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Phase II OPALESCENCE Study of TLX250-CDx in Triple Negative Breast Cancer to be Presented at SABCS

Key Takeaway: Telix has announced that the Phase II OPALESCENCE study of TLX250-CDx will be presented at the 2023 San Antonio Breast Cancer Symposium. The study aims to evaluate CAIX-targeted PET imaging for diagnosing and staging triple-negative breast cancer. Dr. Caroline Rousseau will present the top-line results on December 6, highlighting the potential of CAIX as a therapeutic target.

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POSITIVE FACTORS

  • Presentation of promising Phase II study results.
  • Focus on a significant unmet medical need in TNBC.
  • Potential for CAIX-targeted imaging to improve diagnosis.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+13%
120-day peak, hindsight
Typical move
7%
average across 7 past catalysts
Lead asset
131I-IPA
Phase 1 · Neoplastic Disease

Full Press Release Details

Melbourne (Australia) | 30 November 2023
Telix today advises that the completed Phase II OPALESCENCE investigator-initiated trial (IIT) of its carbonic anhydrase IX (CAIX)-targeting positron emission tomography (PET) imaging candidate, TLX250-CDx ( 89 Zr-DFO-girentuximab), in patients with triple-negative breast cancer (TNBC), will be presented at the 2023 San Antonio Breast Cancer Symposium ® (SABCS) taking place from December 5-9, 2023.
Dr. Caroline Rousseau, Principal Investigator for the OPALESCENCE study (ClinicalTrials.gov ID NCT04758780 ) at the Institut de Cancérologie de l’Ouest (ICO) in St Herblain (France), will deliver top-line results as a poster presentation at 5pm CT on Wednesday December 6.
The primary objective of the OPALESCENCE study was to evaluate how CAIX-targeted imaging with PET can be utilised for the diagnosis and staging of TNBC and to develop a deeper understanding of CAIX as a potential therapeutic target in this patient population with a significant unmet medical need.
SABCS is the largest and most prestigious scientific gathering on breast cancer research worldwide. Visit http://www.sabcs.org/ for more information on the congress.
Read the full media release here

Frequently Asked Questions

What is the OPALESCENCE study about?

The OPALESCENCE study evaluates CAIX-targeted PET imaging for diagnosing triple-negative breast cancer.

When will the study results be presented?

The results will be presented on December 6, 2023, at the SABCS.

Who is the principal investigator of the study?

Dr. Caroline Rousseau is the principal investigator for the OPALESCENCE study.

What is the significance of the SABCS?

SABCS is the largest scientific gathering focused on breast cancer research globally.

Last updated: Nov 29, 2023