Full Press Release Details
Pharma Announces Antiviral Program Targeting Ongoing Hantavirus and Ebola Virus Disease Outbreaks
antiviral agent with potential utility against Hantavirus, Ebola and Lassa
a novel dual-strike mechanism, the proprietary combination agent has the potential to deliver a low pill burden option to manage existing
and future outbreaks
planned with the US Centers for Disease Control and Prevention (CDC), and ongoing with the Nigerian National Agency for Food and Drug
Administration and Control (NAFDAC), and the African Medicines Agency (AMA) to fast-track clinical development, emergency manufacturing
scale-up, and global access
PA - May 27, 2026 - Traws Pharma, Inc. (NASDAQ: TRAW), a clinical-stage biopharmaceutical company developing
novel therapies for critical global viral threats, today announced the advancement of a novel proprietary broad-spectrum combination
anti-viral agent in its portfolio. The investigational combination utilizes a unique "dual-strike" mechanism of action that
hijacks host cell pathways to force viral eradication. Importantly, both components of the combination have been safely evaluated in
human studies as single agents.
rely entirely on cellular infrastructure to replicate and are dependent on the host cell's internal nucleotide pools. Traws Pharma's
novel combination therapy exploits this dependency through a coordinated, synergistic approach:
aggressively reducing the intracellular competition between natural nucleotides and the active drug, this mechanism drastically lowers
the effective concentration (IC90) of the nucleoside prodrug required to completely halt replication. This maximizes the therapeutic
potency against Hantavirus (Bunyavirus) Ebola (Filovirus) and Lassa (Arenavirus), while minimizing potential toxicity and achieving high
efficacy at lower doses," commented C. David Pauza, PhD, Chief Science Officer of Traws Pharma.
Company is advancing non-clinical development and evaluating the therapeutic combination in validated animal models of Hantavirus and
Ebola. The critical studies will be conducted within Biosafety Level 3 (BSL-3) and Biosafety Level 4 (BSL-4) Laboratories.
ensure rapid response capabilities, given the ongoing outbreaks of Hantavirus and Ebola, Traws Pharma is concurrently scaling up its
chemical development and manufacturing infrastructure to enable an immediate supply of the therapeutic combination to appropriate health
agencies for immediate use and potential stockpiling," commented Iain Dukes, MA, DPhil, Chief Executive Officer of Traws Pharma.
the critical importance of regional healthcare organizations and rapid deployment, Traws Pharma will build on existing contacts in Nigeria,
in particular its relationship with the NAFDAC to develop sustainable, local manufacturing of drug products. This strategic alignment
aims to streamline regulatory pathways and ensure equitable, rapid access to life-saving therapeutics across the African continent.
pairing a powerful host-targeted mechanism with nucleotide antivirals, we are presenting a formidable barrier to viral replication and
resistance," said Robert R. Redfield, MD Chief Medical Officer of Traws Pharma and former Head of the CDC. "Our developing
cooperation with NAFDAC and AMA Medical Manufacturing should ensure that as we finalize our data and scale production, we are fully prepared
to transition from the lab straight to the frontlines of global public health and potential stockpiling. We look forward to expanding
our interactions with the appropriate regional health agencies, including the CDC."
Pharma is a clinical-stage biopharmaceutical company dedicated to developing novel therapies to target critical threats to human health
in respiratory viral diseases. Traws integrates antiviral drug development, medical intelligence and regulatory strategy to meet real
world challenges in the treatment of viral diseases. We are advancing novel investigational oral small molecule antiviral agents that
have potent activity against difficult to treat or resistant virus strains that threaten human health including seasonal influenza and
H5N1 bird flu, negative-strand RNA viruses including Hantavirus, Ebola Virus Disease, Lassa Fever and COVID-19/Long COVID. Lead program,
tivoxavir marboxil, is in development as a once-monthly oral prophylactic agent for influenza prevention, with additional potential as
a single-dose therapy for seasonal flu or H5N1 bird flu, targeting the influenza cap-dependent endonuclease (CEN).
of the statements in this release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933,
as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation Reform Act of
1995, and involve risks and uncertainties including statements regarding the Company, its business and product candidates, including
the potential opportunity, market size, benefits, effectiveness, safety, and the clinical and regulatory plans for tivoxavir marboxil
and ratutrelvir and other investigational antiviral agents, as well as plans for its legacy programs. The Company has attempted to identify
forward-looking statements by terminology including "believes", "estimates", "anticipates", "expects",
"plans", "intends", "may", "could", "might", "will", "should",
"preliminary", "encouraging", "approximately" or other words that convey uncertainty of future events
or outcomes. Although Traws believes that the expectations reflected in such forward-looking statements are reasonable as of the date
made, expectations may prove to have been materially different from the results expressed or implied by such forward looking statements.
These statements are only predictions and involve known and unknown risks, uncertainties, and other factors, including the outcome of
Traws' IND filing with the FDA for tivoxavir marboxil, including the current FDA clinical hold; the success and timing of Traws'
clinical trials; Traws' ability to identify and advance potential clinical candidates for the treatment of Hantavirus infections,
Ebola Virus Disease, Lassa Fever, the potential efficacy of ratutrelvir for the treatment of COVID-19, including the potential to reduce
the risk of COVID rebound and Long COVID; the potential for tivoxavir marboxil and ratutrelvir and other investigational antiviral agents
to gain market acceptance, if and when regulatory approval is obtained, or to become the new standard of care; Traws' interactions
with the FDA, BARDA, CDC, NAFDAC, AMA and similar foreign regulators; collaborations; market conditions; regulatory requirements and
pathways for approval; the ongoing need for improved therapy to reduce the frequency of clinical rebound and the concomitant risk for
Long COVID; the extent of the spread and threat of pandemic flu including H5N1 bird flu; the Company's cash projections; Traws'
ability to raise additional capital when needed; and those discussed under the heading "Risk Factors" in Traws' filings
with the U.S. Securities and Exchange Commission (SEC). Any forward-looking statements contained in this release speak only as of its
date. Traws undertakes no obligation to update any forward-looking statements contained in this release to reflect events or circumstances
occurring after its date or to reflect the occurrence of unanticipated events, except to the extent required by law.
LifeSci Advisors, LLC