THE INFORMATION CONTAINED IN THIS ANNOUNCEMENT IS DEEMED BY THE COMPANY TO CONSTITUTE INSIDE INFORMATION AS STIPULATED UNDER THE EU MARKET ABUSE REGULATION (596/2014). UPON PUBLICATION OF THE ANNOUNCEMENT VIA A REGULATOR

INFORMATION CONTAINED IN THIS ANNOUNCEMENT IS DEEMED BY THE COMPANY TO CONSTITUTE INSIDE INFORMATION AS STIPULATED UNDER THE EU

MARKET ABUSE REGULATION (596/2014). UPON PUBLICATION OF THE ANNOUNCEMENT VIA A REGULATORY INFORMATION SERVICE, THIS INFORMATION

IS CONSIDERED TO BE IN THE PUBLIC DOMAIN.

"Company", "Tiziana Life Sciences" or "Tiziana")

on IND Application for Oral Formulation of Foralumab for Treatment of NASH

Life Sciences plc (NASDAQ: TLSA; AIM: TILS), a US and UK biotechnology company that focuses on the discovery and development

of novel molecules to treat human diseases in oncology and immunology, announces an update regarding its Investigational New Drug

application ("IND") to the U.S. Food and Drug Administration (FDA) to initiate a Phase 1 clinical trial of enteric-coated

capsules of Foralumab in healthy volunteers.

completion of the 30 calender day review, FDA has requested more information and safety data from the ongoing phase 1 trial with

nasal administration of foralumab to justify the proposed dose-range for the phase 1 trial with oral administration of enteric-coated

capsules of foralumab in healthy volunteers. The stability data on the dose-range of 10-250 mg of foralumab was included in the

submitted IND for the ongoing phase 1 trial with nasal administration. FDA also advised us to adequately cross-reference the submitted

IND with nasal administration. Accordingly, we have withdrawn the current IND to include safety data from the ongoing trial with

nasal administration and adequately cross-reference the IND for nasal administration with solution of foralumab.

ongoing phase 1 trial with nasal administration of foralumab has completed the first two doses (10 and 50 mg) and the highest

dose 250 mg is currently ongoing, and is expected to be completed by May 15, 2019. Upon completion, the safety data from this

ongoing phase 1 trial with nasal administration will be provided to FDA as part of the revised IND for oral administration of

enteric-coated capsules of foralumab in healthy volunteers. A further announcement will be made in due course following receipt

of a response from FDA.

Kunwar Shailubhai, Chief Executive Officer and Chief Scientific Officer of the Company stated "We are in agreement and believe

that FDA recommendations will further strenghthen our IND for evaluation of oral enteric-coated capsules of foralumab in healthy

person who arranged for the release of this announcement on behalf of the Company was Dr Kunwar Shailubhai, CEO of Tiziana.