Full Press Release Details
Tiziana Life Sciences to Participate in BIO-Europe
2024 to Discuss Recent Clinical Advancements, Including Positive GLP-1 Combination Study Data
NEW YORK, November 1, 2024 - Tiziana Life Sciences, Ltd. (Nasdaq:
TLSA) ("Tiziana" or the "Company"), a biotechnology company developing breakthrough immunomodulation therapies
with its lead development candidate, intranasal foralumab, a fully human, anti-CD3 monoclonal antibody, today announced its participation
in the BIO-Europe 2024 conference, taking place November 4-6 in Stockholm, Sweden. As part of the conference's partnering meetings,
Tiziana will engage with industry leaders, potential collaborators, and investors to discuss recent clinical progress, including data
from its combination study involving Ozempic, a GLP-1 agonist.
The BIO-Europe conference provides a prestigious platform for Tiziana
to highlight its strategic advancements to the biopharma community, as well as to expand its partnerships aimed at accelerating the development
of its therapeutic pipeline. Key representatives from Tiziana will be available for discussions and will share data from our anti-CD3
and Ozempic combination study, which investigates the potential for enhanced therapeutic effects in targeted conditions. This latest clinical
update aligns with Tiziana's commitment to advancing therapies that address significant unmet medical needs.
"The BIO-Europe conference offers an ideal opportunity to highlight
our latest clinical findings, including the positive data from our GLP-1 combination study," said Ivor Elrifi, CEO of Tiziana Life
Sciences. "We will be engaging with prospective partners in Stockholm to explore collaborations that will further accelerate our
mission of delivering groundbreaking therapies to patients worldwide. We look forward to further advancing our Phase 2 studies following
on from the closing of a successful fundraise."
Foralumab, a fully human anti-CD3 monoclonal
antibody, is a biological drug candidate that has been shown to stimulate T regulatory cells when dosed intranasally. At present, 10 patients
with Non-Active Secondary Progressive Multiple Sclerosis (na-SPMS) have been dosed in an open-label intermediate sized Expanded Access
(EA) Program with either an improvement or stability of disease seen within 6 months in all patients. The FDA has recently allowed an
additional 20 patients to be enrolled in this EA program. In addition, intranasal foralumab is currently being studied in a Phase 2a,
randomized, double-blind, placebo-controlled, multicenter, dose-ranging trial in patients with non-active secondary progressive multiple
sclerosis (NCT06292923).
Activated T cells play an important role in the inflammatory process.
Foralumab, the only fully human anti-CD3 monoclonal antibody (mAb) currently in clinical development, binds to the T cell receptor and
dampens inflammation by modulating T cell function, thereby suppressing effector features in multiple immune cell subsets. This effect
has been observed in patients with COVID and with multiple sclerosis, as well as in healthy normal subjects. The non-active SPMS intranasal
foralumab Phase 2 trial (NCT06292923) began screening patients in November of 2023. Immunomodulation by nasal anti-CD3 mAb represents
a novel avenue for treatment of neuroinflammatory and neurodegenerative human diseases.[1],[2]
About Tiziana Life Sciences
Tiziana Life Sciences is a clinical-stage biopharmaceutical company
developing breakthrough therapies using transformational drug delivery technologies to enable alternative routes of immunotherapy. Tiziana's
innovative nasal approach has the potential to provide an improvement in efficacy as well as safety and tolerability compared to intravenous
(IV) delivery. Tiziana's lead candidate, intranasal foralumab, which is the only fully human anti-CD3 mAb currently in clinical
development, has demonstrated a favorable safety profile and clinical response in patients in studies to date. Tiziana's technology
for alternative routes of immunotherapy has been patented with several applications pending and is expected to allow for broad pipeline
For more information about Tiziana Life Sciences and its innovative
pipeline of therapies, please visit www.tizianalifesciences.com
For further inquiries:
Tiziana Life Sciences Ltd
Paul Spencer, Business Development and Investor Relations
+44 (0) 207 495 2379
email: info@tizianalifesciences.com