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SS Innovations to Submit De Novo Application to the FDA for the SSi Mantra 3 Surgical Robotic System for Multiple Indications All Clinical Data Validated by Leading Third-Party CRO for Safety, Feasibility and Efficacy Fo

Key Takeaway: SS Innovations International, Inc. plans to submit a De Novo Classification Request to the FDA for the SSi Mantra 3 surgical robotic system in July 2025. The system has been used in over 3,800 surgeries without complications, supported by validated clinical data from a leading contract research organization. The application aims to facilitate the system's use in multiple surgical specialties including urology and cardiac surgery. Additionally, the company is pursuing CE Mark approval in the European Union.

Market Sentiment Analysis

POSITIVE FACTORS

  • SS Innovations has validated clinical data from a leading CRO, suggesting the safety and efficacy of their robotic system.
  • The SSi Mantra system has successfully performed over 3,800 surgeries with no reported complications.
  • The application for FDA approval indicates confidence in bringing innovative surgical technology to the U.S. market.

CONCERNS & RISKS

  • The De Novo application to the FDA does not guarantee approval.
  • SS Innovations' expansion and plans hinge on regulatory approvals, which can be unpredictable.

Full Press Release Details

Innovations to Submit De Novo Application to the FDA for the SSi Mantra 3 Surgical Robotic System for Multiple Indications
Clinical Data Validated by Leading Third-Party CRO for Safety, Feasibility and Efficacy
Lauderdale, FL - May 8, 2025 - SS Innovations International, Inc. (the
"Company" or "SS Innovations") (Nasdaq: SSII), a developer of innovative surgical robotic technologies dedicated
to making robotic surgery affordable and accessible to a global population, today announced that the Company is planning to submit a
De Novo Classification Request to the U.S. Food and Drug Administration (the "FDA") for the SSi Mantra 3 surgical robotic
system (the "SSi Mantra 3") in July 2025.
approved by the FDA, the SSi Mantra 3 would be cleared to market in the United States. Submission of the De Novo Classification Request
does not guarantee FDA approval.
the Company began the sale of its system in August 2022 it has installed a total of 80 SSi Mantra robotic surgical systems in 75 hospitals
and over 3,800 surgeries have been performed, including over 200 robotic cardiac surgeries. The SSi Mantra 3 version was launched in
June 2024, and the Company has already installed 37 systems that have been utilized to perform more than 750 multispecialty robotic surgical
procedures, including 70 cardiac cases, with no device related mortality, injury or complications.
world clinical data, validated by a leading contract research organization ("CRO"), supports the ability of the SSi Mantra
3 to safely perform a wide variety of surgical procedures. The planned submission of the SSi Mantra 3 to the FDA will include an application
for multispecialty indications including urology, gynecology, general surgery, and thoracic and cardiac surgery.
Sudhir Srivastava, Chairman of the Board and Chief Executive Officer of SS Innovations, commented, "We currently have approval
to market our SSi Mantra surgical robotic system in seven countries and continue to advance our global expansion. We are taking important
steps, including the planned De Novo application to the FDA, to introduce our empowering, cost-effective surgical robotic technology
to the U.S. market. In parallel, we are pursuing European Union CE Mark approval for our SSi Mantra surgical robotic system and look
forward to our future with great confidence."
Innovations International, Inc. (Nasdaq: SSII) develops innovative surgical robotic technologies with a vision to make the benefits of
robotic surgery affordable and accessible to a larger segment of the global population. The Company's product range includes its
proprietary "SSi Mantra" surgical robotic system and its comprehensive suite of "SSi Mudra" surgical instruments,
which support a variety of surgical procedures including robotic cardiac surgery. An American company headquartered in India, SS Innovations
plans to expand the global presence of its technologically advanced, user-friendly, and cost-effective surgical robotic solutions. Visit
the Company's website at ssinnovations.com or LinkedIn
for more information and updates.
SSi Mantra Surgical Robotic System is a user-friendly, modular, multi-arm system with many advanced technology features, including: 3
to 5 modular robotic arms, an open-faced ergonomic surgeon command center, a large 3D 4K monitor, a touch panel monitor for all patient
related information display, a virtual real-time image of the robotic patient side arm carts, and the ability for superimposition of
3D models of diagnostic imaging. A vision cart provides the table-side team with the same magnified 3D 4K view as the surgeon to provide
better safety and efficiency. The SSi Mantra utilizes over 40 different types of robotic endo-surgical instruments to support different
specialties, including cardiac surgery. The SSi Mantra has been clinically validated in India in more than 100 different types of surgical
press release may contain statements that are not historical facts and are considered forward-looking within the meaning of the Private
Securities Litigation Reform Act of 1995. The words "anticipate," "assume," "believe," "estimate,"
"expect," "will," "intend," "may," "plan," "project," "should,"
"could," "seek," "designed," "potential," "forecast," "target,"
"objective," "goal," or the negatives of such terms or other similar expressions to identify such forward-looking
statements. These statements relate to future events or SS Innovations International's future financial performance and involve
known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance, or achievements
to be materially different from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking
Sullivan, Managing Director

Frequently Asked Questions

What is the SSi Mantra 3 surgical robotic system?

The SSi Mantra 3 is a versatile surgical robotic system designed for multiple specialties.

When will the De Novo application for SSi Mantra 3 be submitted to the FDA?

The De Novo application is planned for submission to the FDA in July 2025.

How many SSi Mantra robotic systems have been sold?

As of now, 80 SSi Mantra robotic systems have been installed in 75 hospitals.

What types of surgeries can the SSi Mantra 3 perform?

The system is validated for a variety of surgeries, including urology and cardiac.

What is the goal of SS Innovations International?

The goal is to make robotic surgery affordable and accessible to a global audience.

Last updated: May 8, 2025