September 2015 www.xtlbio.com

September 2015 www.xtlbio.com

XTL Biopharmaceuticals (NASDAQ: XTLB) (TASE: XTL)

Looking Statements The following slides contain forward-looking statements, about XTL's expectations, beliefs or intentions

regarding, among other things, its product development efforts, business, financial condition, results of operations, strategies

or prospects. Forward-looking statements can be identified by the use of forward-looking words such as "believe," "expect,"

"intend," "plan," "may," "should" or "anticipate" or their negatives or other

variations of these words or other comparable words or by the fact that these statements do not relate strictly to historical

or current matters. Forward-looking statements relate to anticipated or expected events, activities, trends or results as of the

date they are made. Because forward looking statements relate to matters that have not yet occurred, these statements are inherently

subject to risks and uncertainties that could cause XTL's actual results to differ materially from any future results expressed

or implied by the forward-looking statements. Many factors could cause XTL's actual activities or results to differ materially

from the activities and results anticipated in such forward-looking statements, including, but not limited to, the factors summarized

in XTL's filings with the SEC and in its periodic filings with the TASE. In addition, XTL operates in an industry sector

where securities values are highly volatile and may be influenced by economic and other factors beyond its control. XTL does not

undertake any obligation to publicly update these forward-looking statements, whether as a result of new information, future events

or otherwise. Please see the risk factors associated with an investment in our ADSs or ordinary shares, which are included in

our Annual Report on Form 20F as filed with the U.S. Securities and Exchange Commission on April 28 2015.

XTLbio is a clinical-stage biotech company focused on the development of pharmaceutical products for the treatment of unmet

clinical needs in large markets -

Our lead drug is a "world-class" clinical asset: hCDR1 for treatment of SLE (lupus) -

- SLE is a significant unmet medical need; has shown high interest from

- GSK acquired HGS in 2012 primarily for its SLE drug Benlysta for $3

There is no current effective solution on the market and weak competitive pipeline -

hCDR1 is a novel compound with a unique mechanism of action -

- hCDR1 has clinical data on >400 patients -

Favorable safety profile and well tolerated by patients -

"Demonstrated efficacy in one and possibly more clinically meaningful endpoints" (Lupus Science &

Medicine Journal - August 2015) -

We need to replicate the results achieved in a previous Phase 2b trial -

We have reason to believe we can do even better

Corporate Snapshot Headquarters:

Raanana, Israel ADRs trading on the NASDAQ (XTLB) and Ordinary Shares on the Tel-Aviv Stock Exchange (XTL) Cash $4.8 million

(as of 6/30/2015) In Q2 2015 raised $4 million from a large US healthcare fund and existing shareholders HC Wainwright research

analyst initiated coverage with a Buy recommendation and a price target of $6 per ADR -

Capitalization: 273,525,799 Shares Outstanding* No

debt or preferred Experienced Management Team World Class Clinical Advisory Board * Each ADS represents 20 Ordinary Shares

Josh Levine, CEO CEO, Proteologics; Senior

Director, Teva Pharmaceuticals (Innovative Ventures); Partner, Platinum Neurone Ventures; Corporate Finance Head, Patterson Travis;

Attorney, WF&G - David

Kestenbaum, CPA & MBA, CFO CFO, ZenithSolar; Finance Director, Colbar Lifescience (division of J&J (NYSE:JNJ)); CFO,

ZAG Industries (division of Stanleyworks (NYSE:SWK)); CFO, Lever Israel (division of Unilever (NYSE:UN)); Sr. Associate, PwC,

Ben Am, MSc, Clinical Development Lead VP Clinical Development, BioCancell; Director, Teva Pharmaceuticals Ltd.; VP

Clinical, Topspin; Associate Director, Novartis (development of Gleevec ) -

Prof. Moshe Mittelman, MD, Medical Director

Physician and Scientist, Internationally renowned haematologist. Director, Dept. of Internal Medicine at Ichilov Hospital

(Tel Aviv Sourasky Medical Center). Director, Gaon Holdings (TASE: GAON). Formerly Member of the Public Health Reimbursement Committee

and Chairman of the Israeli Internal Medicine Association

Clinical Advisory Board -

Dr. Daniel Wallace, Cedars-Sinai Medical Center

Largest lupus practice of its kind in the US; currently running >30 clinical trials Served as Chairman of the Lupus Foundation

of America, receiving the Lupus Foundation of America Award, Achievement Award of the Lupus Research Institute and others "I

am privileged to join the team at XTL to help advance what I believe to be one of the most promising Lupus drug candidates in

recent history. The data shown in earlier trials is encouraging and could potentially be a disruptive solution to a largely unmet

medical need." - Professor

David Isenberg, University College London Hospitals Chair of the British Isles Assessment Group (BILAG). President of the

British Society for Rheumatology from 2004 - 2006 Chaired the Society's Biologics Register Committee from 2006 -

2011 Received the 2010 Evelyn Hess Prize from the Lupus Foundation of America and the Rodger Demers Prize (Canada), in 2012. "I

am happy to serve as a consultant for XTL's Phase II trial testing for hcDR1 using the BILAG index because it has shown

encouraging results when used during the previously conducted PRELUDE trial." -

Dr. Murray Urowitz, University of Toronto; Lupus

Clinic at Toronto Western Hospital Established the University of Toronto Lupus Clinic and Lupus Databank Research Program.

Founding member/president of numerous lupus-related associations and the recipient of numerous awards for his contributions to

lupus research. "The continued development of XTL's hCDR1 has the medical community eagerly waiting to learn the efficacy

of the drug in its planned Phase II trial."

hCDR1 for the treatment of Lupus

SLE: General & Affected Organs & Symptoms Systemic

"Lupus" Erythematosus (SLE) is a chronic, debilitating inflammatory autoimmune disease, resulting in rheumatologic,

dermatological and end-organ manifestations 8

Lupus: Market Overview

1.5 million patients in U.S. (5 million worldwide) varying across ethnicities/geographies Vast majority are women /

majority between ages of 15 and 45 - Prognosis

Dermatologic & musculoskeletal manifestation most common early on End organs become involved as disease progresses -

Most common causes of death -

Renal failure, Cardiovascular disease, CNS disorders, Intercurrent

infections 10-year survival rate for ~90% of patients - Market

expected to grow dramatically SLE Drug Market Growth ($M)2 1Lupus Foundation of America 2 Decision

Resources 2013 5,000 4,000 3,000 2,000 1,000 900 2012 2022 16.1% CAGR

Lupus: Competitive Landscape

effective treatments for lupus in the market: - Current

treatments: corticosteroids, cytotoxic immune-suppressants (palliative care) -

Problems with current treatments: non specific, severe side effects

(hypertension, osteoporosis, bone marrow suppression, increased cancer risk, etc.) -

(HGS/GSK): approved by 35 FDA 3/2011 30 Only approved drug against Lupus in the last 50+ years Market penetration is

slower than expected (2014 sales of $268M 20 vs. expected blockbuster) 25 15 -

Weak pipeline: primarily B-cell inhibitors - like Benlysta

Phase III failures: UCB/Lilly 5 0 Stage of Development # of Protocols Phase III Phase II Phase I Preclinical

0 5 10 15 20 25 30 35 Phase III Phase II Phase I Preclinical Source: Global Markets Direct/H2 2015

hCDR1: Unique Mechanism of Action (MOA)

hCDR1 is a peptide that down-regulates the SLE-related autoimmune process; potential to be "first in class" and

"best in class" drug Specific upstream immunomodulation through the generation of regulatory T cells Developed

by Prof. Edna Mozes of the The Weizmann Institute of Science (Israel) >40 peer reviewed journal articles; >200 animal experiments

IP: Minimum of data exclusivity (~7 years US/10 years EU) with plans to extend XTL obtained exclusive license from Yeda Research

and Development Co. (1/2014)

Clinical Trial History of hCDR1

trials completed (by Teva): Phase Ia, Ib trials and a Phase II trial Studies included over 400 patients Demonstrated to be well

tolerated by patients and to have a favorable safety profile - Phase

II (PRELUDE) trial Did not meet primary endpoint (SLEDAI) Did not enforce steroid withdrawal algorithm Encouraging results in

secondary clinical endpoint, the BILAG index (see below) - 0.5

mg weekly dose showed a substantial effect - Opportunity

for hCDR1 Teva returned hCDR1 to Yeda in 2009 Thereafter, in 2010, FDA published guidelines that BILAG should be the primary endpoint