Full Press Release Details
Silverback Therapeutics Reports Second Quarter 2021 Financial Results and Provides Business Update
SEATTLE August 12, 2021 Silverback Therapeutics, Inc. (Nasdaq: SBTX) ( Silverback ), a clinical-stage
biopharmaceutical company leveraging its proprietary ImmunoTAC technology platform to develop systemically delivered, tissue targeted therapeutics for the treatment of cancer, chronic viral infections, and other serious diseases, today reported
financial results for the second quarter ended June 30, 2021 and provided a business update.
The second quarter was notable for the
significant progress we made across our entire pipeline of tissue-targeted therapies, with SBT6050, our HER2-TLR8 ImmunoTAC leading the way with continued robust enrollment in our Phase 1/1b study, said Laura Shawver, Ph.D., chief executive
officer of Silverback. We are deeply appreciative of the patients, their families, and our clinical investigators who continue to contribute to the SBT6050-101 clinical trial, and we look forward to
providing the first update of the clinical data at the ESMO conference in September.
Title: Interim results of a Phase 1/1b study of SBT6050 monotherapy and pembrolizumab combination in patients with advanced
HER2-expressing or amplified solid tumors Klempner, S., et al.
Session Date and Time: The ePoster will be released virtually on Thursday, September
16th at 8:30 AM Central European Summer Time / 2:30 AM Eastern Standard Time
Second Quarter Financial Results
For the second quarter ended June 30, 2021, Silverback reported a net loss of $24.5 million, compared to a net loss of $6.5 million for the
comparable period in 2020. For the six months ended June 30, 2021, Silverback reported a net loss of $43.4 million, compared to a net loss of $11.7 million for the comparable period in 2020. Included in the net losses for the three
and six months ended June 30, 2021 were $4.7 million and $9.0 million of non-cash stock-based compensation compared to $128,000 and $175,000 for the same periods in 2020.
Research and development expenses for the second quarter ended June 30, 2021 were $17.7 million, compared to $5.1 million for the same period
in 2020. Research and development expenses for the six months ended June 30, 2021 were $30.0 million compared to $9.5 million for the same period in 2020. The increases in the Company s research and development expenses in 2021
were primarily attributable to the advancement of pipeline programs, including SBT6290 and SBT8230, through preclinical development and the continued clinical development of SBT6050. Silverback also incurred additional personnel-related expenses as
operations grew in support of program advancements.
General and administrative expenses for the second quarter ended June 30, 2021 were
$6.8 million, compared to $1.3 million for the same period in 2020. General and administrative expenses for the six months ended June 30, 2021 were $13.4 million, compared to $2.2 million for the same period in 2020. The
increases in general and administrative expenses were primarily attributable to an increase in personnel-related expenses due to increased headcount in 2021, including new executives, as well as increases in salaries, bonuses, and stock-based
compensation. The increases in general and administrative expenses were also due to an increase in legal fees, professional fees, and other various general and administrative expenses as we now operate as a public company.
As of June 30, 2021, Silverback reported cash and cash equivalents of $359.7 million, compared to $386.6 million at December 31, 2020,
which is expected to fund operating expenses and capital expenditure requirements for at least the next 24 months.
About Silverback Therapeutics
Silverback Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on leveraging its proprietary ImmunoTAC technology platform to
develop systemically delivered and tissue targeted therapeutics for the treatment of cancer, chronic viral infections, and other serious diseases. Silverback s platform enables the strategic pairing of proprietary payloads that modulate key
disease modifying pathways with monoclonal antibodies directed at specific disease sites. Initially, Silverback is creating a new class of targeted immuno-oncology agents that direct a TLR8 agonist myeloid cell activator to the tumor
microenvironment in solid tumors to promote cancer cell killing. Silverback Therapeutics is located in Seattle, Washington. To learn more, visit www.silverbacktx.com.
Forward-Looking Statements
This news release contains certain forward-looking statements that involve risks and uncertainties that could cause actual results to be materially different
from historical results or from any future results expressed or implied by such forward-looking statements. Such forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations
concerning, among other things, Silverback s plans and ability to bring new treatments to patients in need, the progress and expected timing of Silverback s drug development programs and clinical trials, the strength of Silverback s
balance sheet and the adequacy of cash on hand. Factors that may cause actual results to differ materially include the risk that compounds that appeared promising in early research or clinical trials do not demonstrate safety and/or efficacy in
later preclinical studies or clinical trials, the risk that Silverback may not obtain approval to market its product candidates, uncertainties associated with performing clinical trials, regulatory filings and applications, risks associated with
reliance on third parties to successfully conduct clinical trials, risks associated with the impact of the COVID-19 pandemic on our business and the global economy, the risks associated with reliance on
outside financing to meet capital requirements, the risks associated with losing key members of management and other risks associated with the process of discovering, developing and commercializing drugs that are safe and effective for use as human
therapeutics, and in the endeavor of building a business around such drugs. You are urged to consider statements that include the words may, will, would, could, should,
believes, estimates, projects, promise, potential, expects, plans, anticipates, intends, continues, designed,
goal, or the negative of those words or other comparable words to be uncertain and forward-looking. For a further list and description of the risks and uncertainties that Silverback faces, please refer to Silverback s periodic and
other filings with the Securities and Exchange Commission, which are available at www.sec.gov. Such forward-looking statements are current only as of the date they are made, and Silverback assumes no obligation to update any
forward-looking statements, whether as a result of new information, future events or otherwise.
Silverback Therapeutics
Canale Communications
Silverback Therapeutics, Inc.
Condensed Balance Sheets
(in thousands, except share and par value data)
| June 30, 2021 | December 31, 2020 | |||||||
| (unaudited) | ||||||||
| Assets | ||||||||
| Current assets: | ||||||||
| Cash and cash equivalents | $ | 359,689 | $ | 386,569 | ||||
| Prepaid expenses and other current assets | 3,338 | 4,087 | ||||||
| Total current assets | 363,027 | 390,656 | ||||||
| Property and equipment, net | 1,984 | 1,618 | ||||||
| Restricted cash | 350 | 350 | ||||||
| Right-of-use asset | 1,615 | 2,180 | ||||||
| Total assets | $ | 366,976 | $ | 394,804 | ||||
| Liabilities and stockholders equity | ||||||||
| Current liabilities: | ||||||||
| Accounts payable | $ | 1,805 | $ | 2,583 | ||||
| Accrued expenses | 12,785 | 5,278 | ||||||
| Term loan payable, net | 844 | |||||||
| Current portion of lease liability | 958 | 896 | ||||||
| Total current liabilities | 15,548 | 9,601 | ||||||
| Lease liability, net of current portion | 1,778 | 2,326 | ||||||
| Total liabilities | 17,326 | 11,927 | ||||||
| Commitments and contingencies | ||||||||
| Stockholders equity: | ||||||||
| Preferred Stock, $0.0001 par value per share; 10,000,000 shares authorized at June 30, 2021 and December 31, 2020; no shares issued and outstanding at June 30, 2021 and December 31, 2020 | ||||||||
| Common stock, $0.0001 par value per share; 200,000,000 shares authorized at June 30, 2021 and December 31, 2020, 34,998,372 and 34,801,537 shares issued, and 34,963,085 and 34,701,274 shares outstanding at June 30, 2021 and December 31, 2020, respectively | 4 | 3 | ||||||
| Additional paid-in capital | 489,743 | 479,608 | ||||||
| Accumulated deficit | (140,097 | ) | (96,734 | ) | ||||
| Total stockholders equity | 349,650 | 382,877 | ||||||
| Total liabilities, and stockholders equity | $ | 366,976 | $ | 394,804 |
Silverback Therapeutics, Inc.
Condensed Statements of Operations and Comprehensive Loss
(in thousands, except share and per share data)
| Three Months Ended June 30, | Six Months Ended June 30, | |||||||||||||||
| 2021 | 2020 | 2021 | 2020 | |||||||||||||
| Operating expenses: | ||||||||||||||||
| Research and development | $ | 17,749 | $ | 5,126 | 29,988 | $ | 9,540 | |||||||||
| General and administrative | 6,762 | 1,337 | 13,408 | 2,165 | ||||||||||||
| Total operating expenses | 24,511 | 6,463 | 43,396 | 11,705 | ||||||||||||
| Loss from operations | (24,511 | ) | (6,463 | ) | (43,396 | ) | (11,705 | ) | ||||||||
| Interest income (expense), net | 15 | (4 | ) | 33 | (41 | ) | ||||||||||
| Net loss and comprehensive loss | (24,496 | ) | (6,467 | ) | (43,363 | ) | $ | (11,746 | ) | |||||||
| Net loss per share applicable to common stockholders, basic and diluted | $ | (0.70 | ) | $ | (9.65 | ) | $ | (1.25 | ) | $ | (17.54 | ) | ||||
| Weighted-average shares used in computing net loss per share attributable to common stockholders, basic and diluted | 34,876,050 | 670,451 | 34,825,281 | 669,742 |