Tiziana Life Sciences Announces Purchase of Common Shares by Chairman and Acting CEO New York

Tiziana Life Sciences Announces Purchase of

Common Shares by Chairman and Acting CEO

New York, March 21, 2023 - Tiziana

Life Sciences Ltd. (Nasdaq: TLSA) ("Tiziana" or the "Company"), a biotechnology company enabling breakthrough

immunotherapies via novel routes of drug delivery, today announces that it has been notified that Gabriele Cerrone, its Chairman and Acting

Chief Executive Officer, purchased 7,500 common shares at $0.79 per share, bringing his total holding to 38,693,237 common shares.

Activated T cells play an important role in the

inflammatory process. Foralumab, the only fully human anti-CD3 monoclonal antibody (mAb), binds to the T cell receptor, dampens inflammation

by modulating T cell function, thereby suppressing effector features in multiple immune cell subsets, an effect demonstrated in patients

with COVID and with multiple sclerosis, as well as in healthy normal subjects. Intranasal foralumab Phase 2 trials are expected to start

in Q3 2023 in patients with non-active SPMS. Immunomodulation by nasal anti-CD3 mAb represents a novel avenue for treatment of inflammatory

About Tiziana Life Sciences

Tiziana Life Sciences is a clinical-stage

biopharmaceutical company developing breakthrough therapies using transformational drug delivery technologies to enable alternative routes

of immunotherapy. Tiziana's innovative nasal, oral and inhalation approaches in development have the potential to provide an improvement

in efficacy as well as safety and tolerability compared to intravenous (IV) delivery. Tiziana's lead candidate, intranasal foralumab,

the only fully human anti-CD3 mAb, has demonstrated a favorable safety profile and clinical response in patients in studies to date. Tiziana's

technology for alternative routes of immunotherapy has been patented with several applications pending and is expected to allow for broad

pipeline applications.

For further inquiries:

Tiziana Life Sciences Ltd

Paul Spencer, Business Development and Investor Relations

+44 (0) 207 495 2379

LifeSci Advisors, LLC