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EZH2 Inhibitor Monitoring Immunoassay

Key Takeaway: The article discusses the development of the Nu.Q® H3K27Me3 immunoassay, which quantifies circulating H3K27Me3-nucleosomes, important biomarkers for EZH2 and PRC2 inhibitor activity. This automated blood-based assay allows for accurate monitoring of drug efficacy in both cellular and animal models. It is a significant advancement for real-time assessment in cancer therapy development.
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POSITIVE FACTORS

  • Development of a novel immunoassay for monitoring drug efficacy.
  • Non-invasive method for assessing epigenetic drug activity.
  • Supports real-time assessment during clinical development.

Full Press Release Details

We have developed and validated the Nu.Q® H3K27Me3 immunoassay , an automated blood-based assay for quantifying circulating H3K27Me3-nucleosomes—key biomarkers of EZH2 and PRC2 inhibitor activity.
By normalizing results with our Nu.Q® H3.1 assay, we enable accurate, non-invasive monitoring of epigenetic drug efficacy in both cellular and animal models. This platform supports real-time assessment during preclinical and clinical development, offering a powerful tool for advancing targeted cancer therapies.
Learn more about Nu.Q® Discover

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Data Showing the Prognostic Value of its Nu.Q® Cancer Test

Cytokine-induced chromatin accessibility in whole blood neutrophils links to sepsis transcriptional states

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Frequently Asked Questions

What is the Nu.Q® H3K27Me3 immunoassay?

It is an automated blood-based assay for quantifying circulating H3K27Me3-nucleosomes.

How does the immunoassay support cancer therapy?

It allows for accurate, non-invasive monitoring of epigenetic drug efficacy.

What models does the assay work with?

The assay is effective in both cellular and animal models.

What is the significance of real-time assessment?

It provides timely insights during preclinical and clinical development.

Last updated: May 12, 2025