Entrada Therapeutics Reports Third Quarter 2021 Financial Results Successful completion of upsized $208.7 million Initial Public Offering

Entrada Therapeutics Reports Third Quarter 2021

Successful completion of upsized $208.7 million

Initial Public Offering

BOSTON, Mass., December 9, 2021 - Entrada Therapeutics, Inc.

(Nasdaq: TRDA), a biopharmaceutical company aiming to transform the lives of patients by establishing intracellular Endosomal Escape Vehicle

(EEV ) therapeutics as a new class of medicines, today reported financial results for the third quarter ended September 30,

2021 and highlighted recent business updates.

"This quarter has been transformational for Entrada as we made

meaningful progress across all areas of our business, including the advancement of our pipeline of EEV therapeutic candidates,"

said Dipal Doshi, President and Chief Executive Officer of Entrada Therapeutics. "The successful close of our upsized initial public

offering in November has placed us in a strong financial position to advance our lead neuromuscular candidate, ENTR-601-44, for patients

with DMD who are exon 44 skipping amenable, through initial clinical data. The financing also enables us to move our second program, an

EEV-PMO for patients with DM1, into clinical development as well as advance additional pipeline assets from our proprietary EEV platform."

In November, Entrada completed an upsized Initial Public Offering (IPO)

raising $208.7 million in gross proceeds. The Company closed its IPO, issuing a total of 10,436,250 shares of Entrada's common stock,

which included the exercise in full by the underwriters of their option to purchase an additional 1,361,250 shares of common stock, at

a public offering price of $20.00 per share. The net proceeds after deducting underwriting discounts, commissions and other estimated

offering expenses were approximately $190.9 million.

Third Quarter 2021 Financial Results

Cash Position: As of September 30, 2021, cash and cash

equivalents were $122.2 million. This amount does not include net proceeds from the November 2021 closing of the Company's

IPO, which raised approximately $190.9 million, after deducting underwriting discounts, commissions and other estimated offering costs.

Research & Development (R&D) Expenses: R&D

expenses for the third quarter of 2021 were $10.5 million as compared to $5.7 million for the same period in 2020. This increase was primarily

due to additional investment in preclinical studies to support future clinical trials, and higher personnel costs (including non-cash

stock-based compensation).

General & Administrative (G&A) Expenses: G&A

expenses for the third quarter of 2021 were $3.9 million as compared to $1.3 million for the same period in 2020. This increase was primarily

due to higher personnel costs (including non-cash stock-based compensation), legal and other professional fees, and facilities costs.

Net Loss: Net loss for the third quarter of 2021 was $14.4 million,

compared to $7.0 million for the third quarter of 2020.

About Entrada Therapeutics

Entrada Therapeutics is a biopharmaceutical company aiming to transform

the lives of patients by establishing a new class of medicines, Endosomal Escape Vehicles (EEV ) therapeutics, to engage intracellular

targets that have long been considered inaccessible and undruggable. The Company's EEV therapeutics are designed to enable the efficient

intracellular delivery of a wide range of therapeutics into a variety of organs and tissues with an improved therapeutic index. Through

its proprietary, highly versatile and modular EEV Platform, Entrada is building a robust development portfolio of oligonucleotide-, antibody-

and enzyme-based programs for the potential treatment of neuromuscular diseases, immunology, oncology and diseases of the central nervous

system. The Company's lead oligonucleotide programs include ENTR-601-44 targeting Duchenne muscular dystrophy (DMD), and a follow-on

program targeting myotonic dystrophy type 1 (DM1).

For more information about Entrada, please visit our website, www.entradatx.com,

Forward-Looking Statements

This press release contains forward-looking statements that involve

substantial risks and uncertainties. All statements, other than statements of historical facts, contained in this press release, including

statements regarding Entrada's strategy, future operations, prospects and plans, objectives of management, the potential of the

EEV platform and the establishment of EEV therapeutics as a new class of medicines, the advancement of ENTR-601-44 through initial clinical

data, the movement of an EEV-PMO candidate for the treatment of DM1 into clinical development, the potential therapeutic benefits of its

EEV candidates and the sufficiency of its cash resources, constitute forward-looking statements within the meaning of The Private Securities

Litigation Reform Act of 1995. The words "anticipate," "believe," "continue," "could,"

"estimate," "expect," "intend," "may," "might," "objective," "ongoing,"

"plan," "predict," "project," "potential," "should," or "would,"

or the negative of these terms, or other comparable terminology are intended to identify forward-looking statements, although not all

forward-looking statements contain these identifying words. Entrada may not actually achieve the plans, intentions or expectations disclosed

in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events

could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various

important factors, including: uncertainties inherent in the identification and development of product candidates, including the conduct

of research activities and the initiation and completion of preclinical studies and clinical trials; uncertainties as to the availability

and timing of results from preclinical studies; the timing of and Entrada's ability to submit and obtain regulatory clearance for

investigational new drug applications and initiate clinical trials; whether results from preclinical studies will be predictive of the

results of later preclinical studies and clinical trials; whether Entrada's cash resources will be sufficient to fund the Company's

foreseeable and unforeseeable operating expenses and capital expenditure requirements; uncertainties associated with the impact of the

COVID-19 pandemic on Entrada's business and operations; as well as the risks and uncertainties identified in Entrada's filings

with the Securities and Exchange Commission (SEC), including the Company's most recent Form 10-Q and in subsequent filings

Entrada may make with the SEC. In addition, the forward-looking statements included in this press release represent Entrada's views

as of the date of this press release. Entrada anticipates that subsequent events and developments will cause its views to change. However,

while Entrada may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation

to do so. These forward-looking statements should not be relied upon as representing Entrada's views as of any date subsequent to

the date of this press release.

ENTRADA THERAPEUTICS, INC.

SELECTED CONDENSED FINANCIAL INFORMATION

(In thousands, except share and per share amounts)

Entrada/Investor Contact

VP, Corporate Communications and Investor Relations