
Selling, general and administrative expenses 2,318 (11 ) (6 ) 2,301
Research and development expenses 686 (2 ) 684
Amortization of intangible assets 141 (123 ) 18
Restructuring charges and certain acquisition and divestiture-related costs 53 (18 ) (35 )
Other (income)/deductions–net (19 ) (37 ) (56 )
Income before provision for taxes on income 3,133 140 18 79 3,370
Provision for taxes on income 637 31 4 (5 ) 667
Net income attributable to Zoetis 2,486 109 14 84 2,693
Earnings per common share attributable to Zoetis–diluted 5.47 0.24 0.03 0.18 5.92
(a) The Condensed Consolidated Statements of Income present the twelve months ended December 31, 2025 and 2024. Subsidiaries operating outside the U.S. are included for the twelve months ended November 30, 2025 and 2024.
(b) Non-GAAP adjusted net income and its components and non-GAAP adjusted diluted EPS are not, and should not be viewed as, substitutes for U.S. GAAP net income and its components and diluted EPS. Despite the importance of these measures to management in goal setting and performance measurement, non-GAAP adjusted net income and its components and non-GAAP adjusted diluted EPS are non-GAAP financial measures that have no standardized meaning prescribed by U.S. GAAP and, therefore, have limits in their usefulness to investors. Because of the non-standardized definitions, non-GAAP adjusted net income and its components and non-GAAP adjusted diluted EPS (unlike U.S. GAAP net income and its components and diluted EPS) may not be comparable to the calculation of similar measures of other companies. Non-GAAP adjusted net income and its components, and non-GAAP adjusted diluted EPS are presented solely to permit investors to more fully understand how management assesses performance.
See Notes to Reconciliation of GAAP Reported to Non-GAAP Adjusted Information for notes (1) and (2).
ZOETIS INC.NOTES TO RECONCILIATION OF GAAP REPORTED TO NON-GAAP ADJUSTED INFORMATIONCERTAIN LINE ITEMS(UNAUDITED)(millions of dollars)
(1)Acquisition and divestiture-related costsinclude the following:
Three Months EndedDecember 31, Twelve Months EndedDecember 31,
2025 2024 2025 2024
Acquisition-related costs $ 1 $ $ 2 $ 1
Divestiture-related costs(a) 5 16
Restructuring charges(b) 1 1
Total acquisition and divestiture-related costs—pre-tax 1 6 2 18
Income taxes(c) 1 4
Total acquisition and divestiture-related costs—net of tax $ 1 $ 5 $ 2 $ 14
(a) Divestiture-related costs related to the sale of our medicated feed additive product portfolio, certain water soluble products and related assets, included inRestructuring charges and certain acquisition and divestiture-related costs.
(b) Restructuring charges represent employee termination costs directly related to acquisitions and divestitures, included inRestructuring charges and certain acquisition and divestiture-related costs.
(c) Included inProvision for taxes on income. Income taxes include the tax effect of the associated pre-tax amounts, calculated by determining the jurisdictional location of the pre-tax amounts and applying that jurisdiction's applicable tax rate.
(2)Certain significant itemsinclude the following:
Three Months EndedDecember 31, Twelve Months EndedDecember 31,
2025 2024 2025 2024
Other restructuring charges and cost-reduction/productivity initiatives(a) $ 16 $ (4 ) $ 27 $ 35
Business process transformation costs(b) 3 29
Certain asset impairment charges(c) 27 11
Net loss on sale of business(d) 3 3 25
Other 3 3 (4 ) 8
Total certain significant items—pre-tax 22 2 82 79
Income taxes(e) 2 (18 ) 9 (5 )
Total certain significant items—net of tax $ 20 $ 20 $ 73 $ 84
(a) For the three and twelve months ended December 31, 2025, primarily consisted of employee termination costs related to organizational structure refinements, included inRestructuring charges and certain acquisition and divestiture-related costs. For the twelve months ended December 31, 2025, charges also include costs related to a transition from internal to external innovation and manufacturing of certain products and the closure of a related site.
For the twelve months ended December 31, 2024, primarily consisted of employee termination costs related to organizational structure refinements, partially offset by a reversal of certain employee termination costs as a result of a change in strategy from our 2015 operational efficiency initiative, included inRestructuring charges and certain acquisition and divestiture-related costs.
(b) Represents costs related to our multi-year business process transformation program, which includes the implementation of a new enterprise resource planning (ERP) system, related digital technology solutions and other related costs, included inSelling, general and administrative expensesandCost of sales. This comprehensive program is a major global and cross-functional company-wide effort, of which the Expected Fiscal Year Alignment is a part, that we believe will transform how we work across our business and contribute to all of our strategic priorities. Due to the nature, scope and magnitude of this investment, these costs are incremental transformational costs that are far in excess of the historical normal level of spending to support operations and are not expected to recur in the foreseeable future.
(c) For the twelve months ended December 31, 2025, represents charges related to a transition from internal to external innovation and manufacturing of certain products and the closure of a related site, included inRestructuring charges and certain acquisition and divestiture-related costs, as well as charges related to our aquaculture product portfolio included inOther (income)/deductions–net.
For the twelve months ended December 31, 2024, represents charges related to our aquaculture product portfolio, included inOther (income)/deductions–net.
(d) Represents a net loss related to the sale of our medicated feed additive product portfolio, certain water soluble products and related assets in 2024, included inOther (income)/deductions–net.
(e) Included inProvision for taxes on income. Income taxes include the tax effect of the associated pre-tax amounts, calculated by determining the jurisdictional location of the pre-tax amounts and applying that jurisdiction's applicable tax rate. Income taxes inCertain significant itemsalso includes:
For the twelve months ended December 31, 2024, includes a tax expense related to the divestiture of the medicated feed additive product portfolio, certain water soluble products and related assets.
ZOETIS INC.ADJUSTED SELECTED COSTS AND EXPENSES(a)(UNAUDITED)(millions of dollars)
Three Months EndedDecember 31, % Change
2025 2024 Total ForeignExchange Operational(b) Divestitures OrganicOperational(c)
Adjusted cost of sales $ 708 $ 706 —% 1% (1)%
As a percent of revenue 29.7 % 30.5 % NA NA NA
Adjusted SG&A expenses 615 619 (1)% 1% (2)%
Adjusted R&D expenses 199 186 7% 2% 5%
Adjusted net income 648 632 3% 1% 2% (2 )% 4 %
Twelve Months EndedDecember 31, % Change
2025 2024 Total ForeignExchange Operational(b) Divestitures OrganicOperational(c)
Adjusted cost of sales $ 2,657 $ 2,714 (2)% (3)% 1%
As a percent of revenue 28.1 % 29.3 % NA NA NA
Adjusted SG&A expenses 2,344 2,301 2% —% 2%
Adjusted R&D expenses 696 684 2% 1% 1%
Adjusted net income 2,847 2,693 6% 2% 4% (3 )% 7 %
(a) Adjusted cost of sales, adjusted selling, general, and administrative (SG&A) expenses, adjusted research and development (R&D) expenses, and adjusted net income (non-GAAP financial measures) are defined as the corresponding reported U.S. GAAP income statement line items excluding purchase accounting adjustments, acquisition and divestiture-related costs, and certain significant items. These adjusted income statement line item measures are not, and should not be viewed as, substitutes for the corresponding U.S. GAAP line items. The corresponding GAAP line items and reconciliations of reported to adjusted information are provided in Condensed Consolidated Statements of Income and Reconciliation of GAAP Reported to Non-GAAP Adjusted Information.
(b) Operational results (a non-GAAP financial measure) is defined as results excluding the impact of foreign exchange.
(c) Organic operational results (a non-GAAP financial measure) is defined as results excluding the impact of foreign exchange and certain acquisitions and divestitures.
ZOETIS INC.2026GUIDANCE
Selected Line Items(millions of dollars, except per share amounts) Full Year 2026
Revenue $9,825 to $10,025
Organic operational growth(a) 3% to 5%
Adjusted cost of sales as a percentage of revenue(b) Approximately 28.0%
Adjusted SG&A expenses(b) $2,430 to $2,490
Adjusted R&D expenses(b) $715 to $725
Adjusted interest expense and other (income)/deductions-net(b) Approximately $200
Effective tax rate on adjusted income(b) Approximately 20.5%
Adjusted diluted EPS(b) $7.00 to $7.10
Adjusted net income(b) $2,975 to $3,025
Organic operational growth(a)(c) 3% to 6%
Certain significant items and acquisition and divestiture-related costs(d) Approximately $65
Reported diluted EPS $6.65 to $6.75
The guidance reflects foreign exchange rates as of January 20, 2026.
Reconciliations of 2026 reported guidance to 2026 adjusted guidance follows:
(millions of dollars, except per share amounts) Reported Certain significant items and acquisition and divestiture-related costs(d) Purchase accounting Adjusted(b)
Cost of sales as a percentage of revenue ~ 28.2% ~ (0.2%) ~ 28.0%
SG&A expenses $2,453 to $2,513 ~ $(12) ~ $(11) $2,430 to $2,490
R&D expenses $717 to $727 ~ $(2) $715 to $725
Interest expense and other (income) / deductions ~ $200 ~ $200
Effective tax rate ~ 20.7% ~ (0.2%) ~ 20.5%
Diluted EPS $6.65 to $6.75 ~ $0.14 ~ $0.21 $7.00 to $7.10
Net income attributable to Zoetis $2,825 to $2,875 ~ $60 ~ $90 $2,975 to $3,025
(a) Organic operational results (a non-GAAP financial measure) excludes the impact of foreign exchange and certain acquisitions and divestitures.
(b) Adjusted net income and its components and adjusted diluted EPS are defined as reported U.S. GAAP net income and its components and reported diluted EPS excluding purchase accounting adjustments, acquisition and divestiture-related costs and certain significant items. Adjusted cost of sales, adjusted SG&A expenses, adjusted R&D expenses, and adjusted interest expense and other (income)/deductions-net are income statement line items prepared on the same basis, and, therefore, components of the overall adjusted income measure. Despite the importance of these measures to management in goal setting and performance measurement, adjusted net income and its components and adjusted diluted EPS are non-GAAP financial measures that have no standardized meaning prescribed by U.S. GAAP and, therefore, have limits in their usefulness to investors. Because of the non-standardized definitions, adjusted net income and its components and adjusted diluted EPS (unlike U.S. GAAP net income and its components and diluted EPS) may not be comparable to the calculation of similar measures of other companies. Adjusted net income and its components and adjusted diluted EPS are presented solely to permit investors to more fully understand how management assesses performance. Adjusted net income and its components and adjusted diluted EPS are not, and should not be viewed as, substitutes for U.S. GAAP net income and its components and diluted EPS.
(c) We do not provide a reconciliation of forward-looking non-GAAP adjusted net income organic operational results to the most directly comparable U.S. GAAP reported financial measure because we are unable to calculate with reasonable certainty the foreign exchange impact of unusual gains and losses, acquisition and divestiture-related expenses, potential future asset impairments and other certain significant items, without unreasonable effort. The foreign exchange impacts of these items are uncertain, depend on various factors, and could have a material impact on U.S. GAAP reported results for the guidance period.
(d) Primarily includes certain nonrecurring costs related to acquisitions, divestitures and other charges.
ZOETIS INC.CONSOLIDATED REVENUE BY SEGMENT(a)AND SPECIES(UNAUDITED)(millions of dollars)
Three Months EndedDecember 31, % Change
2025 2024 Total ForeignExchange Operational(b) Divestitures OrganicOperational(c)
Revenue:
Companion Animal $ 1,601 $ 1,570 2 % 1 % 1 % % 1 %
Livestock 756 726 4 % 1 % 3 % (6 )% 9 %
Contract Manufacturing & Human Health 30 21 43 % 6 % 37 % % 37 %
Total Revenue $ 2,387 $ 2,317 3 % 1 % 2 % (2 )% 4 %
U.S.
Companion Animal $ 1,002 $ 1,008 (1 )% % (1 )% % (1 )%
Livestock 234 249 (6 )% % (6 )% (9 )% 3 %
Total U.S. Revenue $ 1,236 $ 1,257 (2 )% % (2 )% (2 )% %
International
Companion Animal $ 599 $ 562 7 % 3 % 4 % % 4 %
Livestock 522 477 9 % 2 % 7 % (5 )% 12 %
Total International Revenue $ 1,121 $ 1,039 8 % 3 % 5 % (2 )% 7 %
Companion Animal:
Dogs and Cats $ 1,500 $ 1,477 2 % 1 % 1 %
Horses 101 93 9 % 3 % 6 %
Total Companion Animal Revenue $ 1,601 $ 1,570 2 % 1 % 1 %
Livestock:
Cattle $ 415 $ 399 4 % 1 % 3 %
Swine 125 128 (2 )% 2 % (4 )%
Poultry 117 117 % 1 % (1 )%
Fish 81 65 25 % 5 % 20 %
Sheep and other 18 17 6 % (3 )% 9 %
Total Livestock Revenue $ 756 $ 726 4 % 1 % 3 %
(a) For a description of each segment, see Zoetis' most recent Annual Report on Form 10-K.
(b) Operational revenue results (a non-GAAP financial measure) is defined as revenue results excluding the impact of foreign exchange.
ZOETIS INC.CONSOLIDATED REVENUE BY SEGMENT(a)AND SPECIES(UNAUDITED)(millions of dollars)
Twelve Months EndedDecember 31, % Change
2025 2024 Total ForeignExchange Operational(b) Divestitures OrganicOperational(c)
Revenue:
Companion Animal $ 6,587 $ 6,278 5 % % 5 % % 5 %
Livestock 2,764 2,898 (5 )% (2 )% (3 )% (11 )% 8 %
Contract Manufacturing & Human Health 116 80 45 % % 45 % % 45 %
Total Revenue $ 9,467 $ 9,256 2 % (1 )% 3 % (3 )% 6 %
U.S.
Companion Animal $ 4,220 $ 4,054 4 % % 4 % % 4 %
Livestock 877 1,020 (14 )% % (14 )% (18 )% 4 %
Total U.S. Revenue $ 5,097 $ 5,074 % % % (4 )% 4 %
International
Companion Animal $ 2,367 $ 2,224 6 % (1 )% 7 % % 7 %
Livestock 1,887 1,878 % (2 )% 2 % (8 )% 10 %
Total International Revenue $ 4,254 $ 4,102 4 % (1 )% 5 % (3 )% 8 %
Companion Animal:
Dogs and Cats $ 6,283 $ 5,993 5 % % 5 %
Horses 304 285 7 % 1 % 6 %
Total Companion Animal Revenue $ 6,587 $ 6,278 5 % % 5 %
Livestock:
Cattle $ 1,492 $ 1,531 (3 )% (2 )% (1 )%
Swine 466 516 (10 )% 9 % (19 )%
Poultry 432 527 (18 )% (1 )% (17 )%
Fish 286 242 18 % 2 % 16 %
Sheep and other 88 82 7 % (3 )% 10 %
Total Livestock Revenue $ 2,764 $ 2,898 (5 )% (8 )% 3 %
(a) For a description of each segment, see Zoetis' most recent Annual Report on Form 10-K.
(b) Operational revenue results (a non-GAAP financial measure) is defined as revenue results excluding the impact of foreign exchange.
ZOETIS INC.CONSOLIDATED REVENUE BY KEY INTERNATIONAL MARKETS(UNAUDITED)(millions of dollars)
Three Months EndedDecember 31, % Change
2025 2024 Total ForeignExchange Operational(a)
Total International $ 1,121 $ 1,039 8 % 3 % 5 %
Australia 84 80 5 % (3 )% 8 %
Brazil 112 113 (1 )% 5 % (6 )%
Canada 80 75 7 % (2 )% 9 %
Chile 40 30 33 % 3 % 30 %
China 50 65 (23 )% % (23 )%
France 52 45 16 % 8 % 8 %
Germany 65 59 10 % 6 % 4 %
Italy 35 34 3 % 7 % (4 )%
Japan 39 38 3 % (1 )% 4 %
Mexico 44 40 10 % 6 % 4 %
Spain 37 30 23 % 8 % 15 %
United Kingdom 89 84 6 % 3 % 3 %
Other Developed 182 151 21 % 6 % 15 %
Other Emerging 212 195 9 % % 9 %
Twelve Months EndedDecember 31, % Change
2025 2024 Total ForeignExchange Operational(a)
Total International $ 4,254 $ 4,102 4 % (1 )% 5 %
Australia 329 319 3 % (4 )% 7 %
Brazil 393 414 (5 )% (6 )% 1 %
Canada 290 277 5 % (3 )% 8 %
Chile 139 123 13 % (1 )% 14 %
China 227 270 (16 )% (1 )% (15 )%
France 165 156 6 % 3 % 3 %
Germany 236 225 5 % 3 % 2 %
Italy 137 129 6 % 3 % 3 %
Japan 154 147 5 % 1 % 4 %
Mexico 160 169 (5 )% (6 )% 1 %
Spain 145 130 12 % 4 % 8 %
United Kingdom 325 314 4 % 3 % 1 %
Other Developed 641 564 14 % 2 % 12 %
Other Emerging 913 865 6 % (2 )% 8 %
(a) Operational revenue results (a non-GAAP financial measure) is defined as revenue results excluding the impact of foreign exchange.
ZOETIS INC.SEGMENT(a)EARNINGS(UNAUDITED)(millions of dollars)
Three Months EndedDecember 31, % Change
2025 2024 Total ForeignExchange Operational(b)
U.S.:
Revenue $ 1,236 $ 1,257 (2 )% % (2 )%
Cost of sales 213 229 (7 )% % (7 )%
Gross profit 1,023 1,028 % % %
Gross margin 82.8 % 81.8 %
Operating expenses 193 212 (9 )% % (9 )%
Other (income)/deductions-net (3 ) * * *
U.S. Earnings $ 830 $ 819 1 % % 1 %
International:
Revenue $ 1,121 $ 1,039 8 % 3 % 5 %
Cost of sales 365 336 9 % 1 % 8 %
Gross profit 756 703 8 % 4 % 4 %
Gross margin 67.4 % 67.7 %
Operating expenses 183 180 2 % 3 % (1 )%
Other (income)/deductions-net (1 ) * * *
International Earnings $ 574 $ 523 10 % 4 % 6 %
Total Reportable Segments $ 1,404 $ 1,342 5 % 2 % 3 %
Other business activities(c) (159 ) (151 ) 5 %
Reconciling Items:
Corporate(d) (342 ) (320 ) 7 %
Purchase accounting adjustments(e) (31 ) (33 ) (6 )%
Acquisition and divestiture-related costs(f) (1 ) (6 ) (83 )%
Certain significant items(g) (22 ) (2 ) *
Other unallocated(h) (88 ) (98 ) (10 )%
Total Earnings(i) $ 761 $ 732 4 %
(a) For a description of each segment, see Zoetis' most recent Annual Report on Form 10-K.
(b) Operational results (a non-GAAP financial measure) is defined as results excluding the impact of foreign exchange.
(c) Other business activities reflect the research and development costs managed by our research and development organization, as well as our contract manufacturing business and human health business.
(d) Corporate includes, among other things, certain costs associated with information technology, administration expenses, interest income and expense, certain compensation costs and other costs not charged to our operating segments.
(e) Purchase accounting adjustments include certain charges related to the amortization of fair value adjustments to inventory, intangible assets and property, plant and equipment not charged to our operating segments.
(f) Acquisition and divestiture-related costs include costs associated with acquiring and integrating newly acquired businesses, such as transaction costs and integration costs, as well as costs associated with divesting and disintegrating a portion of our business.
(g) Certain significant items includes substantive, unusual items that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis. Such items primarily include certain asset impairment charges, restructuring charges and implementation costs associated with cost-reduction/productivity initiatives that are not associated with an acquisition, costs related to our business process transformation program, as well as the impact of divestiture gains and losses.
(h) Includes overhead expenses associated with our global manufacturing and supply operations not directly attributable to an operating segment, as well as certain procurement costs.
(i) Defined as income before provision for taxes on income.
* Calculation not meaningful.
ZOETIS INC.SEGMENT(a)EARNINGS(UNAUDITED)(millions of dollars)
Twelve Months EndedDecember 31, % Change
2025 2024 Total ForeignExchange Operational(b)
U.S.:
Revenue $ 5,097 $ 5,074 % % %
Cost of sales 842 936 (10 )% % (10 )%
Gross profit 4,255 4,138 3 % % 3 %
Gross margin 83.5 % 81.6 %
Operating expenses 817 805 1 % % 1 %
Other (income)/deductions-net (3 ) * * *
U.S. Earnings $ 3,438 $ 3,336 3 % % 3 %
International:
Revenue $ 4,254 $ 4,102 4 % (1 )% 5 %
Cost of sales 1,312 1,312 % (5 )% 5 %
Gross profit 2,942 2,790 5 % 1 % 4 %
Gross margin 69.2 % 68.0 %
Operating expenses 677 671 1 % (1 )% 2 %
Other (income)/deductions-net 1 1 * * *
International Earnings $ 2,264 $ 2,118 7 % 2 % 5 %
Total Reportable Segments $ 5,702 $ 5,454 5 % 1 % 4 %
Other business activities(c) (562 ) (562 ) %
Reconciling Items:
Corporate(d) (1,240 ) (1,213 ) 2 %
Purchase accounting adjustments(e) (128 ) (140 ) (9 )%
Acquisition and divestiture-related costs(f) (2 ) (18 ) (89 )%
Certain significant items(g) (82 ) (79 ) 4 %
Other unallocated(h) (328 ) (309 ) 6 %
Total Earnings(i) $ 3,360 $ 3,133 7 %
(a) For a description of each segment, see Zoetis' most recent Annual Report on Form 10-K.
(b) Operational results (a non-GAAP financial measure) is defined as results excluding the impact of foreign exchange.
(c) Other business activities reflect the research and development costs managed by our research and development organization, as well as our contract manufacturing business and human health business.
(d) Corporate includes, among other things, certain costs associated with information technology, administration expenses, interest income and expense, certain compensation costs and other costs not charged to our operating segments.
(e) Purchase accounting adjustments include certain charges related to the amortization of fair value adjustments to inventory, intangible assets and property, plant and equipment not charged to our operating segments.
(f) Acquisition and divestiture-related costs include costs associated with acquiring and integrating newly acquired businesses, such as transaction costs and integration costs, as well as costs associated with divesting and disintegrating a portion of our business.
(g) Certain significant items includes substantive, unusual items that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis. Such items primarily include certain asset impairment charges, restructuring charges and implementation costs associated with cost-reduction/productivity initiatives that are not associated with an acquisition, costs related to our business process transformation program, as well as the impact of divestiture gains and losses.
(h) Includes overhead expenses associated with our global manufacturing and supply operations not directly attributable to an operating segment, as well as certain procurement costs.
(i) Defined as income before provision for taxes on income.
* Calculation not meaningful.

Frequently Asked Questions

What were Zoetis' revenues for Q4 2025?

Zoetis reported revenues of $2.4 billion for Q4 2025.

What is the adjusted net income for full year 2025?

The adjusted net income for full year 2025 was $2.8 billion.

What new products did Zoetis receive approvals for?

Zoetis received approvals for Lenivia and Portela, long-acting OA pain products.

What guidance did Zoetis provide for 2026?

Zoetis provided full year 2026 guidance reflecting current foreign exchange rates.

Last updated: Feb 12, 2026