Full Press Release Details
Tiziana Life Sciences Announces Discovery of
Biomarkers in Multiple Sclerosis Patients Treated with
NEW YORK, January 22, 2025 - Tiziana Life Sciences, Ltd. (Nasdaq:
TLSA) ("Tiziana" or the "Company"), a biotechnology company developing breakthrough immunomodulation therapies
with its lead development candidate, intranasal foralumab, a fully human, anti-CD3 monoclonal antibody, today announced the discovery
of new immune biomarkers in patients with non-active secondary progressive multiple sclerosis (na-SPMS) treated with nasal foralumab.
We believe these findings contribute substantially to our understanding of the immune mechanisms underlying the effects of nasal foralumab.
The study identified gene expression changes which were detected beginning
three months after intranasal dosing of foralumab in our ongoing ISPPEA (or expanded access program). Key findings include modulation
These pathways are known to be associated with antigen presentation,
interferon responses, and other regulatory immune mechanisms.
In this study, single-cell RNA sequencing (scRNAseq) of peripheral blood
samples taken before and at three and six months after drug administration has revealed relevant gene expression changes associated with
nasal foralumab, which has been associated with a reduction in microglial brain inflammation, as measured by advanced microglial PET scans
in these same patients.
"We are excited to announce this breakthrough in understanding
how nasal foralumab induces immune modulation in Secondary Progressive MS patients," said Dr. Tanuja Chitnis, M.D., Principal Investigator
and Professor of Neurology at Harvard Medical School and senior neurologist at Brigham and Women's Hospital, a founding member of
Mass General Brigham Healthcare System. "These findings highlight the potential of nasal foralumab in modulating critical immune
pathways and offer new insights into its clinical effects. This discovery represents a pivotal step toward personalized treatment strategies
for MS. We look forward to submitting these data to a peer reviewed journal"
"The observed clinical stabilization and microglial PET findings
are supported by these new biomarker discoveries, providing compelling evidence of nasal foralumab's biological effects," said Dr.
Howard Weiner, Chairman of Tiziana's Scientific Advisory Board and co-director of the Ann Romney Center for Neurologic Diseases
at Brigham and Women's Hospital, a founding member of Mass General Brigham healthcare system. "The identification of these
biomarkers not only strengthens our understanding of the treatment's mechanism but also establishes a framework for monitoring its
efficacy in future trials and may establish a framework for monitoring a patient's response to foralumab treatment."
"This data, and its implications, underscores our commitment to
advancing innovative therapies for neurodegenerative diseases," commented Ivor Elrifi, CEO of Tiziana Life Sciences. "Foralumab,
the first fully human anti-CD3 monoclonal antibody, is in a Phase 2 trial as a groundbreaking immunomodulatory therapy with applications
in autoimmune and neurodegenerative diseases. These findings further confirm its potential and set the stage for broader clinical exploration."
The FDA defines a biomarker as a defined characteristic that is measured
as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic
interventions. Molecular, histologic, radiographic, or physiologic characteristics are types of biomarkers. A biomarker is not an assessment
of how an individual feels, functions, or survives.
Foralumab, a fully human anti-CD3 monoclonal antibody, is a biological
drug candidate that has been shown to stimulate T regulatory cells when dosed intranasally. At present, 10 patients with Non-Active Secondary
Progressive Multiple Sclerosis (na-SPMS) have been dosed in an open-label intermediate sized Expanded Access (EA) Program with either
an improvement or stability of disease seen within 6 months in all patients. The FDA has recently allowed an additional 20 patients to
be enrolled in this EA program. In addition, intranasal foralumab is currently being studied in a Phase 2a, randomized, double-blind,
placebo-controlled, multicenter, dose-ranging trial in patients with non-active secondary progressive multiple sclerosis (NCT06292923).
Activated T cells play an important role in the inflammatory process.
Foralumab, the only fully human anti-CD3 monoclonal antibody (mAb) currently in clinical development, binds to the T cell receptor and
dampens inflammation by modulating T cell function, thereby suppressing effector features in multiple immune cell subsets. This effect
has been observed in patients with COVID and with multiple sclerosis, as well as in healthy normal subjects. The non-active SPMS intranasal
foralumab Phase 2 trial (NCT06292923) began screening patients in November of 2023. Immunomodulation by nasal anti-CD3 mAb represents
a novel avenue for treatment of neuroinflammatory and neurodegenerative human diseases.1,2
About Tiziana Life Sciences
Tiziana Life Sciences is a clinical-stage biopharmaceutical company
developing breakthrough therapies using transformational drug delivery technologies to enable alternative routes of immunotherapy. Tiziana's
innovative nasal approach has the potential to provide an improvement in efficacy as well as safety and tolerability compared to intravenous
(IV) delivery. Tiziana's lead candidate, intranasal foralumab, which is the only fully human anti-CD3 mAb currently in clinical
development, has demonstrated a favorable safety profile and clinical response in patients in studies to date. Tiziana's technology
for alternative routes of immunotherapy has been patented with several applications pending and is expected to allow for broad pipeline
For more information about Tiziana Life Sciences and its innovative
pipeline of therapies, please visit www.tizianalifesciences.com.
Forward-Looking Statements
Certain statements made in this announcement are forward-looking statements.
These forward-looking statements are not historical facts but rather are based on the Company's current expectations, estimates, and projections
about its industry, its beliefs, and assumptions. Words such as anticipates,' expects,' intends,' plans,' believes,' seeks,' estimates,'
and similar expressions are intended to identify forward-looking statements. These statements are not guarantees of future performance
and are subject to known and unknown risks, uncertainties, and other factors, some of which are beyond the Company's control, are difficult
to predict, and could cause actual results to differ materially from those expressed or forecasted in the forward-looking statements.
The Company cautions security holders and prospective security holders not to place undue reliance on these forward-looking statements,
which reflect the view of the Company only as of the date of this announcement. Actual
results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including:
the uncertainties related to market conditions and other factors described more fully in the section entitled Risk Factors'
in Tiziana's Annual Report on Form 20-F for the year ended December 31, 2023, and other periodic reports filed with the Securities
and Exchange Commission.The forward-looking statements made in this announcement relate only to events as of the date on which
the statements are made. The Company will not undertake any obligation to release publicly any revisions or updates to these forward-looking
statements to reflect events, circumstances, or unanticipated events occurring after the date of this announcement except as required
by law or by any appropriate regulatory authority.
For further inquiries:
Tiziana Life Sciences Ltd
Paul Spencer, Business Development, and Investor Relations
+44 (0) 207 495 2379
email: info@tizianalifesciences.com