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RESIGNATION LETTER

Key Takeaway: Aeglea BioTherapeutics, Inc. To the Board of Directors: Effective as of the date written above, I hereby voluntarily resign (i) as a member of the Board of Directors (the Board ) of Aeglea BioTherapeutics, Inc. (together with its subsidiaries, the Company ) and as a member of

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Aeglea BioTherapeutics, Inc.
To the Board of Directors:
Effective as of the date written above, I hereby voluntarily resign (i) as a member of the Board of Directors (the Board ) of
Aeglea BioTherapeutics, Inc. (together with its subsidiaries, the Company ) and as a member of each committee of the Board on which I may serve and (ii) from any and all officer and employment positions of the Company,
including without limitation as the Chief Executive Officer of the Company.
Sincerely,
/s/ David G. Lowe
David G. Lowe
Last updated: Jul 18, 2017