Full Press Release Details
Positive Early Study
Results Help Pave Wave for Titan Pharmaceuticals to Move Forward with its JT-09 ProNeura Development Program
South San Francisco, CA
- February 1, 2021 - Titan Pharmaceuticals, Inc. (NASDAQ: TTNP) today announced that studies of its kappa opioid agonist
peptide, JT-09, has demonstrated high potency and specificity for the human kappa-opioid receptor ("KOR"). JT-09 is
being developed for use in combination with Titan's ProNeura long-term, continuous drug delivery technology
for the treatment of moderate-to-severe chronic pruritus (itch).
The KOR potency studies
used the cAMP Hunter assay with cloned human mu, delta and kappa opioid receptors. In addition, in studies conducted in
collaboration with Charles Chavkin, Ph.D., Allan and Phyllis Treuer Endowed Chair of Pain Research and Professor, Department of
Pharmacology, at the University of Washington Health Sciences Center, Seattle, WA, pretreatment with JT-09 or with difelikefalin
(which is being developed as Korsuva by Cara Therapeutics, Inc.) were observed to be equally potent in reducing scratching
and grooming bouts when injected subcutaneously (0.3 mg/kg) in a 5'-guanidinonaltrindole (5'-GNTI) itch-induced mouse model.
"Pilot pharmacokinetic
studies in rats previously indicated that subcutaneous placement of ProNeura implants containing JT-09 could deliver potentially
therapeutic concentrations of this KOR agonist for up to six months or longer," said Kate Beebe DeVarney, Ph.D., President
and Chief Operating Officer of Titan.
Dr. Beebe DeVarney continued,
"These additional early positive data provide strong support for us to move forward with our planned non-clinical proof-of-concept
study of JT-09 ProNeura implants in this animal itch model. This is an important next step for Titan towards developing a new treatment
modality for moderate-to-severe chronic pruritus that is effective, patient-friendly and convenient."
About Chronic Pruritus
pruritus is an unpleasant sensation resulting in a need to scratch that lasts more than 6 weeks. It is a prevalent and bothersome
symptom associated with both cutaneous and systemic conditions. Due to its complex pathogenesis and numerous contributing factors,
effective treatment of chronic pruritus therapy remains challenging.
About Titan Pharmaceuticals
Titan Pharmaceuticals,
Inc. (NASDAQ: TTNP) is a development-stage biotechnology company developing proprietary therapeutics using its clinically proven
ProNeura long-term, continuous drug delivery technology. The ProNeura technology has the potential to be used in developing
products for treating a number of chronic conditions where maintaining consistent, around-the-clock blood levels of medication
may benefit the patient and improve medical outcomes. For more information about Titan, please visit www.titanpharm.com.
Forward-Looking Statements
This press release may
contain "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E
of the Securities Exchange Act of 1934. Such statements include, but are not limited to, any statements relating to our product
development programs and any other statements that are not historical facts. Such statements involve risks and uncertainties that
could negatively affect our business, operating results, financial condition and stock price. Factors that could cause actual results
to differ materially from management's current expectations include those risks and uncertainties relating to our ability to raise
capital, the winding down of U.S. commercial activities related to Probuphine, the regulatory approval process, the development,
testing, production and marketing of our drug candidates, patent and intellectual property matters and strategic agreements and
relationships. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking
statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on
which any such statement is based, except as required by law.
Korsuva is a trademark
of Cara Therapeutics, Inc.