TG Therapeutics, Inc. Announces Fourth Quarter and Year-End 2014 Financial Results and Business Update Investor Conference Call to be held Thursday

TG Therapeutics, Inc. Announces Fourth Quarter and Year-End

2014 Financial Results and Business Update

Investor Conference Call to be held Thursday, March 12, 2015

New York, NY, (March 11, 2015) - TG Therapeutics,

Inc. (NASDAQ:TGTX) today announced its financial results for the fourth quarter and year ended December 31, 2014 and provided recent

company developments along with a business outlook for 2015.

"2014 was an exciting and productive year for TG Therapeutics

as we continued to aggressively move forward with the development of our lead drug candidates, TG-1101 and TGR-1202. We ended the

year on a high note presenting a significant amount of data at the American Society of Hematology meeting. In addition to very

encouraging data on the combination of TG-1101 and TGR-1202, we also presented data demonstrating high response rates for the combination

of TG-1101 and ibrutinib, data that we believe supports our now on-going Phase 3 trial of that combination being conducted under

a Special Protocol Assessment," stated Michael S. Weiss, the Company's Executive Chairman and Interim Chief Executive Officer.

"With TG-1101 and TGR-1202, we believe we have two drug candidates each with safety and efficacy profiles that are differentiated

and uniquely suited for combination therapy, both with other novel agents, but most importantly, together in our proprietary 1303'

combination regimen. For 2015, we plan to focus on recruitment into our GENUINE Phase 3 study, as well as our planned first Phase

3 clinical trial of the combination of TG-1101 and TGR-1202, with a longer term vision toward additional combination trials with

the goal of continuing to push toward better patient outcomes."

Recent Developments & Highlights

Key Objectives for 2015

Financial Results for the Fourth Quarter and Full Year

At December 31, 2014, the Company had cash, cash equivalents,

investment securities, and interest receivable of $78.9 million, as compared to $45.4 million at December 31, 2013.

Pro-forma cash, cash equivalents, investment securities, and

interest receivable as of December 31, 2014 are approximately $98.2 million, including $19.3 million of net proceeds from the utilization

of the Company's at-the-market ("ATM") sales facility during the first quarter of 2015.

Our consolidated net loss for the year ended December 31, 2014,

excluding non-cash items and a one-time upfront cash milestone payment, was approximately $25.3 million. The consolidated net loss

for the year ended December 31, 2014, inclusive of the items above, was $55.8 million, or $1.64 per diluted share, compared to

a consolidated net loss of $20.5 million for the year ended December 31, 2013, representing an increase in consolidated net loss

of $35.3 million. The increase in consolidated net loss during the year ended December 31, 2014 was primarily the result of $8.1

million of expense ($4.1 million of which was non-cash stock expense) recorded in conjunction with the Company's conversion

from a JV agreement to a licensing agreement for TGR-1202, $1.2 million in non-cash stock expense recorded in conjunction with

the licensing arrangement for the IRAK4 inhibitors program, and a $15.9 million increase in non-cash compensation expense related

to equity incentive grants. Exclusive of the items mentioned above, other research and development expenses for TG-1101 and TGR-1202

increased $7.1 million and $3.8 million, respectively, over the comparable period in 2013.

Our consolidated net loss for the fourth quarter ended December

31, 2014, excluding non-cash items, was approximately $13.8 million, which included approximately $8.9 million of manufacturing

and CMC readiness expenses in preparation for Phase 3 clinical trials and commercialization. The consolidated net loss for the

fourth quarter ended December 31, 2014, inclusive of non-cash items, was $18.8 million, or $0.48 per diluted share, compared to

a consolidated net loss of $5.7 million during the comparable quarter in 2013, representing an increase in consolidated net loss

of $13.1 million. The increase in consolidated net loss during the fourth quarter ended December 31, 2014 was primarily the result

of other research and development expenses for TG-1101 and TGR-1202 increasing $9.0 million and $0.2 million, respectively, over

the comparable period in 2013. The increase in other research and development expenses related to TG-1101 was primarily the result

of increased manufacturing and clinical trial expenses in preparation for the launch of Phase 3 registration programs. Also contributing

to the increase in consolidated net loss during the quarter ended December 31, 2014 was a $4.1 million increase in non-cash compensation

expense related to equity incentive grants.

The Company will host an investor conference call Thursday,

March 12, 2015, at 8:30am ET, to discuss the Company's 2014 financial results and provide a business outlook for 2015.

In order to participate in the conference call, please call

1-877-407-8029 (U.S.), 1-201-689-8029 (outside the U.S.), Conference Title: TG Therapeutics Year-End 2014 Earnings Call. A live

webcast of this presentation will be available on the Events page, located within the Investors & Media section, of the Company's

website at www.tgtherapeutics.com. An audio recording of the conference call will also be available for replay at www.tgtherapeutics.com,

for a period of 30 days after the call.

ABOUT TG THERAPEUTICS, INC.

TG Therapeutics is a biopharmaceutical company focused on the

acquisition, development and commercialization of novel treatments for B-cell malignancies and autoimmune diseases. Currently,

the company is developing two therapies targeting hematological malignancies. TG-1101 (ublituximab) is a novel, glycoengineered

monoclonal antibody that targets a specific and unique epitope on the CD20 antigen found on mature B-lymphocytes. TG Therapeutics

is also developing TGR-1202, an orally available PI3K delta inhibitor. The delta isoform of PI3K is strongly expressed in cells

of hematopoietic origin and is believed to be important in the proliferation and survival of B-lymphocytes. Both TG-1101 and TGR-1202

are in clinical development for patients with hematologic malignancies. The Company also has a pre-clinical program to develop

IRAK4 inhibitors, as well as an antibody research program to develop anti-PD-L1 and anti-GITR antibodies. TG Therapeutics is headquartered

Cautionary Statement

Some of the statements included in this press release, particularly

those with respect to anticipating future clinical trials, the timing of commencing or completing such trials and business prospects

for TG-1101, TGR-1202, the IRAK4 inhibitor program, and the anti-PD-L1 and anti-GITR antibodies may be forward-looking statements

that involve a number of risks and uncertainties. For those statements, we claim the protection of the safe harbor for forward-looking

statements contained in the Private Securities Litigation Reform Act of 1995. Among the factors that could cause our actual results

to differ materially are the following: our ability to successfully and cost-effectively complete pre-clinical and clinical trials

for TG-1101, TGR-1202, the IRAK4 inhibitor program and the anti-PD-L1 and anti-GITR antibodies; the risk that early pre-clinical

and clinical results that supported our decision to move forward with TG-1101, TGR-1202, the IRAK4 inhibitor program and the anti-PD-L1

and anti-GITR antibodies will not be reproduced in additional patients or in future studies; the risk that trends observed which

underlie certain assumptions of future performance of TGR-1202 will not continue, the risk that TGR-1202 will not produce satisfactory

safety and efficacy results to warrant further development following the completion of the current Phase 1 study; the risk that

the data (both safety and efficacy) from future clinical trials will not coincide with the data produced from prior pre-clinical

and clinical trials; the risk that trials will take longer to enroll than expected; our ability to achieve the milestones we project

over the next year; our ability to manage our cash in line with our projections, and other risk factors identified from time to

time in our reports filed with the Securities and Exchange Commission. Any forward-looking statements set forth in this press release

speak only as of the date of this press release. We do not undertake to update any of these forward-looking statements to reflect

events or circumstances that occur after the date hereof. This press release and prior releases are available at www.tgtherapeutics.com.

The information found on our website is not incorporated by reference into this press release and is included for reference purposes

Director- Investor Relations

TG Therapeutics, Inc.

Telephone: 212.554.4351

Email: ir@tgtxinc.com

TG Therapeutics, Inc.

Selected Consolidated Financial Data

Statements of Operations Information

Balance Sheet Information:

* Condensed from audited financial statements.