Full Press Release Details
Tiziana Life Sciences plc
("Tiziana" or the "Company")
Tiziana Life Sciences plc Announces Plans to
List Accustem Sciences Limited in the U.S.
YORK and LONDON , April 13, 2021 - Tiziana Life Sciences plc (NASDAQ: TLSA; LSE: TILS), today announced
that its former subsidiary, Accustem Sciences Limited ("Accustem"), intends to file a listing application with the Nasdaq Stock
Market shortly after completion of the distribution of shares in Accustem to Tiziana Life Sciences plc shareholders.
The board of directors of Accustem has resolved
that the Nasdaq listing venue is more appropriate to the nature of Accustem's business.
About Accustem Sciences
StemPrintER is a multi-gene prognostic assay intended
to predict the risk of recurrence of R+/HER2- breast cancer, and Spare, a derivative of StemPrintER, combines StemPrintER with two clinical
markers. This gives a more refined risk model.
These assays are intended for the prediction of
the risk of recurrence of breast cancer, based on the detection of 20 stem cell markers. The assay has been evaluated in an initial retrospective
validation study using a consecutive cohort of approximately 2,400 patients with breast cancer. Subsequently, StemPrintER has been further
validated in an independent retrospective cohort of more than 800 ER+/HER2- postmenopausal patients from the TransATAC trial.
A poster presented at the American Society of
Clinical Oncology (ASCO) Virtual Conference in May 2020, demonstrated the superiority of StemPrintER stem cell based genomic prognostic
tool versus the market leader, Oncotype DX, in predicting recurrence in ER+/HER2- postmenopausal breast cancer patients.
Endocrine receptor-positive (ER+) breast cancers
make up most breast cancer cases, however display significant variability in clinical behaviour, this makes prognosis and therapy response
challenging. Although the overall prognosis of patients is good, a significant proportion of these women will experience distant recurrence
in the first 10 years post-surgery.
For patients who also have a negative HER2 status
(HER2-) and risk of recurrence, the standard of care is endocrine therapy, with the addition of chemotherapy in patients. However, these
parameters are often insufficient to predict risk of recurrence in ER+/HER2- breast cancer patients, and consequently, these patients
are either over- or under-treated.
Accustem anticipates this prognostic test to be
used in conjunction with clinical evaluation to identify those patients at increased risk for early and/or late metastasis.
For further enquiries:
United Kingdom Investors:
Tiziana Life Sciences plc (TLSA)
U.S. Investor Relations Contact:
RedChip Companies, Inc.