Full Press Release Details
Additional Data from ENZAMET Study Show How Decipher Can Help Metastatic Prostate Cancer Patients Avoid Unnecessary Treatment and Enable More Personalized Care
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--$VCYT#ASCO26--Veracyte, Inc.(NASDAQ: VCYT), a leading cancer diagnostics company, announced today that data from two significant phase III clinical trials using its Prosigna Breast and Decipher Prostate tests will be presented at the 2026 ASCO Annual Meeting in Chicago, taking place May 29 – June 2. TheOPTIMAandENZAMETtrial presentations are expected to provide practice-changing evidence demonstrating how Veracyte’s genomic tests can guide treatment decisions in both early-stage breast cancer and metastatic prostate cancer.
TheOPTIMA studyis a prospective, randomized trial led by University College London (UCL) and supported by the National Institute for Health Research (NIHR). The study enrolled more than 4,400 patients and was designed to address a key clinical question: which patients would benefit from chemotherapy, and which may be able to safely avoid it, and its long-term toxicities. The study results demonstrating how the Prosigna test can guide adjuvant chemotherapy decisions in patients with high-risk breast cancer will be presented by Dr. Rob Stein of UCL and OPTIMA Trial Chief Investigator, on Saturday, May 30 during the breast cancer session.
"The OPTIMA trial results represent a major milestone in precision breast oncology and will provide Level 1A evidence supporting Prosigna-guided treatment decisions," said Kelly Marcom, M.D., Veracyte’s medical director, Breast Cancer. "These findings have the potential to transform how clinicians treat a large population of patients with breast cancer, helping them to personalize their patient’s treatment choices using the genomic insights that the Prosigna test provides."
TheENZAMET trialis an international, prospective, randomized study conducted by the Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP). Dr. Christopher Sweeney of South Australian Immunogenomics Cancer Institute, Adelaide University, will present data on Saturday, May 30 during the Genitourinary Cancer session on Decipher Prostate’s ability to predict treatment benefit with the chemotherapy docetaxel in metastatic, hormone-sensitive prostate cancer. The independent analysis evaluated how the Decipher test can help identify which patients are most likely to benefit from treatment intensification with triplet therapy (docetaxel to standard of cancer hormonal therapy).
"Together, these studies provide practice-changing evidence supporting the use of Veracyte’s tests in guiding treatment decisions across cancer types," said Phillip Febbo, M.D., Veracyte’s chief scientific and medical officer. "In practice, this means clinicians can more confidently match treatment intensity to individual patient risk, helping ensure the right level of care while avoiding unnecessary treatment and its side effects, for both breast and prostate cancer patients."
Additional research to be presented at ASCO supports the company's mission to transform cancer care for patients all over the world.
Oral Presentations at ASCO 2026 Annual Meeting
Additional Posters at ASCO
For more information, stop by Veracyte’s booth #13069 at the ASCO Annual Meeting or visit the company’s websitehere.
About Veracyte
Veracyte (Nasdaq: VCYT) is a global diagnostics company with a vision to transform cancer care for patients around the world. The company’s molecular tests assess the unique biology of each patient’s tumor to help clinicians answer essential questions about cancer care.Veracyte’s Diagnostics Platformcombines broad genomic and clinical data, advanced bioinformatics and AI, and a powerful evidence-generation engine to support continuedinnovation and pipeline development. The company’s portfolio includes theAfirma® Genomic Sequencing Classifier test,Decipher® Bladder Genomic Classifier test,Decipher® Prostate Genomic Classifier test,Prosigna® Breast Risk of Recurrence test, and theTrueMRD™ Monitoring Test for MIBC. For more information, visit Veracyte’swebsiteor follow the company onLinkedInorX (Twitter).
Cautionary Note Regarding Forward-Looking Statements
This press release contains forward‑looking statements, including, but not limited to, statements regarding the potential clinical utility, impact, and benefits of Veracyte’s Prosigna Breast Risk of Recurrence (ROR) test and Decipher Prostate test; the ability of these tests to guide treatment decisions in both early‑stage breast cancer and metastatic prostate cancer, including identifying patients who may benefit from or avoid certain therapies or treatment intensification; and the extent to which data from the OPTIMA and ENZAMET trials may be considered practice‑changing or influence clinical decision‑making. Forward‑looking statements can be identified by words such as: “appears,” “anticipate,” “intend,” “plan,” “expect,” “believe,” “should,” “may,” “will,” “enable,” “positioned,” “offers,” “designed,” “ultimately,” and similar references to future periods. Actual results may differ materially from those projected or suggested in any forward‑looking statements. These statements involve risks and uncertainties, which could cause actual results to differ materially from our predictions. Additional factors that may impact these forward‑looking statements can be found under the caption “Risk Factors” in our Annual Report on Form 10‑K filed on February 26, 2026 and our subsequent Quarterly Reports on Form 10‑Q. Copies of these documents, when available, may be found in the Investors section of our website athttps://investor.veracyte.com. These forward‑looking statements speak only as of the date hereof and, except as required by law, we specifically disclaim any obligation to update these forward‑looking statements or reasons why actual results might differ, whether as a result of new information, future events or otherwise.