Clinical Results on the use of Bacterin's OsteoSponge for Foot and Ankle Arthrodeses Procedures Published in Orthopedics Today

Clinical Results on the use of Bacterin's OsteoSponge

for Foot and Ankle Arthrodeses Procedures Published in Orthopedics Today

BELGRADE, Mont., March 20, 2014 /PRNewswire/ -- Bacterin

International Holdings, Inc. (NYSE MKT: BONE), a leader in the development of revolutionary bone graft materials and bioactive

coatings for medical applications, announces that results utilizing OsteoSponge bone graft for foot and

ankle arthrodeses procedures has been published in the peer-reviewed journal Orthopedics. This is the second publication

for Bacterin that highlights clinical outcomes of OsteoSponge for foot and ankle fusion procedures.

The article reports a prospective analysis of 25 patients who

underwent foot and ankle arthrodesis involving 45 total joints. Results indicated that 96% of patients showed radiographic fusion

at 6 and 12 months (24/25 patients) postoperative assessment, with a 97.4% overall fusion rate (44 out of 45 joints fused). Pain

was assessed pre and postoperatively via visual analog scale (VAS), with statistically significant improvements at 6 and 12 months

relative to preoperative pain scores. Functional outcomes were significantly improved at 6 and 12 months compared with preoperative

assessment according to American Orthopaedic Foot and Ankle Society (AOFAS) scores.

"Bacterin has made a commitment to patients, healthcare

providers, and healthcare facilities alike to provide best-in-class products supported by proven clinical outcomes." said

Dr. Gregory Juda, Chief Scientific Officer for Bacterin. "We have spent a considerable amount of effort and resources supporting

the clinical efficacy of our products through peer-reviewed publications in recent years and the results of this study further

serve as testament to our role as a leader in the orthobiologic sector."

The full article may be accessed using the link below or located

in the March 2014 issue of Orthopedics. http://www.healio.com/~/media/Journals/ORTHO/2014/3_March/10_3928_01477447_20140225_54/10_3928_01477447_20140225_54.pdf

About Bacterin International

Bacterin International

Holdings, Inc. (NYSE MKT: BONE) develops, manufactures and markets biologics products to domestic and international markets. These

products are used in a variety of applications including enhancing fusion in spine surgery, relief of back pain, promotion of bone

growth in foot and ankle surgery, promotion of cranial healing following neurosurgery and subchondral repair in knee and other

Bacterin's Medical Device

division develops, employs, and licenses coatings for various medical device applications. For further information, please visit www.bacterin.com.

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their nature involve risks and uncertainties, and actual results may differ materially depending on a variety of important factors,

including, among others: the Company's ability to meet its existing and anticipated contractual obligations, including financial

covenant and other obligations contained in the Company's secured lending facility; the Company's ability to manage

cash flow and achieve profitability; the Company's ability to develop, market, sell and distribute desirable applications, products

and services and to protect its intellectual property; the ability of the Company's sales force to achieve expected results; the

ability of the Company's customers to pay and the timeliness of such payments; the Company's ability to obtain financing as and

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with appropriate skills and expertise; the Company's ability to successfully conclude government investigations; the impact

of changes in market, legal and regulatory conditions and in the applicable business environment, including actions of competitors;

and other factors. Additional risk factors are listed in the Company's Annual Report on Form 10-K and Quarterly Reports on Form

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forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated

events, except as required by law.