Titan Pharmaceuticals, Inc. FOR IMMEDIATE RELEASE TITAN PHARMACEUTICALS PROVIDES UPDATE ON CONFIRMATORY PHASE 3 STUDY OF PROBUPHINE South San Francisco, CA

TITAN PHARMACEUTICALS PROVIDES UPDATE ON

CONFIRMATORY PHASE 3 STUDY OF

South San Francisco, CA June 17, 2011 Titan Pharmaceuticals, Inc. (TTNP.OB) today announced the

receipt of a letter from the U.S. Food and Drug Administration (FDA) on June 16, 2011, providing comments on the revised Statistical Analysis Plan (SAP) for the confirmatory Phase 3 study of Probuphine for patients with opioid dependence.

Although the data review at all clinical sites is complete and the blinded data set is ready for analysis, Titan will need to delay the analysis of the data briefly to allow time for a discussion with the FDA and subsequent modification of the SAP

We are very pleased with the progress made by the clinical team and the clinical sites in completing the data review at

the beginning of June, and preparing the blinded database for further analysis, said Sunil Bhonsle, president of Titan Pharmaceuticals. We will continue working closely with the FDA to finalize the statistical analysis plan and complete

the analyses expeditiously, although it is unlikely that all this can be completed by the end of June as previously expected. We will provide an update on a revised timeline for reporting results of the study once we have spoken with the Agency in

The Phase 3 clinical trial is a randomized, placebo and active controlled, multi-center study conducted at 20

sites in the U.S. treating approximately 285 patients, aged 18 to 55 years across three dosing arms: Probuphine, Titan s innovative, subcutaneous implant formulation that delivers a steady dose of the marketed drug buprenorphine over six months

following a single treatment; SUBOXONE , the approved and widely-used sublingual formulation of buprenorphine; and placebo. Patients in the trial were treated for 24 weeks and the Probuphine and placebo dosing arms were double-blinded, while the

SUBOXONE arm was open-label. Titan s first placebo controlled Phase 3 clinical trial of Probuphine was completed in 2008 with positive findings published in the Journal of the American Medical Association (JAMA) in October 2010.

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