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Tempest Announces Amezalpat Poster Presentation at the 2025 American Association for Cancer Research (AACR) Annual Meeting

Key Takeaway: Tempest Therapeutics announced that an abstract on amezalpat, a PPARα antagonist, has been accepted for poster presentation at the 2025 AACR Annual Meeting. The presentation will focus on the immune component of amezalpat's mechanism of action. Scheduled for April 28, 2025, the session aims to explore the interplay between the immune system and cancer therapies. This opportunity showcases Tempest's ongoing contributions to cancer treatment research and development.
Price reaction · baseline $5.3625 (2025-03-24 close) · hit after-hours · 1 other TPST headline(s) in the window, move may be shared
day 0 close · peak
-0.2%

Market Sentiment Analysis

POSITIVE FACTORS

  • Amezalpat's data supporting its immune component was accepted for presentation.
  • The poster presentation at a significant conference like AACR increases visibility and credibility.
  • The research highlights novel mechanisms that could have a substantial impact on cancer therapy.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+41%
120-day peak, hindsight
Typical move
10.6%
average across 2 past catalysts
Cash runway
~1 mo
High dilution risk
Lead asset
ATR-101
Phase 2 · Congenital Adrenal Hyperplasia

Full Press Release Details

BRISBANE, Calif., March 25, 2025 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (Nasdaq: TPST), a clinical-stage biotechnology company developing first-in-classi targeted and immune-mediated therapeutics to fight cancer, today announced that an abstract highlighting data supporting the immune component of amezalpat’s purported mechanism of action has been accepted for poster presentation at the 2025 American Association for Cancer Research (AACR) Annual Meeting taking place April 25-30, 2025 in Chicago, IL.
Poster presentation details:
Title: Amezalpat, a peroxisome proliferator-activated receptor alpha (PPARα) antagonist, inhibits suppressive macrophage development, activation and function
Abstract Number: 2171
Date & Time: Monday, April 28, 2025, 9:00 a.m. – 12:00 p.m. CT
Session Category: Immunology
Session Title: Interplay between Immune System and Radio-, Chemo- and Targeted Therapies 1
Location: Poster Section 35
All regular abstracts are available for viewing via AACR’s online itinerary planner located, here.
About Tempest Therapeutics
Tempest Therapeutics is a clinical-stage biotechnology company advancing a diverse portfolio of small molecule product candidates containing tumor-targeted and/or immune-mediated mechanisms with the potential to treat a wide range of tumors. The company’s novel programs range from early research to later-stage investigation in a randomized global study in first-line cancer patients. Tempest is headquartered in Brisbane, California. More information about Tempest can be found on the company’s website at www.tempesttx.com.
Forward-Looking Statements
This press release contains forward-looking statements (including within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and Section 27A of the Securities Act of 1933, as amended (the “Securities Act”)) concerning Tempest Therapeutics, Inc. These statements may discuss goals, intentions, and expectations as to future plans, trends, events, results of operations or financial condition, or otherwise, based on current beliefs of the management of Tempest Therapeutics, as well as assumptions made by, and information currently available to, management of Tempest Therapeutics. Forward-looking statements generally include statements that are predictive in nature and depend upon or refer to future events or conditions, and include words such as “may,” “will,” “should,” “would,” “could”, “expect,” “anticipate,” “plan,” “likely,” “believe,” “estimate,” “project,” “intend,” and other similar expressions. All statements that are not historical facts are forward-looking statements, including any statements regarding: the design, initiation, progress, timing, scope and results of clinical trials, including the anticipated Phase 3 study for amezalpat; anticipated therapeutic benefit and regulatory development of the Company’s product candidates the Company’s ability to advance into a late-stage clinical company; and the Company’s ability to achieve its operational plans. Forward-looking statements are based on information available to Tempest Therapeutics as of the date hereof and are not guarantees of future performance. Any factors may cause differences between current expectations and actual results, including: unexpected safety or efficacy data observed during preclinical or clinical trials; clinical trial site activation or enrollment rates that are lower than expected; changes in expected or existing competition; changes in the regulatory environment; and unexpected litigation or other disputes. Other factors that may cause actual results to differ from those expressed or implied are discussed in greater detail in the “Risk Factors” section of the Company’s Quarterly Report on Form 10-Q filed for the quarter ended September 30, 2024 and other documents filed by the Company from time to time with the Securities and Exchange Commission. Except as required by applicable law, Tempest Therapeutics undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise. These forward-looking statements should not be relied upon as representing Tempest Therapeutics’ views as of any date subsequent to the date of this press release and should not be relied upon as prediction of future events. In light of the foregoing, investors are urged not to rely on any forward-looking statement in reaching any conclusion or making any investment decision about any securities of Tempest Therapeutics.
Investor & Media Contacts:
Wheelhouse Life Science Advisors
Wheelhouse Life Science Advisors
i If approved by the FDA

Frequently Asked Questions

What is the focus of Tempest Therapeutics?

Tempest Therapeutics develops first-in-class targeted and immune-mediated cancer therapeutics.

Where will the poster presentation for amezalpat take place?

The poster presentation will occur at the AACR Annual Meeting in Chicago, IL.

What is the title of Tempest's abstract on amezalpat?

The title is 'Amezalpat, a PPARα antagonist, inhibits suppressive macrophage development.'

When and where is the amezalpat poster presentation scheduled?

It is scheduled for April 28, 2025, from 9:00 a.m. to 12:00 p.m. CT.

What is the main mechanism of action for amezalpat?

Amezalpat acts as a PPARα antagonist, affecting macrophage function.

Last updated: Mar 25, 2025