Aerpio Reports Second Quarter 2018 Financial Results and Provides Business Update TIME-2b Clinical Trial of AKB-9778 in Patients with Diabetic Retinopathy Remains on Track; Data in Q2 2019 Partnership for AKB-4924 with G

Aerpio Reports Second Quarter 2018 Financial Results and Provides Business Update

TIME-2b Clinical Trial of AKB-9778 in Patients with

Diabetic Retinopathy Remains on Track; Data in Q2 2019

Partnership for AKB-4924 with

Gossamer Bio Will Accelerate Development of the Compound and Allow Aerpio to Focus on Core Ophthalmology and Diabetes Programs

Recent Equity Financing Strengthens Balance Sheet

Conference Call and Webcast Today, August 14th at 8:30 a.m. EDT

CINCINNATI (BUSINESS WIRE) Aerpio Pharmaceuticals, Inc. (Nasdaq:ARPO), a biopharmaceutical company focused on advancing first-in-class treatments for ocular diseases, today reported financial results for the second quarter ended June 30, 2018 and provided a business update.

We had a busy and productive second quarter at Aerpio, commented Stephen Hoffman, M.D. Ph.D., Chief Executive Officer of Aerpio. Our ongoing

TIME-2b study, evaluating the effect of AKB-9778, our first-in-class Tie2 activator, in

patients with non-proliferative diabetic retinopathy (NPDR) is on schedule, and we expect to report top-line data from the study in the second quarter of 2019.

Dr. Hoffman added, In addition, we announced several important corporate milestones in the second quarter. First, in June, we completed a

partnership with Gossamer Bio for AKB-4924, our HIF-1 alpha compound for inflammatory bowel disease ( IBD ). We believe Gossamer is the ideal partner to

develop AKB-4924 as they have a demonstrated track record of successful therapeutic development in IBD. Our partnership will now allow us to focus our resources on our ophthalmology and diabetes programs

currently in development. Second, we completed an underwritten public offering that resulted in net proceeds to Aerpio of approximately $48.0 million. This will provide funding for the Company through the first quarter of 2020, which we believe

gives us sufficient resources to complete the TIME-2b study on its expected timeframe, finish preparations for our expected Phase 3 program, and continue to advance our earlier pipeline programs, including a

topical formulation of AKB-9778 in glaucoma. Finally, we also up-listed from the OTC to Nasdaq in June, which we believe will give the Company greater visibility as we

move toward the announcement of results from our TIME-2b study.

Recent Company Highlights

2018 Financial Highlights

As of June 30, 2018, cash and cash equivalents totaled $68.8 million, compared to $20.3 million as of

December 31, 2017. Total shares outstanding as of June 30, 2018 were 38.8 million. On July 2, 2018, an additional 1.7 million shares were issued pursuant to the exercise of the underwriters overallotment option in the

Revenue for the three and six months ended June 30, 2018 of $1.3 million relates to the $20.0 million upfront payment

from Gossamer in consideration of the license agreement for AKB-4924 (the License Agreement ). Pursuant to the terms of the License Agreement and applicable accounting guidance, the

$20.0 million will be recognized over a ninety-day performance period beginning June 25, 2018. The remaining $18.7 million, shown as deferred revenue on the Company s consolidated balance

sheet as of June 30, 2018, is expected to be recognized as revenue during the third quarter of 2018.

For the three months ended June 30, 2018,

operating expenses totaled $7.4 million, including $0.9 million in non-cash stock compensation expense, compared to $5.6 million, including $0.1 million in

non-cash stock compensation expense, for the same period in 2017. For the six months ended June 30, 2018, operating expenses totaled $14.8 million, including $2.0 million in non-cash stock compensation expense, compared to $10.3 million, including $0.3 million in non-cash stock compensation expense, for six months ended June 30,

Research and development expenses for the three months ended June 30, 2018 increased $1.1 million,

or 33%, compared to the same period in 2017. Research and development expenses for the six months ended June 30, 2018 increased $2.8 million, or 52%, compared to the six months ended June 30, 2017. The increase in both periods was the

primarily the result of increased spending on the Company s lead program, AKB-9778, currently in Phase 2b development.

General and administrative expenses for the three months ended June 30, 2018 increased $0.7 million, or 30%, compared to the same period in 2017.

General and administrative expenses for the six months ended June 30, 2018 increased $1.7 million, or 34%, compared to the six months ended June 30, 2017. The increase in both periods was primarily attributable to personnel and

Net loss attributable to common shareholders for the three months ended June 30, 2018 was $6.0 million, or $0.22 per share,

compared to a net loss attributable to common shareholders of $5.5 million, or $0.21 per share, for the same period in 2017. Net loss attributable to common shareholders for the six months ended June 30, 2018 was $13.4 million, or

$0.49 per share, compared to a net loss attributable to common shareholders of $11.5 million, or $0.70 per share, for the six months ended June 30, 2017.

Conference Call and Webcast

Aerpio management will host

a live conference call and webcast at 8:30 a.m. EDT today to discuss Aerpio s financial results and provide a general business update.

webcast and a replay may be accessed by visiting Aerpio s website at http://ir.aerpio.com/. Please connect to the Company s website at least 15 minutes prior to the live webcast to ensure adequate time for any software download that

may be needed to access the webcast. Alternatively, please call (877) 216-7943 (U.S.) or (417) 629-5045 (international) to listen to the live conference call. The

conference ID number for the live call is 1372519. Please dial in approximately 10 minutes prior to the call. Telephone replay will be available approximately two hours after the call. To access the replay, please call (855) 859-2056 (U.S.) or (404) 537-3406 (international). The conference ID number for the replay is 1372519.

About Aerpio Pharmaceuticals

Aerpio Pharmaceuticals,

Inc. is a biopharmaceutical company focused on advancing first-in-class treatments for ocular diseases. The Company s lead compound,

AKB-9778, is a small molecule activator of the Tie2 pathway and is in clinical development for the treatment of non-proliferative diabetic retinopathy. For more

information, please visit www.aerpio.com.

AKB-9778 is being developed as a subcutaneous injection for the treatment of

non-proliferative diabetic retinopathy. AKB-9778 binds to and inhibits the intracellular domain of VE-PTP, the most critical

negative regulator of Tie2. AKB-9778 has demonstrated the ability to activate the

Tie2 receptor irrespective of extracellular levels of its binding ligands, angiopoietin-1 (agonist) or

angiopoietin-2 (antagonist) and may be the most efficient pharmacologic approach to activating Tie2.

Diabetic Retinopathy

Diabetic Retinopathy (DR) is a complication of diabetes caused by damage to blood vessels in the retina. DR is the leading cause

of blindness among working-age people. Severity of DR ranges from mild non-proliferative diabetic retinopathy (NPDR) to more advanced proliferative diabetic retinopathy

(PDR), the hallmark of which is the development of new abnormal blood vessels.

Forward Looking Statements

This press release contains forward-looking statements. Statements in this press release that are not purely historical are forward-looking statements. Such

forward-looking statements include, among other things, projections regarding future revenue and financial performance, the Company s long-term growth, the development of the Company s product candidates, including AKB-9778 for non-proliferative diabetic retinopathy or otherwise, the therapeutic potential of the Company s product candidates, including

AKB-9778, the Company s cash position and expected runway, the Company s collaboration with Gossamer Bio, and the Company s listing on Nasdaq. Actual results could differ from those projected in

any forward-looking statements due to several risk factors. Such factors include, among others, the ability to raise the additional funding needed to continue to develop AKB-9778 or other product development

plans, the inherent uncertainties associated with the FDA and drug development process, competition in the industry in which the Company operates, overall market conditions, the maintenance of the Company s collaboration with Gossamer Bio, and

the Company s ability to maintain its listing on Nasdaq. These forward-looking statements are made as of the date of this press release, and the Company assumes no obligation to update the forward-looking statements, or to update the reasons

why actual results could differ from those projected in the forward-looking statements, except as required by law. Investors should consult all the information set forth herein and should also refer to the risk factor disclosures set forth in the

reports and other documents the Company files with the SEC available at www.sec.gov.

AERPIO PHARMACEUTICALS, INC.

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(In thousands, except per share amounts)

AERPIO PHARMACEUTICALS, INC.

CONDENSED CONSOLIDATED BALANCE SHEETS

Pharmaceuticals, Inc.

Burns McClellan, on behalf of Aerpio Pharmaceuticals, Inc.