Bacterin Announces Preclinical Results on the use of OsteoSelect DBM Putty Published in The Journal of Craniofacial Surgery

Announces Preclinical Results on the use of OsteoSelect DBM

Putty Published in The Journal of Craniofacial Surgery

BELGRADE, Mont., April 23, 2014 -- Bacterin

International Holdings, Inc. (NYSE MKT: BONE), a leader in the development of revolutionary bone graft materials and bioactive

coatings for medical applications, announced today that positive results utilizing OsteoSelect Demineralized

Bone Matrix Putty bone graft for cranial defect repair has been published in the peer-reviewed Journal of Craniofacial Surgery.

This is the first peer reviewed publication evaluating the performance of OsteoSelect DBM to date.

The article compares the bone regeneration potential of OsteoSelect

DBM to a competitive synthetic bone graft substitute (Novabone Putty) in a rabbit cranial defect model using semi-quantitative

histology and quantitative histomorphometry evaluated at 43 and 91 days post-implantation. Defects filled with OsteoSelect

DBM were histologically associated with less inflammation and fibrous tissue in the defect and more new bone than the synthetic

counterpart at both time points. Histomorphometric analysis indicated the defects filled with OsteoSelect DBM were associated

with significantly more bone formation at day 43 (70.7% vs 40.7%) and at day 91 (70.4% vs 39.9%) relative to the synthetic bone

is proud to announce yet another peer-reviewed publication supporting the efficacy of our products," said

Gregory Juda, Chief Scientific Officer for Bacterin. "We believe that the results of this animal study further support the

superiority of Bacterin's allograft derived bone grafts over competitive products of synthetic origin. We look forward to

substantiating the exceptional performance of the OsteoSelect product line in future clinical reports."

The full article may be accessed using the link below or located

in the March 2014 issue of The Journal of Craniofacial Surgery.

About Bacterin International

Bacterin International

Holdings, Inc. (NYSE MKT: BONE) develops, manufactures and markets biologics products to domestic and international markets. These

products are used in a variety of applications including enhancing fusion in spine surgery, relief of back pain, promotion of bone

growth in foot and ankle surgery, promotion of cranial healing following neurosurgery and subchondral repair in knee and other

Bacterin's Medical Device

division develops, employs, and licenses coatings for various medical device applications. For further information, please visit www.bacterin.com.

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including, among others: the Company's ability to meet its existing and anticipated contractual obligations, including financial

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conclude government investigations; the impact of changes in market, legal and regulatory conditions and in the applicable business

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