Tiziana Life Sciences Ltd Notice of Annual General Meeting of Shareholders on Thursday 14th December 2023 at 8.30am EST/ 1.30pm UK TO BE HELD AS A "REMOTE MEETING" ONLY YOU ARE NOTIFIED that the 2023 annual general meeti

Tiziana Life Sciences Ltd

Notice of Annual General Meeting of Shareholders

on Thursday 14th December 2023 at 8.30am EST/ 1.30pm UK

TO BE HELD AS A "REMOTE MEETING"

YOU ARE NOTIFIED that the 2023 annual

general meeting ("AGM") of Tiziana Life Sciences Ltd (the "Company") will be held via video and

telephonic conference (in accordance with the Company's by-law 26.1) on Thursday 14th December at 8.30am EST/ 1.30pm

UK or as soon thereafter as is practicable for the purpose of transacting the following business:

Record Date: The record date for qualification

of shareholders of the Company ("Shareholders") to participate and vote in the AGM has been set for the end of trading

on Tuesday 12th December 2023.

Attending the Meeting: All Shareholders are invited to participate

in the AGM. The electronic system for remote participation will be available for access from 8.15am EST/ 1.15pm UK on Thursday 14th

To join the meeting type (or paste) the following web address into

The password to join the meeting is "252851"

The Webinar ID number is: 833 1450 5378

Notice of Tiziana Life Sciences Ltd Annual General Meeting 2023 1

If you wish, you may join by phone

+16699006833,,83314505378# US (San Jose)

+17193594580,,83314505378# US

Dial (for higher quality, dial a number based on your current location):

+1 253 215 8782 US (Tacoma)

+1 346 248 7799 US (Houston)

+1 929 205 6099 US (New York)

+1 301 715 8592 US (Washington DC)

+1 312 626 6799 US (Chicago)

Further guidance and instructions are available by emailing: info@tizianalifesciences.com

Voting: We encourage you to vote as promptly as possible by

mailing your completed and signed proxy card. Please follow the directions on the proxy card. You may also vote during the meeting, the

chairman of the meeting shall direct you on how you may cast your vote on a show of hands.

Notice of Tiziana Life Sciences Ltd Annual General Meeting 2023 2

Notice of meeting and Resolutions to be proposed

Notice is hereby given that the AGM of Tiziana

Life Sciences Ltd will be held as a remote meeting only on Thursday 14th December 2023, commencing at 8.30am EST/ 1.30pm UK

for the transaction of the following business.

The Board considers that Resolutions 1 to 3 are in the best interests

of the Company and its Shareholders as a whole and recommends that you vote in favour of these Resolutions. Resolutions 1 to 3 will be

proposed as ordinary resolutions. Voting on all of the resolutions will be conducted on a poll.

To re-elect Gabriele Cerrone as a director.

See biography on page 4.

To receive the 2022 Annual Accounts for the year ended 31 December

See notes on page 4.

Reappointment of auditors and fixing of auditors' remuneration

To reappoint PKF LittleJohn LLP as auditors from

the conclusion of the meeting until the conclusion of the next general meeting before which accounts are laid and to authorise the directors

to fix the auditors' remuneration.

See notes on page 4.

Notice of Tiziana Life Sciences Ltd Annual General Meeting 2023 3

Notes to Resolutions

Notes to Resolution 1

Re-appointment of Gabriele Cerrone as a director

Mr Cerrone retires and offers himself for reappointment.

Mr Cerrone has a successful track record and extensive

experience in the financing and restructuring of microcap biotechnology companies. He has founded nine biotechnology companies in oncology,

infectious diseases and molecular diagnostics, and has taken six of these companies to the NASDAQ Market and one to the AIM Market in

London. Mr Cerrone co-founded Trovagene, Inc. (NASDAQ: TROV), a molecular diagnostic company and served as its Co-Chairman; he was a co-founder

and served as Chairman of both Synergy Pharmaceuticals, Inc. (NASDAQ: SGYP) and Callisto Pharmaceuticals, Inc. (OTCMKTS: CLSP), and was

a Director of and led the restructuring of Siga Technologies, Inc. (NASDAQ: SIGA). Mr Cerrone also co-founded FermaVir Pharmaceuticals,

Inc. and served as Chairman of the Board until its merger in September 2007 with Inhibitex, Inc. Mr Cerrone served as a director of Inhibitex,

Inc. until its US$2.5bn sale to Bristol Myers Squibb Co in 2012.

Mr Cerrone is the Executive Chairman and Co-Founder

of Gensignia Life Sciences, Inc., a molecular diagnostics company focused on oncology using microRNA technology; Chairman and Founder

of Tiziana Life Sciences plc (AIM: TILS/ NASDAQ:TLSA) an oncology focused therapeutics company; Chairman and Co-Founder of Rasna Therapeutics

Limited, a company focused on the development of therapeutics for leukaemias; Co-Founder of ContraVir Pharmaceuticals, Inc. (NASDAQ: CTRV);

and founder of BioVitas Capital Ltd.

Notes to Resolution 2

Reports and accounts

The Board will present its reports and the accounts for the year ended

31 December 2022 (2022 Accounts), as contained in the Annual Report.

Notes to Resolution 3

Reappointment of Auditor and fixing of Auditors' remuneration

At each general meeting at which the accounts

are laid before the members, the Company is required to appoint an auditor to serve until the next such meeting. It is proposed that

PKF Littlejohn LLP be reappointed as the Company's auditor.

Notice of Tiziana Life Sciences Ltd Annual General