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Spyre Therapeutics to Host Conference Call and Webcast to Report Interim Results from Phase 1 Healthy Volunteer Trials for its SPY002 Program, its Novel Half-Life Extended Anti-TL1A Antibodies on June 17, 2025

Key Takeaway: Spyre Therapeutics will announce interim results from its Phase 1 healthy volunteer trials for the SPY002 program on June 17, 2025. Following this announcement, the company will host a conference call and webcast to discuss the results. The SPY002 program focuses on developing novel half-life extended anti-TL1A antibodies for treating inflammatory bowel disease.
Price reaction · baseline $17.18 (2025-06-16 close) · hit after-hours · 1 other SYRE headline(s) in the window, move may be shared
day 0 close
-11.6%
day 1
-12.2%
day 3 · peak
-14.6%

Market Sentiment Analysis

POSITIVE FACTORS

  • Spyre Therapeutics is advancing innovative antibody engineering.
  • The company is reporting interim results from its Phase 1 trials.
  • The SPY002 program targets inflammatory bowel disease effectively.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+249%
120-day peak, hindsight
Typical move
3.2%
average across 3 past catalysts
Cash runway
~49 mo
Minimal dilution risk
Lead asset
Co-ArgI-PEG modified human arginase I
Phase 2 · Acute Myeloid Leukemia

Full Press Release Details

WALTHAM, Mass.,June 16, 2025/PRNewswire/ -- Spyre Therapeutics, Inc. (NASDAQ:SYRE), a clinical-stage biotechnology company advancing best-in-class antibody engineering, dose optimization, and rational therapeutic combinations for the treatment of Inflammatory Bowel Disease ("IBD") and other immune-mediated diseases, today announced it will report interim results from the Phase 1 SPY002 healthy volunteer trials onTuesday, June 17, 2025. Following the announcement, the Company will host a conference call and webcast at8:00am ETto discuss the results.
To access the live and archived webcast, please visit the Investor Relations page of Spyre's website athttps://ir.spyre.com/events-and-presentations. The archived webcast will be available for a limited time on the Company's website.

About Spyre Therapeutics

Spyre Therapeutics is a clinical-stage biotechnology company that aims to create next-generation inflammatory bowel disease (IBD) and other immune-mediated disease products by combining best-in-class antibody engineering, dose optimization, and rational therapeutic combinations. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.
For more information, please visithttp://spyre.com.

Frequently Asked Questions

When will Spyre report the Phase 1 trial results?

Spyre Therapeutics will report interim results on June 17, 2025.

What is the focus of the SPY002 program?

The SPY002 program targets novel half-life extended anti-TL1A antibodies.

How can I access the conference call?

You can access the conference call and webcast on Spyre's Investor Relations page.

What diseases does Spyre aim to treat?

Spyre focuses on inflammatory bowel disease and other immune-mediated diseases.

Last updated: Jun 16, 2025