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Onconova Therapeutics Regains Compliance with Nasdaq Continued Listing Requirement NEWTOWN, Pa.

Key Takeaway: Therapeutics Regains Compliance with Nasdaq Continued Pa., February 24, 2021 (GLOBE NEWSWIRE) - Onconova Therapeutics, Inc. (NASDAQ: ONTX) ("Onconova"), a biopharmaceutical company focused on discovering and developing novel products for patients with cancer, announces receipt

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Therapeutics Regains Compliance with Nasdaq Continued
Pa., February 24, 2021 (GLOBE NEWSWIRE) - Onconova Therapeutics, Inc. (NASDAQ: ONTX) ("Onconova"), a biopharmaceutical
company focused on discovering and developing novel products for patients with cancer, announces receipt of notification from
Nasdaq that the Company has regained compliance with the minimum bid price requirement of Nasdaq Listing Rule 5550(a)(2) because
the Company's common stock had a closing price of at least $1.00 per share for a minimum 10 consecutive business days. As
previously reported, the Company was granted until April 5, 2021 to meet this requirement.
M.D., President and Chief Executive Officer of Onconova Therapeutics, said, "We are pleased that we have regained compliance
with Nasdaq's minimum bid requirement for continued listing of our stock. We appreciate the investor support and confidence
we have seen recently. 2021 will continue to be a decisive year for Onconova as ON 123300 enters the clinic in the U.S. in a Phase
1 trial, and we are on target to initiate this trial in patients with advanced cancer in the next few months."
Onconova Therapeutics, Inc.
Therapeutics is a biopharmaceutical company focused on discovering and developing novel products to treat cancer. The Company
has proprietary targeted anti-cancer agents designed to disrupt specific cellular pathways that are important for cancer cell
novel, proprietary multi-kinase inhibitor ON 123300 is planned to begin a dose-escalation and expansion Phase 1 trial in the U.S.
in the first half of 2021, and a dose-escalation and expansion Phase 1 trial is currently underway in China. Onconova's
product candidate oral rigosertib is currently in a dose-escalation and expansion Phase 1 investigator-initiated study targeting
patients with KRAS+ lung adenocarcinoma in combination with nivolumab. In addition, Onconova has commenced preclinical work investigating
rigosertib in COVID-19. For more information, please visit www.onconova.com.
the statements in this release are forward-looking statements within the meaning of Section 27A of the Securities Act of
1933, as amended, Section 21E of the Securities Exchange Act of 1934, as amended, and the Private Securities Litigation
Reform Act of 1995, and involve risks and uncertainties. These statements relate to Onconova's expectations regarding
the registered direct offering, its patents and clinical development plans including [patient enrollment timelines and]
indications for its product candidates. Onconova has attempted to identify forward-looking statements by terminology
including "believes," "estimates," "anticipates," "expects," "plans,"
"intends," "may," "could," "might," "will," "should,"
"approximately" or other words that convey uncertainty of future events or outcomes. Although Onconova believes
that the expectations reflected in such forward-looking statements are reasonable as of the date made, expectations may prove
to have been materially different from the results expressed or implied by such forward-looking statements. These statements
are only predictions and involve known and unknown risks, uncertainties, and other factors, including the success and timing
of Onconova's clinical trials and regulatory agency and institutional review board approvals of protocols, Onconova's
ability to continue as a going concern, the need for additional financing, Onconova's collaborations, market conditions
and those discussed under the heading "Risk Factors" in Onconova's most recent Annual Report on Form 10-K and
quarterly reports on Form 10-Q. Any forward-looking statements contained in this release speak only as of its date. Onconova
undertakes no obligation to update any forward-looking statements contained in this release to reflect events or
circumstances occurring after its date or to reflect the occurrence of unanticipated events.
Last updated: Feb 24, 2021