Xenetic Biosciences, Inc. Reports Second Quarter 2021 Financial Results and Provides Business Update - Continued execution on XCART pre-clinical development plan and progress toward IND-enabling studies - Strong royalty

Xenetic Biosciences,

Inc. Reports Second Quarter 2021 Financial Results and Provides Business Update

- Continued execution on XCART

pre-clinical development plan and progress toward IND-enabling studies

- Strong royalty growth with PolyXen

- Bolstered cash position with recently

completed $12.5 million private placement

MA - (August 13, 2021) - Xenetic Biosciences, Inc. (NASDAQ: XBIO)

("Xenetic" or the "Company"), a biopharmaceutical company focused on advancing XCART , a personalized CAR

T platform technology engineered to target patient- and tumor-specific neoantigens, today reported its financial results for the second

quarter of 2021 and provided a corporate update.

"Over the course of the second quarter,

we continued to execute our innovative and differentiated XCART program, and the technical progress we've accomplished brings us

closer to the critical milestone of conducting IND-enabling studies in the United States. In light of that progress, we are taking important

steps to validate the key workflow and manufacturing components that we believe will maximize the XCART opportunity," commented

Jeffrey Eisenberg, Chief Executive Officer of Xenetic. "Additionally, with our recently completed $12.5 million private placement

and the royalty growth we have seen through our PolyXen license agreement, I believe we are in a strong position moving forward to maintain

optionality and execute on advancing our development program."

Technology Overview: Significantly differentiated, proprietary approach to personalized CAR T lymphoma therapy targeting

tumor-specific neoantigens that target independently of CD19 or other surface antigens that are common to both normal and malignant B-cells.

Lead program for Non-Hodgkin lymphoma, an area of significant unmet need, with the potential to address an initial global market opportunity

of over $7 billion annually.[1]

Triangle Insights: Company Commissioned Market Report

"Through the experience gained in Eastern

Europe, the ongoing work at Scripps, and the enthusiasm of our expanding network of subject matter experts and contract development partners,

we've made considerable progress in advancing toward conducting IND-enabling studies for XCART," added Curtis Lockshin, Ph.D.,

Chief Scientific Officer of Xenetic. "We look forward to building on that momentum as we continue to advance XCART beyond its academic

foundation toward a commercially viable platform, including a clinical manufacturing process for generating patient-specific CAR T products."

PolyXen Platform Technology:

Patent-protected platform technology designed for protein or peptide therapeutics, enabling next-generation biological drugs by prolonging

a drug's circulating half-life and potentially improving other pharmacological properties.

Summary of Financial Results for Second Quarter

Net loss for the quarter

ended June 30, 2021 was approximately $1.1 million. Research and development expenses for the three months ended June 30, 2021 increased

by approximately $0.2 million, or 70.4%, to $0.5 million from $0.3 million in the comparable quarter in 2020. The increase was due to

the Company's increased spending on the XCART platform technology. General and administrative expenses for the three months ended

June 30, 2021 was $0.9 million, increasing $0.1 million, or 13.1%, compared to the same period in the prior year. The increase was primarily

due to reduced general and administrative expenses by $0.1 million during the three months ended June 30, 2020 due to a gain on settlement

of certain vendor amounts to close out our XBIO-101 trial during such period. At June 30, 2021, the Company reported working capital was

approximately $9.2 million. The Company ended the quarter with approximately $9.3 million of cash. Subsequent to quarter end, the Company

completed a $12.5 million private placement of common stock and warrants to purchase common stock resulting in approximately $11.4 million

of net proceeds to the Company.

About Xenetic Biosciences

Xenetic Biosciences, Inc. is a biopharmaceutical company focused on progressing XCART , a personalized CAR T platform technology

engineered to target patient- and tumor-specific neoantigens. The Company is initially advancing cell-based therapeutics targeting the

unique B-cell receptor on the surface of an individual patient's malignant tumor cells for the treatment of B-cell lymphomas. XCART has

the potential to fuel a robust pipeline of therapeutic assets targeting high-value oncology indications.

Additionally, Xenetic is leveraging PolyXen ,

its proprietary drug delivery platform, by partnering with biotechnology and pharmaceutical companies. PolyXen has demonstrated

its ability to improve the half-life and other pharmacological properties of next-generation biologic drugs. The Company has an exclusive

license agreement with Takeda Pharmaceuticals Co. Ltd. in the field of coagulation disorders and receives royalty payments under this

For more information, please visit the Company's

website at www.xeneticbio.com and connect on Twitter, LinkedIn, and Facebook.

Forward-Looking Statements

This press release contains forward-looking statements that we intend to be subject to the safe harbor provisions of the Private Securities

Litigation Reform Act of 1995. All statements contained in this press release other than statements of historical facts may constitute

forward-looking statements within the meaning of the federal securities laws. These statements can be identified by words such as "expects,"

"plans," "projects," "will," "may," "anticipates," "believes," "should,"

"intends," "estimates," and other words of similar meaning, including, but not limited to, statements regarding: our

progress with respect to our exploratory patient biopsy study in Eastern Europe and any subsequent expansion of the XCART development

program; efforts and expectations regarding process development for clinical CAR T manufacturing; our belief that the XCART platform

has the potential to provide a personalized CAR T therapy targeting cancers with a patient-and tumor-specific approach; our belief that

we are taking the steps necessary to validate the key workflow and manufacturing components that we believe will maximize the XCART opportunity;

our belief that we are in a strong position to maintain optionality and execute on advancing our development program; our expectation

that the work being performed under the collaborations being leveraged in the XCART development program will position the Company

to conduct IND-enabling studies in the United States; our expectations that the Company is advancing a commercially viable platform, including

a clinical manufacturing process for generating patient-specific CAR T products; our plans to initially apply the XCART technology

to advance cell-based therapeutics by targeting the unique B-cell receptor on the surface of an individual patient's malignant tumor

cells for the treatment of B-cell lymphomas; our expectations that XCART has the potential to fuel a robust pipeline of therapeutic

assets targeting high-value oncology indications; our belief that our significantly differentiated, proprietary approach to personalized

CAR T lymphoma therapy for the treatment of multiple tumor types of B-cell Non-Hodgkin lymphoma, an area of significant unmet need, has

the potential to address an initial global market opportunity of over $7 billion annually; and our expectations regarding receipt of royalty

payments under the exclusive license agreement with Takeda Pharmaceuticals Co. Ltd. Any forward-looking statements contained herein are

based on current expectations, and are subject to a number of risks and uncertainties. Many factors could cause our actual activities,

performance, achievements, or results to differ materially from the activities and results anticipated in forward-looking statements.

Important factors that could cause actual activities, performance, achievements, or results to differ materially from such plans, estimates

or expectations include, among others, (1) failure to realize the anticipated potential of the XCART or PolyXen technology;

(2) the ability of the Company to implement its business strategy; (3) failure of Scripps Research and/or Pharmsynthez or the other academic

institutions in Eastern Europe, including Belarus and Russia (as applicable) to perform their obligations under the respective agreements;

(4) failure of the Company and Pharmsynthez to reach agreements with the contract sites on terms favorable to the Company, or at all;

(5) failure of Pharmsynthez to receive approval for its registration for Epolong in Russia or, if approved, to successfully commercialize

and market Epolong; and (6) other risk factors as detailed from time to time in the Company's reports filed with the SEC, including

its annual report on Form 10-K, periodic quarterly reports on Form 10-Q, current reports on Form 8-K and other documents filed with the

SEC. The foregoing list of important factors is not exclusive. In addition, forward-looking statements may also be adversely affected

by general market factors, general economic and business conditions, including potential adverse effects of public health issues, such

as the COVID-19 outbreak on economic activity, competitive product development, product availability, federal and state regulations and

legislation, the regulatory process for new product candidates and indications, manufacturing issues that may arise, patent positions

and litigation, among other factors. The forward-looking statements contained in this press release speak only as of the date the statements

were made, and the Company does not undertake any obligation to update forward-looking statements, except as required by law.

Source: Xenetic Biosciences,