2017 Tonix Pharmaceuticals Holding Corp.

2017 Tonix Pharmaceuticals Holding Corp. Presented by Gregory Sullivan, MD at American Society of Clinical Psychopharmacology Annual Meeting, Miami, FL May 30, 2017 Bedtime Sublingual Transmucosal Cyclobenzaprine (TNX - 102 SL) for the Treatment of Military - Related PTSD: Retrospective Analyses of the Mediators and Moderators of Treatment Response

2017 Tonix Pharmaceuticals Holding Corp. 2 What is Military - Related PTSD and Why Study It? Proposed indication for TNX - 102 SL* is for the treatment of posttraumatic stress disorder (PTSD): Affects 8.6 million U.S. adults 1 Definition of military - related PTSD: Any PTSD that has developed in response to any DSM - 5 PTSD Criterion A - qualifying trauma(s) that occurred during military service - includes combat and non - combat traumas Why target military - related PTSD? No treatment response observed in U.S. military population with the two FDA - approved selective serotonin reuptake inhibitors (SSRIs) for PTSD 2,3,4 No other type of pharmacological treatment had been shown to be effective in any large multicenter clinical trial in a U.S. military population 1 Kessler et al., Arch Gen Psych 2005; Prevalence rate of 3.5% applied to U.S. Census estimate of 247M U.S. adult ( > 18) population in 2015; 2 Friedman MJ et al. J Clin Psychiatry 2007;68:711 - 20. 3 Zoloft Package Insert, Pfizer, NY, NY; August 2014. 4 Paxil Package Insert, Glaxo, June 2014; ( www.census.gov/quickfacts/table/PST045215/00 ) ; *T NX - 102 SL (cyclobenzaprine HCl sublingual tablets) is an investigational new drug and is not approved for any indication.

2017 Tonix Pharmaceuticals Holding Corp. 3 What is TNX - 102 SL? TNX - 102 SL is a patented 1 sublingual eutectic formulation of cyclobenzaprine (CBP) for transmucosal absorption Tricyclic molecule with high affinity for target receptors considered to play key roles in sleep physiology and nocturnal emotional memory processing F unctional studies show antagonism at each of 2 5 - HT 2A a 1 - adrenergic Histamine - H 1 No recognized risk of addiction TNX - 102 SL is designed for bedtime administration with desirable nighttime pharmacokinetic profile and pharmacodynamics effects Rapid systemic exposure and increased bioavailability during sleep period Avoids first - pass metabolism reducing exposure to long - lived active metabolite, norcyclobenzaprine ( nCBP ) t 1/2 ~72 hours Less selective for target receptors - > undesirable off - target functional activities Exposure ( AUC 0 - 48 ) for CBP/ nCBP of 1.9 for TNX - 102 SL vs. 1.2 for oral IR tablet 2 TNX - 102 SL has been designated a Breakthrough Therapy for PTSD by the U.S. Food and Drug Administration (FDA) 1 Notice of Allowance for Eutectic Proprietary Protectic Formulation Patent issued by the U.S. Patent and Trademark Office; 2 Daugherty et al. Society of Biological Psychiatry 70 th Annual Scientific Convention, May 14 - 16, 2015 Toronto, Ontario, Canada. 3 Lederman et al. European Congress of Rheumatology, Rome, June 2015; IR, immediate - release

2017 Tonix Pharmaceuticals Holding Corp. 4 Rationale for Targeting of Sleep for Treatment of PTSD PTSD is a disorder of recovery Most people exposed to an extreme trauma recover in a few weeks New learning, e.g. extinction, and memory processing are essential to recovery In PTSD, memory processing, e.g. extinction consolidation, 1,2 may be impeded due to insufficient sleep quality TNX - 102 SL targets sleep quality Potent binding and antagonism at receptors that regulate sleep quality 3 , e.g. 5 - HT 2A , a 1 - adrenergic, and histamine H 1 receptors, during the sleep period is hypothesized to be permissive to sleep quality - dependent recovery processes from trauma and PTSD 1 Pace - Schott et al. Biol Mood Anxiety Disord 2015;5:3. 2 Menz et al. J Neurosci 2016;36(7):2148. 3 Daugherty et al., Abstract 728, Society of Biological Psychiatry 70th Annual Scientific Convention, May 14 - 16, 2015,Toronto Ontario, Canada

2017 Tonix Pharmaceuticals Holding Corp. 5 Phase 2 AtEase Study in Military - Related PTSD Randomized, double - blind, placebo - controlled trial in military - related PTSD Efficacy analysis from 231 patients; 24 U.S. clinical sites Enrolled patients with baseline CAPS - 5 score 29 Primary Efficacy Analysis: Difference in CAPS - 5 score change from baseline between TNX - 102 SL 2.8 mg and placebo at week 12 Key Secondary Measures: PROMIS Sleep Disturbance, CGI - I, SDS TNX - 102 SL at bedtime once - daily Placebo at bedtime once - daily 12 weeks N= 90 TNX - 102 SL at bedtime once - daily N= 92 N= 49 2.8 mg 5.6 mg (2 x 2.8 mg) CAPS - 5, Clinician - Administered PTSD Scale for DSM - 5

2017 Tonix Pharmaceuticals Holding Corp. 6 AtEase Study Results: Primary and Sensitivity Analyses of CAPS - 5 Change from Baseline TNX - 102 SL 2.8 mg dose (N=90) had a greater CAPS - 5 change from baseline at Week 2 (MMRM, p=0.040) and Week 4 (MMRM, p=0.030) but did not achieve a significantly greater CAPS - 5 change from baseline at Week 12 (MMRM, p=0.259, NS) compared with placebo (N=92) TNX - 102 SL 5.6 mg dose (N=49) had a strong trend (MMRM, p=0.053) for greater CAPS - 5 change from baseline at Week 12 compared with placebo (N=92); Effect size of 0.36 (Cohen's d ) Pre - planned sensitivity analyses that accounted for missing data, as well as ANCOVA, showed statistically significant results for TNX - 102 SL 5.6 mg v. placebo: MMRM with multiple imputation p=0.031 MMRM with hybrid LOCF/BOCF imputation p=0.037 ANCOVA p=0.038 ANCOVA, analysis of covariance; BOCF, baseline observation carried forward; CAPS - 5, Clinician - Administered PTSD Scale for DSM - 5; LOCF, last observation carried forward; MMRM, mixed - effect model repeated measures; N, number; NS, not significant

2017 Tonix Pharmaceuticals Holding Corp. 7 AtEase Study Results: Primary Endpoint CAPS - 5 Total Score by MMRM with MI -25 -20 -15 -10 -5 0 Wk 0 Wk 2 Wk 4 Wk 6 Wk 8 Wk 10 Wk 12 Placebo TNX-102 SL 2.8 mg TNX-102 SL 5.6 mg * * p=0.031, comparing placebo and TNX - 102 SL 5.6 mg, * p<0.05, comparing placebo and TNX - 102 SL 2.8 mg, by MMRM with MI, mixed - effect model repeated measures with multiple imputation; CAPS - 5, Clinician Administered PTSD Scale for DSM - 5; LS Mean, least squares mean * * CAPS - 5 LS Total Score Mean Change from Baseline 5.0 point difference in CAPS - 5 change from baseline between placebo and TNX - 102 SL 5.6 mg LS Mean Change from Baseline

2017 Tonix Pharmaceuticals Holding Corp. 8 AtEase Study Results: Safety and Tolerability Trial Completion Rates: 73% Placebo; 79% TNX - 102 SL 2.8 mg; 84% TNX - 102 SL 5.6 mg Systemic adverse events (AEs) and local administration site reactions occurring at 5% rate in either TNX - 102 SL group: Placebo TNX - 102 SL 2.8 mg TNX - 102 SL 5.6 mg Systemic Adverse Events (N=94)* (N=93)* (N=50)* Somnolence 6.4% 11.8% 16.0% Dry Mouth 10.6% 4.3% 16.0% Headache 4.3% 5.4% 12.0% Insomnia 8.5% 7.5% 6.0% Sedation 1.1% 2.2% 12.0% Local Administration Site Reactions Hypoaesthesia oral # 2.1% 38.7% 36.0% Paraesthesia 3.2% 16.1% 4.0% Glossodynia 1.1% 3.2% 6.0% # Oral hypoaesthesia (tongue numbness) was most common AE, generally transient (<60 minutes), non - dose related and rated mild in 89% and moderate in 11% on TNX - 102 SL; *Safety Population (N=237)

2017 Tonix Pharmaceuticals Holding Corp. 9 Sleep as a Mediator of PTSD Treatment Response Mechanism of action of TNX - 102 SL is hypothesized to be through improvement in sleep quality Sleep responded early in treatment with TNX - 102 SL, by Week 2 on CAPS - 5 sleep disturbance (SD) item PROMIS SD instrument administered on Weeks 4, 8 and 12 In a post hoc analysis, examined the relationship between early response on sleep by PROMIS SD at Week 4 and change in severity of PTSD by the Week 12 endpoint in the three treatment groups (next slide) For change in severity, used CAPS - 5 total change from baseline without the sleep item (E6) to avoid co - linearity effects between the two variables

2017 Tonix Pharmaceuticals Holding Corp. 10 Sleep as Mediator of PTSD Treatment Response Week 4 Sleep Change by PROMIS SD v. Week 12 CAPS - 5 Response* -50 -40 -30 -20 -10 0 10 20 -40 -30 -20 -10 0 10 20 30 CFB in Total CAP - 5 (minus E6) at Week 12 CFB in PROMIS Sleep Disturbance T - Score at Week 4 Placebo p=0.967 TNX - 102 SL 2.8 mg p=0.069 TNX - 102 SL 5.6 mg p=0.015 TNX - 102 SL Pooled p=0.003 *CAPS - 5 without sleep item (E6) CFB, change from baseline

2017 Tonix Pharmaceuticals Holding Corp. 11 Summary of Hypothesized Mechanism of Action in PTSD Recovery (over weeks) Diagram adapted from Pace - Schott et al. Biol Mood Anxiety Disord 2015;5:3 Recovery is a learning process, e.g. depends on extinction learning Extinction learning occurs in the daytime Consolidation (STM - >LTM) of extinction occurs during sleep; roles for both REM and SWS Restoring quality of critical sleep stages may be permissive to consolidation of extinction memory and thereby allow normal recovery LTM, long term memory; STM, short term memory; REM, rapid eye movement; SWS, slow wave sleep Recovery in PTSD Resulting from Treatment with TNX - 102 SL is Mediated by Improvement in Sleep Quality

2017 Tonix Pharmaceuticals Holding Corp. 12 Assessing CAPS - 5 Entry Threshold in AtEase Score of 29 on CAPS - 5 (20 items) required at screening & baseline >50 on prior versions of CAPS (17 items) typical in previous drug registration trials Extrapolation from prior versions of CAPS: ((50/17 items)/2) x 20 items = 29.4 Post - hoc analysis to impute CAPS for DSM - IV ( iCAPS - IV) scores for each subject Baseline iCAPS - IV score calculated by summing 17 items in common with CAPS - 5 and multiplying by two (for 0 - 8 intensity + frequency rather than 0 - 4) 4.3% of the sample had baseline iCAPS - IV of 50 Choosing CAPS - 5 33 results in all iCAPS - IV > 50 80% of mITT had baseline CAPS - 5 of 33 Primary analysis of AtEase was run for subgroup with baseline CAPS - 5 33

2017 Tonix Pharmaceuticals Holding Corp. 13 0.53 0.46 0.012 0.39 0.52 0 0.1 0.2 0.3 0.4 0.5 0.6 Effect Size AtEase Retrospective Analysis: Effect Sizes for Total CAPS - 5 and Cluster Scores * MMRM, mixed - effects model repeated measures, p<0.05 Effect sizes calculated for total CAPS - 5 and clusters for patients with entry CAPS - 5 33 Larger effect size, in moderate range of 0.5, for total CAPS - 5 and intrusion and hyperarousal clusters * * * Based on findings of post - hoc imputed CAPS, a baseline CAPS - 5 score 33 was set as PTSD severity inclusion criterion in Phase 3 trial 7.2 points ** p<0.01, * p<0.025, TNX - 102 SL 5.6 group with placebo, MMRM with multiple imputation (MI); * p=0.018, TNX - 102 SL 2.8 mg group with placebo, MMRM with MI Effect Sizes in Subgroup with 33 CAPS - 5 Entry Score CAPS - 5 Change in Subgroup with 33 CAPS - 5 Entry Score

2017 Tonix Pharmaceuticals Holding Corp. 14 AtEase Study Retrospective Analysis: Remission from PTSD (CAPS - 5 Baseline 33 Subgroup) Asterisks and hashmark represent pairwise comparisons, TNX - 102 SL group v. placebo, logistic regression * p<0.05; # p=0.060 Optimal outcome of treatment is achievement of remission, a virtually asymptomatic state Definition of remission used in AtEase was " Loss of Diagnosis and Endpoint CAPS - 5 Score <11 " By Week 8, significantly more remitters in both 2.8 mg and 5.6 mg groups By week 12: 5.6 mg group trended for higher rate than placebo (rates increased in both groups) 3.9% 7.8% 9.1% 14.3% 10.0% 11.4% 22.9% 17.1% 2.6% 13.2% 23.7% 28.9% 0% 5% 10% 15% 20% 25% 30% 35% 40% Week 2 Week 4 Week 8 Week 12 Percent of Participants in Remission Placebo (N=77) TNX-102 SL 2.8 mg (N=70) TNX-102 SL 5.6 mg (N=38) # * *

2017 Tonix Pharmaceuticals Holding Corp. 15 AtEase Study Retrospective Analysis: Sustained Remission in CAPS - 5 Baseline 33 Subgroup 5.20% 14.30% 21.10% 0% 5% 10% 15% 20% 25% 30% Weeks 8 & 12 Percent in Remission Placebo (N=77) TNX-102 SL 2.8 mg (N=70) TNX-102 SL 5.6 mg (N=38) # * Remission = Loss of Diagnosis and CAPS - 5 < 11 Asterisk and hashmark represent pairwise comparisons between TNX - 102 SL and Placebo; # p=0.08, Odds Ratio 3.01 (0.89, 10.18) *p=0.02, Odds Ratio 4.60 (1.27, 16.66); logistic regression Remission is more clinically meaningful if it is sustained In order to look at sustained remission in AtEase : Determined rates of participants who met remission status at both Week 8 and Week 12 21% of the TNX - 102 SL 5.6 mg participants met for sustained remission v. 5% of placebo (p=0.02) In Phase 3, open label extension study of TNX - 102 SL 5.6 mg will allow a look at sustained remission beyond Week 12

2017 Tonix Pharmaceuticals Holding Corp. 16 Phase 3 HONOR Study in PTSD Enrolling General s tudy c haracteristics: Randomized, double - blind, placebo - controlled, entrance CAPS - 5 33 One unblinded interim analys i s (IA) by an independent data monitoring committee at 50% randomized IA (N ~ 275 ) for efficacy stop , continuation as planned or sample size adjustment Potential to enroll 550 patients Approximately 3 5 U.S. clinical sites Primary e fficacy e ndpoint: Mean change from baseline in total CAPS - 5 at Week 12 compared between TNX - 102 SL 5.6 mg and placebo Placebo once - daily at bedtime 12 weeks TNX - 102 SL once - daily at bedtime N ~ 275 (140*) N ~ 275 (140*) 5.6 mg 1H 2018 - IA outcome anticipated 2H 2018 - topline data anticipated, if 550 patients are studied To confirm Phase 2 AtEase findings in military - related PTSD: Larger adaptive design study Enrollment started in 1Q 2017 * Interim analysis open - label extension

2017 Tonix Pharmaceuticals Holding Corp. 17 Conclusions Phase 2 clinical investigation established that TNX - 102 SL 5.6 mg is the potential efficacious and safe dose to treat PTSD in a military - related PTSD population (TNX - 102 SL 5.6 mg, N=49 v. placebo, N=92) Established CAPS - 5 33 as entry threshold for Phase 3 studies to confirm AtEase findings Relationship between early sleep improvement and Week 12 PTSD recovery supports mechanistic hypothesis that improved sleep quality is a mediator of TNX - 102 SL treatment response TNX - 102 SL 5.6 mg treatment resulted in sustained remission between Weeks 8 and 12 in 21% of participants that was statistically significant relative to placebo and approximately 4X the rate in placebo in the CAPS - 5 33 subgroup (TNX - 102 SL, N=38 v. placebo, N=77) Phase 3 clinical investigation of TNX - 102 SL 5.6 mg in military - related PTSD is ongoing

2017 Tonix Pharmaceuticals Holding Corp. Thank you ! NASDAQ: TNXP