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Expert Forum on PSMA-targeting Radiopharmaceuticals including ProstACT Therapy Program of First-in-Class rADC, TLX591

Key Takeaway: An expert forum moderated by Dr. Colin Hayward discussed the advancements in PSMA-targeted radiopharmaceuticals, particularly focusing on Telix's investigational drug TLX591. The forum highlighted the ProstACT GLOBAL study and recent findings from the ProstACT SELECT study, showcasing the potential benefits of this antibody-based therapy. Key opinion leaders in prostate cancer provided insights into the evolving treatment landscape.

Market Sentiment Analysis

POSITIVE FACTORS

  • Expert discussion on innovative PSMA-targeted therapies.
  • Highlighting promising data from ProstACT SELECT study.
  • Involvement of leading experts in prostate cancer treatment.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+13%
120-day peak, hindsight
Typical move
7%
average across 7 past catalysts
Lead asset
131I-IPA
Phase 1 · Neoplastic Disease

Full Press Release Details

Melbourne (Australia) | 21 November 2023
Telix Group Chief Medical Officer, Dr Colin Hayward, moderated an expert discussion with global key opinion leaders on the evolving treatment landscape for PSMA-targeted radiopharmaceuticals, including Telix’s first-in-class investigational radio-antibody drug conjugate (rADC), TLX591 ( 177 Lu-rosopatamab tetraxetan).
Topics included ProstACT GLOBAL study design (ClinicalTrials.gov ID: NCT04876651 ), and recent data from Telix’s ProstACT SELECT study (ClinicalTrials.gov ID: NCT04786847 ) which reinforces the potential benefits of the antibody-based approach.

Key Opinion Leaders

Scott T. Tagawa
Scott T. Tagawa, MD, is a New York-based Professor of Medicine and Urology. Dr Tagawa’s research focuses on clinical and translational investigations in genitourinary tumours and thrombosis in malignancy. Additionally, he specialises in drug development and theranostics in prostate cancer. He was co-PI of the VISION trial (ClinicalTrials.gov ID: NCT03511664 ), an international Phase III study of 177 Lu-PSMA in advanced prostate cancer and is a Fellow of the American Society of Clinical Oncology (ASCO).
Oliver Sartor
Oliver Sartor, MD, is an internationally recognised expert in prostate cancer. His medical practice and research have focused on prostate cancer since 1990 when he finished a medical oncology fellowship at the National Cancer Institute (NCI). He has published over 400 peer-reviewed articles, led or co-led multiple national and international clinical studies, including three Phase III studies pivotal for FDA approval. He was also co-PI of the VISION trial.
Nat Lenzo
Nat Lenzo, MD, is an adjunct clinical professor in Medicine at Curtin University and Notre Dame University Australia. He also works as a consultant nuclear physician and acute medicine physician at Fiona Stanley Hospital, and general physician at St John of God Hospital Murdoch. With a track record in developing clinical and research services in both the public and private sectors, Dr Lenzo has an interest in oncology and theranostics. He is the co-investigator on a number of grants, a principal investigator in several clinical trials, and a co-author on many peer-reviewed publications.

Frequently Asked Questions

What is TLX591?

TLX591 is a first-in-class investigational radio-antibody drug conjugate targeting PSMA.

What studies were discussed at the forum?

The forum discussed the ProstACT GLOBAL and ProstACT SELECT studies.

Who moderated the expert discussion?

Dr. Colin Hayward, Chief Medical Officer of Telix Group, moderated the discussion.

What is the focus of the ProstACT studies?

The ProstACT studies focus on the potential benefits of antibody-based therapies in prostate cancer.

Last updated: Nov 21, 2023