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This is a climate neutral print product for which carbon emissions have been calculated and offset by supporting recognised carbon offset projects. CBP035081 28268_S+N_AR25_Flat_Cover_AW_16.5mm_Spine_Bookproof_060326_Final.indd 313 06/03/2026 21:53 Life Unlimited Annual Report 2025 Annual Report 2025 www.smith-nephew.com Smith & Nephew plc Building 5, Croxley Park, Hatters Lane, Watford, Hertfordshire, WD18 8YE, United Kingdom.
The FSC label on this product ensures responsible use of the world's forest resources. Park works to the EMAS standard and its Environmental Management System is certified to ISO 14001. This publication has been manufactured using 100% offshore wind electricity sourced from UK wind. 100% of the inks used are vegetable oil based, 95% of press chemicals are recycled for further use and, on average 99% of any waste associated with this production will be recycled and the remaining 1% used to generate energy.
Please refer to the Notice of Meeting for detailed information on how to vote and submit your questions. The meeting will commence at 12:00 pm with doors opening from 11:00 am. Registered shareholders have been sent either a Notice of AGM or notification of availability of the Notice of AGM. 2026 Annual General Meeting 6 May First quarter Trading Report 6 May Payment of 2025 final dividend 27 May Half-year results announced 4 August Third quarter Trading Report 4 November Payment of 2026 interim dividend 6 November 2027 Full year results announced February Annual Report available February/March Annual General Meeting April/May 1 Dividend declaration dates. 312 Smith+Nephew Annual Report 2025 28_SN_AR25_Info_Share_P301_P312.indd 312 06/03/2026 21:50 This report was printed by Park Communications, a certified carbon neutral print company, on Magno Satin an FSC certified paper.
Wounds International 12(1): 48 53. 2 Moore Z, et al. Wounds International. 2022;13(2):32 38. 3 Smith+Nephew 2023. S+N video. 2023. 39451. Smith+Nephew Annual Report 2025 311 STRATEGIC REPORT GOVERNANCE ACCOUNTS OTHER INFORMATION 28_SN_AR25_Info_Share_v130.indd 311 05/03/2026 17:41 Financial calendar Annual General Meeting The Company's Annual General Meeting (AGM) will be held on Wednesday, 6 May 2026 at 12:00 pm at Smith+Nephew Academy London, Building 5, Croxley Park, Hatters Lane, Watford, Hertfordshire, WD18 8YE.
This device is derived from a porcine source and should not be used in patients with known sensitivity to porcine materials. This device is not indicated for use in third degree burns. References from Case Studies (pages 53-57) 1 Moore Z, Coggins T (2021) Clinician attitudes to shared-care and perceptions on the current extent of patient engagement in wound care: Results of a clinician survey.
Poster presented at: Patient Handling and Mobility Annual Conference; March 5 March 7, 2019; Orlando, Florida, USA. 72 Atkinson L, Costa B. Pressure injury prevention with a unique multi-layer foam dressing: a systematic review and meta-analysis of randomized controlled trials. Poster presented at: European Wound Management Association (EWMA); May 1 3, 2024; London, UK. * Based on ALLEVYN Dressings actual sales in 2023 and shipment of product to our primary distribution warehouses. ** Compared to baseline trajectory, n=52 wounds; p=0.006. *** Compared to standard of care. **** Compared to sharp debridement. ***** OASIS is a trademark of Cook Biotech Incorporated.
Poster presented at: Symposium on Advanced Wound Care Fall 2022; October 14 16 2022; Las Vegas, NV, USA. 70 Stone A. Preventing Pressure Injuries in Nursing Home Residents Using a Low-Profile Alternating Pressure Overlay: A Point-of-Care Trial. Adv Skin Wound Care. 2020;33(10):533-9. 71 Klaeb M, Krafft K, Walters B, Lowe J, Cooley A. The Influence of Wearable Technology on Nursing Attitudes and Adherence to Patient Turning and Repositioning.
Int Wound J. 2020; 1 11. 67 Delarmente BA. The national cost of hospital-acquired pressure injuries in the United States. Int Wound J. 2019;16(3):634-640. 68 Orlova A, Orlov, Gefen A. The protective efficacy of a new soft silicone multi-layer dressing in reducing the heel pressure ulcer risk. Int Wound J. 2025;22(10): e70764. 69 Nherera L. Meta-analysis shows patient wearable sensor reduces incidence of hospital acquired pressure injuries in critically ill patients.
Internal Report. 65 Marche C, Creehan S, Gefen A. The frictional energy absorber effectiveness and its impact on the pressure ulcer prevention performance of multilayer dressings. Int Wound J. 2024;21(4):e14871. 66 Wassel C, Delhougne G, Gayle J et al. Risk of readmissions, mortality, and hospital-acquired conditions across hospital-acquired pressure injury (HAPI) stages in a US National Hospital discharge database.
International Wound Journal. 2005;2(4): 307-314. 62 Murray F. Paper presented at: European Wound Management Association (EWMA); 2007; Glasgow. 63 Granick MS, Jacoby M, Noruthrun S, et al. Clinical and economic impact of hydrosurgical debridement on chronic wounds. Wounds. 2006;18(2):35-39. 64 Smith + Nephew 2005. The use of VERSAJET in the limb salvage following failure of minor amputation in diabetic foot.
Efficacy and cost-effectiveness of a high-powered parallel waterjet for wound debridement. Wound Repair and Regeneration. 2006 Jul-Aug;14(4):394-397. 60 Mosti G, Mattaliano V. The debridement of chronic leg ulcers by means of a new, fluidjet-based device. Wounds. 2006;18(8):227-237. 61 Mosti G, Iabichella ML, Picerni P, et al. The debridement of hard to heal leg ulcers by means of a new device based on Fluidjet technology.
The Estimation of Tissue Loss During Tangential Hydrosurgical Debridement. Annals Plast Surg. 2012;69(5):521-525. 58 Caputo WJ, Beggs DJ, DeFede JL, et al. A prospective randomised controlled clinical trial comparing hydrosurgery debridement with conventional surgical debridement in lower extremity ulcers. International Wound Journal. 2008;5(2):288-294. 59 Granick MS, Posnett J, Jacoby M, et al.
Prospective, randomised controlled trial comparing Versajet hydrosurgery and conventional debridement of partial thickness paediatric burns. Burns. 2015;41(4):700-707. 56 Rees-Lee JE, Burge T. The indication for Versajet hydrosurgical debridement in burns. European Journal of Plastic Surgery. 2008;31(4):165-170. 57 Matsumura H, Nozaki M, Watanabe K, et al.
Internal Report. CSD. AWM.22.068 310 Smith+Nephew Annual Report 2025 References from business unit sections continued Other information continued 28_SN_AR25_Info_Share_v130.indd 310 05/03/2026 17:41 54 Rennekampff HA, Schaller H-E, Wisser D, et al. Debridement of burn wounds with a water jetsurgical tool. Burns. 2006 Feb;32(1):64 - 69. 55 Hyland EJ, D'Cruz R, Menon S, et al.
Internal Report. CSD. AWM.22.071. 51 Smith+Nephew 2022. Summary of footprint, portability, wearability, weight and audible noise for the RENASYS EDGE system. Internal Report. CSD.AWM.22.067. 52 Smith+Nephew 2022. Summary of RENASYS EDGE pump mechanical and electronic reliability testing. Internal Report. CSD.AWM.22.069. 53 Smith+Nephew 2022. Summary of RENASYS EDGE pump cleaning, self-test and maintenance.
Paper presented at: EWMA; 2018; Krakow, Poland. 49 Forlee M, Richardson J, Rossington A, Cockwill J, Smith J. An interim analysis of device functionality and usability of RENASYS TOUCH a new portable Negative Pressure Wound Therapy (NPWT) system. Paper presented at: Wounds UK; 2016; Harrogate, UK. 50 Smith+Nephew 2022. RENASYS EDGE System Human Factors Summative Report Summary.
Ostomy Wound Manage. 2014;60(3):30-36. 46 Smith & Nephew 2018. PICO 14 Pump weight and dimensions. Internal report. RD/18/137. 47 Smith & Nephew March 2018. Kendal PICO 7Y pump eight and dimensions. Internal report. DS.18.066.R. 48 Forlee M, van Zyl L, Louw V, Nel J, Fourie N, Hartley R. A randomised controlled trial to compare the clinical efficacy and acceptability of adjustable intermittent and continuous Negative Pressure Wound Therapy (NPWT) in a new portable NPWT system.
BJS Open. 2021;0(0):1 8. 44 Gilchrist B, Robinson M, Jaimes H. Performance, safety, and efficacy of a single use negative pressure wound therapy system for surgically closed incision sites and skin grafts: A prospective multi-centre follow-up study. Paper presented at: SAWC; 2020; Virtual. 45 Hurd T, Trueman P, Rossington A. Use of a portable, single-use negative pressure wound therapy device in home care patients with low to moderately exuding wounds: A case series.
Paper presented at: EWMA; 2019; Gothenburg, Sweden. 42 Dowsett C, Hampton K, Myers D, Styche T. Use of PICO to improve clinical and economic outcomes in hard-to-heal wounds. Wounds International. 2017;8(2):52-58. 43 Saunders C, Nherera LM, Horner A, Trueman P. Single-Use negative-pressure wound therapy versus conventional dressings for closed surgical incisions: systematic literature review and meta-analysis.
Internal Report. EO. AWM.PCS230.001.v2. 40 Loveluck J, Copeland, T., Hill, J., Hunt, A., and Martin, R., . Biomechanical Modeling of the Forces Applied to Closed Incisions During Single-Use Negative Pressure Wound Therapy. ePlasty. 2016;16:183-195. 41 Casey C. Consistent delivery of therapeutic negative pressure levels by a single use negative pressure wound therapy system (sNPWT)* in a wound model.
Report: AWM.24.065 37 Smith+Nephew July 2018.PICO 7Y Non-NPWT Wound Model Summary. Internal Report. DS.18.260.R. 38 Hurd T, Gilchrist B. Single use negative pressure wound therapy (sNPWT) in the community management of chronic open wounds deeper than 2cm. Paper presented at: Symposium on Advanced Wound Care/Wound Healing Society Meeting; 2020; Abu Dhabi. 39 Smith+Nephew November 2018.The Review Of Evidence Supporting The Use Of PICO In Wounds 2cm In Depth.
Ostomy Wound Manage. 2017 Dec;63(12): 38-47. 35 Smith+Nephew 2020. Bacterial barrier testing of the PICO dressing. Internal Report. 2001002. 36 Smith+Nephew 2024. Assessment of the Effect of the PICO 7 Single Use Negative Pressure Wound Therapy System and Conventional Dressings on Pre-Established Biofilms in vitro Using a Wound Surface Biofilm Model.
Int Wound J. 2014 Oct; 11(5): 554 560. 33 McGinness K, Kurtz Phelan DH. Use of Viable Cryopreserved Umbilical Tissue for Soft Tissue Defects in Patients with Gas Gangrene: A Case Series. Wounds. 2018 Apr; 30(4): 90 95. 34 Nherera LM, Romanelli M, Trueman MA, et al. An Overview of Clinical and Health Economic Evidence Regarding Porcine Small Intestine Submucosa Extracellular Matrix in the Management of Chronic Wounds and Burns.
Int Wound J. 2010; 7: 87-95. 31 Sheets AR, Demidova-Rice TN, Shi L, Ronfard V, Grover KV, Herman IM (2016) Identification and Characterization of Novel Matrix-Derived Bioactive Peptides: A Role for Collagenase from Santyl Ointment in Post-Debridement Wound Healing? PLoS ONE 11(7): e0159598. 32 Lavery LA, Fulmer J, Shebetka KA, et al. The efficacy and safety of Grafix for the treatment of chronic diabetic foot ulcers: results of a multi-centre, controlled, randomised, blinded clinical trial.
DOF 0703007. 28 Herman, I. Stimulation of human keratinocyte migration and proliferation in vitro: insights into the cellular responses to injury and wound healing. Wounds. 1996; 8:33-40. 29 Riley et al. Collagenase promotes the cellular responses to injury and wound healing in vivo. J Burns Wounds. 2005; 4:112-124. 30 Shi et al. Degradation of human collagen isoforms by Clostridium collagenase and the effects of degradation products on cell migration.
DOF 0707052. 25 Smith+Nephew 2008. A multi-centre in-market evaluation of ALLEVYN Ag dressings. Internal Report. SR/CIME/009. 26 Smith+Nephew 2018. PMCF Research for Allevyn Ag Adhesive. Internal Report. PMS-273-01. 27 Smith+Nephew 2007. Antimicrobial Activity of ALLEVYN Ag Adhesive Dressing Against a Broad Spectrum of Microorganisms. Internal Report.
Int Wound J. 2019;16(3):674 83. 23 Smith+Nephew 2007. Antimicrobial Activity of Allevyn Ag Non-Adhesive Dressing against a Broad Spectrum of Microorganisms. Internal Report. DOF 0703006. 24 Smith+Nephew 2007. Antimicrobial activity of ALLEVYN Ag dressings against a broad spectrum of wound pathogens using a dynamic shake flask method. Internal Report.
British Journal of Dermatology. 1983;109:77 83. 21 Fitzgerald DJ, Renick PJ, Forrest EM, et al. Cadexomer iodine provides superior efficacy against bacterial wound biofilms in vitro and in vivo. Wound Repair Regen. 2017;25(1):13 24. 22 Roche ED, Woodmansey EJ, Yang Q, et al. Cadexomer iodine effectively reduces bacterial biofilm in porcine wounds ex vivo and in vivo.
Cost-effectiveness analysis of single-use negative pressure wound therapy dressings (sNPWT) to reduce surgical site complications (SSC) in routine primary hip and knee replacements. Wound Repair Regen. 2017;25(4):474-482. 19 Smith+Nephew. Internal Report. RR-WMP07330-10-03. 20 Skog E et al. A randomised trial comparing cadexomer iodine and standard treatment in the out-patient management of chronic venous ulcers.
Wounds UK. 2014;10(3):80 87. 14 S+N Data on File. Wound Model Testing of New ALLEVYN Life Gen2wcl Dressing using Horse Serum at a Flow Rate Modelling that of a Moderately Exuding Wound. DS/14/303/R. 2016. 15 Smith+Nephew 2021. Internal Report. EA/AWM/ ALLEVYN/001v4. 16 SmartTrak Report, 2022. 17 Smith+Nephew. Internal Report. 151008. 18 Nherera LM, Trueman P, Karlakki.
Wounds UK. 2013;9(4):91 95. 11 S+N Data on File. Odour reducing properties of ALLEVYN LIFE. Internal Report. DS/12/127/DOF. 2012. 12 Tiscar-Gonz lez V, Menor-Rodr guez MJ, Rabad n-Sainz C, et al. Clinical and Economic Impact of Wound Care Using a Polyurethane Foam Multilayer Dressing. Adv Skin Wound Care. 2021;34(1):23-30. 13 Simon D, Bielby A.A structured collaborative approach to appraise the clinical performance of a new product.
Clinical and Economic Impact of Wound Care Using a Polyurethane Foam Multilayer Dressing. Adv Skin Wound Care. 2021;34(1):23-30. 9 Simon D, Bielby A. A structured collaborative approach to appraise the clinical performance of a new product. Wounds UK. 2014;10(3):80 878. 10 Rossington A, Drysdale K, Winter R. Clinical performance and positive impact on patient wellbeing of ALLEVYN Life.
Wounds UK. 2013;9(4):91 95. Smith+Nephew Annual Report 2025 309 STRATEGIC REPORT GOVERNANCE ACCOUNTS OTHER INFORMATION 28_SN_AR25_Info_Share_v130.indd 309 05/03/2026 17:41 7 White, R., Hartwell, S., and Brown,S., Interim report on a study to assess the effectiveness and improved fluid uptake of new ALLEVYN. Wounds UK. 2007; 3(4):122-127 Available here: https://www.woundsinternational.com/ resources/ details/interim-report-on-the-study-to-assess-the- effectiveness-and-improvedfluid-uptake-of-new-allevyn. 8 Tiscar-Gonz lez V, Menor-Rodr guez MJ, Rabad n-Sainz C, et al.
CSD.AWM.22.050. 4 Hurd T, Gregory L, Jones A, Brown S.A multi-centre in-market evaluation of ALLEVYN Gentle Border. Wounds UK. 2009;5(3):32-44. 5 Leonard S, Mccluskey P, Long S, et al. An evaluation of Allevyn Adhesive and Non Adhesive foam dressings. Wounds UK. 2009;5(1):17-28. 6 Rossington A, Drysdale K, Winter R. Clinical performance and positive impact on patient wellbeing of ALLEVYN Life.
Body text 1 Smith+Nephew 2024. Methodology for calculating the reduction in global packaging material and Greenhouse Gas (GHG) emissions of ALLEVYN Dressings. CSD.AWM.24.017. 2 Smith+Nephew 2024. Methodology for calculating the reduction in global packaging material of RENASYS - G Gauze Dressing kit with Softport. CSD.AWM.24.077. 3 Smith+Nephew 2022.Post Market Clinical Follow-Up (PMCF) Report for ALLEVYN GENTLE.
Negative pressure wound therapy for surgical wounds healing by primary closure (Review). Cochrane Database of Syst Rev. 2020;5(CD009261):1-263. 2 Saunders C, Nherera LM, Horner A, Trueman P. Single-Use negative-pressure wound therapy versus conventional dressings for closed surgical incisions: systematic literature review and meta-analysis. BJS Open. 2021;0(0):1 - 8.
REGENETEN Bone Anchors are only indicated for use in rotator cuff repair. Published clinical outcomes are for rotator cuff. The REGENETEN Implant is currently approved for use in treating Gluteus Medius and Achilles tears only in the US. As compared to mechanical debridement for knee chondroplasty; n=60; p<0.001. References from Advanced Wound Management (pages 49-52) PICO pullout 1 Norman G, Goh EL, Dumville JC, et al.
Testing performed in 2025. At the 48-month follow-up, 1.2% (n=2) of patients in the scaffold group and 9.5% (n=8) of patients in the control group (microfracture or debridement) had undergone a knee replacement or osteotomy (p=0.003). The REGENETEN Implant is cleared for use on any tendon where there is not substantial loss of tendon tissue. The REGENETEN Implant is cleared for use on any tendon where there is not substantial loss of tendon tissue.
Clinical Otolaryngology. 2005;30:333-337. 72 Moumoulidis I, Draper MR, Patel H, Jani P, Price T. A prospective randomised controlled trial comparing Merocel and Rapid Rhino nasal tampons in the treatment of epistaxis. Eur Arch Otorhinolaryngol. 2006;263(8):719-722. *Demonstrated clinically and in-vivo. ** As compared to competitive devices in fixation/ pull-out benchtop testing. *** As demonstrated in benchtop testing. **** As compared to the competitive device in cyclic benchtop testing. ***** Compared to traditional #2 suture.
Laryngoscope. 2020;130:S1 S9, 2020. 69 IFU007011, available at www.tulatubes.com/IFU. 70 Singer AJ, Blanda M, Cronin K, et al. Comparison of nasal tampons for the treatment of epistaxis in the emergency department: a randomized controlled trial. Ann Emerg Med. 2005;45(2):134-9. 71 Badran K, Malik TH, Belloso A, Timms MS. Randomized controlled trial comparing MerocelTM and Rapid-RhinoTM packing in the management of anterior epistaxis.
Intracapsular Tonsillectomy Using Plasma Ablation Versus Total Tonsillectomy: A Systematic Literature Review and Meta-Analysis. OTO open. 2023;7(1):e22. 67 Smith+Nephew 2023.ARIS Targeted Hemostasis. Internal Memo. 10094398 Rev A. 68 Lustig LR, Ingram A, Vidrine M, et. al. In-Office Tympanostomy Tube Placement in Children Using Iontophoresis and Automated Tube Delivery.
Coblation tonsillectomy: A prospective, double-blind, randomised, clinical and histopathological comparison with dissection-ligation, monopolar electrocautery and laser tonsillectomies. J Laryngol Otol. 2008;122:282 290. 65 Smith+Nephew 2019. HALO and PROCISE XP Peak Electrode Temperature, ENC053. P/N 108740 Rev. A. 66 Sedgwick MJ, Saunders C, Bateman N.
Coll Antropol. 2009;33:293 298. 62 Smith+Nephew 2010. PROCISE LW & MLW, Thermal Measurement and Comparison to CO2 and KTP Laser Systems. Internal Report. P/N 86257 Rev. A. 63 Smith+Nephew 2010. PROcise XP Comparative Thermal Measurement Bench-Top Study. Internal Report. P/N 60736 01 Rev. A. 64 Magdy EA, Elwany S, El-Daly AS, Abdel-Hadi M, Morshedy MA.
Temperature Study PEAK 60 Smith+Nephew 2010. EVac 70 Xtra Comparative Thermal Measurement Bench-Top Study. Internal Report. P/N 60735-01 Rev. A. 61 Roje Z, Racic G, Dogas Z, Pesuti Pisac V, Timms M. Postoperative morbidity and histopathologic characteristics of tonsillar tissue following coblation tonsillectomy in children: A prospective randomized single-blind study.
Knee Surg Sports Traumatol Arthrosc.2008;16(6):565 573. 57 Smith+Nephew 2021.Protocol, Claims, PLATINUM MDU- Torque. Internal Report. 15011440 Rev A. 58 Smith+Nephew 2017. Coblation Dissection Versus Monopolar Dissection A Systematic Review and Meta-analysis P/N 91999 Rev. A. 59 Temple RH, Timms MS. Paediatric coblation tonsillectomy. Int J Pediatr Otorhinolaryngol. 2001;61(3):195 198. 51 Smith+Nephew 2010.
ANAKIN Expected Life Summary Report. Internal Report. 15011066 Rev A. 54 TUV Rheinland 2022. SNE LENS 4K 60601-1 Report. Internal Report. 31892667.001. 55 ArthoCare 2014. Comparative Performance of the FLOW50 Wand and the Predicate Wands in Tissue Models. P/N 52918-01. 56 Spahn G, Kahl E, Muckley T, Hofmann GO, Klinger HM. Arthroscopic knee chondroplasty using a bipolar radiofrequency-based device compared to mechanical shaver: results of a prospective, randomized, controlled study.
Internal Report. 15012288 Rev A. 50 Smith+Nephew 2023. Competitive Claims, Q-FIX with Needles, Fixation Report. Internal Report. 10093596 Rev A. 51 Smith+Nephew 2022. ANAKIN Shock and Vibration (Advantech Test Report). Internal Report. 15011068 Rev A. 52 Smith+Nephew 2022. INTELLIO 4K CCU Environmental Testing. Internal Report. 15010785 Rev A. 53 Smith+Nephew 2022.
Int Orthop. 2024;48(12):3117-3126 47 U.S. Food & Drug Administration. K242631. https://www.accessdata.fda.gov/cdrh_docs/ pdf24/K242631.pdf 48 Smith+Nephew 2023. Verif, Q-FIX with Needles Hard Bone Insertion, Fixation, and Cyclic. Internal Report. 15012313 Rev A. 49 Smith+Nephew 2023. Verif, Q-FIX with Needles Fixation (12pcf, 25/5pcf), Needle Attachment Strength, and Knot Tensile Strength Testing.
Injury. 2016;47 Suppl 6:S27-S32. 45 Kon E, Filardo G, Shani J, et al. Osteochondral regeneration with a novel aragonite-hyaluronate biphasic scaffold: up to 12-month follow-up study in a goat model. J Orthop Surg Res. 2015;10:81. 46 Conte P, Anzillotti G, Crawford DC, et al. Differential analysis of the impact of lesions' location on clinical and radiological outcomes after the implantation of a novel aragonite-based scaffold to treat knee cartilage defects.
Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions in Mild to Moderate Osteoarthritic Knees: Results of a 2-Year Multicenter Prospective Study. Am J Sports Med.2021;49(3):588-598. 44 Kon E, Robinson D, Verdonk P, et al. A novel aragonite-based scaffold for osteochondral regeneration: early experience on human implants and technical developments.
ITR-2928. Rev E 41 Smith+Nephew 2021. Internal report. 15010267 Rev A. 42 Altschuler N, Zaslav KR, Di Matteo B, et al. Aragonite-Based Scaffold Versus Microfracture and Debridement for the Treatment of Knee Chondral and Osteochondral Lesions: Results of a Multicenter Randomized Controlled Trial. Am J Sports Med. 2023;51(4):957-967. 308 Smith+Nephew Annual Report 2025 References from business unit sections continued Other information continued 28_SN_AR25_Info_Share_v130.indd 308 05/03/2026 17:41 43 Kon E, Di Matteo B, Verdonk P, et al.
P/N 10144423B. 37 Smith+Nephew 2020. Safety and Performance of Q-Fix All-Suture Anchor System. Internal Report. 17-5010-11. 38 Smith+Nephew 2016.Feasibility, MINITAPE Knot Stack Evaluation and Knot Security.15005268. Rev A 39 Smith+Nephew 2013.ULTRATAPE Pressure Film Testing. 15001847. Rev A. 40 Smith+Nephew 2006.USP Knot Strength, ULTRABRAID (white).
Mechanical properties of all-suture anchors for rotator cuff repair. Bone Joint Res. 2017;6(2):82-89. 35 Ruder JA, Dickinson EY, Peindl RD, Habet NA, Trofa DP, Fleischli JE. Cyclic and Load-to-Failure Properties of All-Suture Anchors in Human Cadaveric Shoulder Glenoid Bone. Arthroscopy. 2019;35(7):1954-1959 e1954. 36 ArthroCare Corporation 2017. Report: Design Verification, 1.8mm Q-FIX MINI Soft Suture Anchor.
Am J Sports Med. 2017;45(7):1622-1626. 32 ArthroCare 2019. Comparative Testing of Bone Anchor Devices, 1.8mm Q-FIX Mini Soft Suture Anchor P/N 49193-02 Rev.B. 33 Barber FA, Herbert MA. All-Suture Anchors: Biomechanical Analysis of Pullout Strength, Displacement, and Failure Mode. Arthroscopy. 2017;33(6):1113-1121. 34 Nagra NS, Zargar N, Smith RD, Carr AJ.
B. 30 Bernardoni E, Frank RM, Veera SS, et al. Biomechanical Analysis of All-Suture Anchor Fixation for Rotator Cuff Repair. Orthop J Sports Med. 2018;6(7 suppl4). 31 Saper MG, Meijer K, Winnier S, Popovich J, Jr., Andrews JR, Roth C. Biomechanical Evaluation of Classic Solid and All-Soft Suture Anchors for Medial Patellofemoral Ligament Reconstruction.
Internal Report. 10090792- Revision B. 27 ArthroCare Corporation 2017. Report: Design Verification, 1.8mm Q-FIX MINI Soft Suture Anchor. P/N 10144423B. 28 Ergun S, Akgun U, Barber A, Karahan M. The Clinical and Biomechanical Performance of All-Suture Anchors: A Systematic Review. Arthroscopy. 2020; 2(3): e263-e275. 29 ArthroCare Corporation 2017. Report: Design Verification, 1.8mm Q-FIX MINI Soft Suture Anchor P/N 49190-03 Rev.
Healicoil Regenesorb Suture Anchor a study to assess implant replacement by bone over a 2 year period. NCS248. 25 Douglass NP, Behn AW, Safran MR. Cyclic and Load to Failure Properties of All-Suture Anchors in Synthetic Acetabular and Glenoid Cancellous Bone. Arthroscopy. 2017;33(5):977-985 e975. 26 Smith and Nephew 2023. Q-FIX with MINITAPE Claims Report.
Osteoconductive resorption characteristics of a novel biocomposite suture anchor material in rotator cuff repair. Orthop Traumatol Surg Res. 2019;14(1):12. 23 Smith+Nephew 2010. Micro-CT and histological evaluation of specimens from resorbable screw study (RS-II/OM1-08) 24-month post-implantation. Internal Report WRP-TE045-700-08. 24 Smith+Nephew 2016.
An isolated bioinductive repair vs sutured repair for full-thickness rotator cuff tears: 2-year results of a double blinded, randomized controlled trial. J Shoulder Elbow Surg. 2024;33(9):1894-1904. 21 American Academy of Orthopedic Surgeons (AAOS). Rotator Cuff Repair Clinical Practice Guideline. Available at: https://www.aaos.org/ quality/quality-programs/clinical-practice-guidelines/ (Accessed January 2026) 22 Vonhoegen J, John D, H germann C.
Arthrosc Sports Med Rehabil. 2021 Aug 20;3(5):e1473 e1479. 19 Bushnell BD, Bishai SK, Krupp RJ, McMillan S, Schofield BA, Trenhaile SW, McIntyre LF. Treatment of Partial-Thickness Rotator Cuff Tears With a Resorbable Bioinductive Bovine Collagen Implant: 1-Year Results From a Prospective Multicenter Registry. Orthop J Sports Med. 2021 Aug 13;9(8). 20 Camacho Chac n JA, Roda Rojo V, Martin Martinez A, et al.
Muscles, Ligaments Tendons J. 2019;9(3):338 347. 17 McElvany MD, McGoldrick E, Gee AO, Neradilek MB, Matsen FA, 3rd. Rotator cuff repair: published evidence on factors associated with repair integrity and clinical outcome. Am J Sports Med. 2015;43(2):491 500. 18 McIntyre LF, McMillan S, Trenhaile SW, Bishai SK, Bushnell BD. Full-Thickness Rotator Cuff Tears Can Be Safely Treated With Resorbable Bioinductive Bovine Collagen Implant: One-Year Results of a Prospective, Multicenter Registry.
Muscles, Ligaments Tendons J 2016;6(1):16 25. 15 Schlegel TF, Abrams JS, Bushnell BD, Brock JL, Ho CP. Radiologic and clinical evaluation of a bioabsorbable collagen implant to treat partial-thickness tears: a prospective multicenter study. J Shoulder Elbow Surg. 2018 27(2):242 251. 16 Bokor DJ, Sonnabend DH, Deady L, et al. Healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a highly porous collagen implant: a 5-year clinical and MRI follow-up.
Arthroscopy. 2025;41(10):3869-3879. 13 Yoo J, Lee D. The Clinical Outcomes of a Bioinductive Collagen Implant in Bursal-Sided Partial-Thickness Rotator Cuff Tears. Medicina. 2025;61(6):988 14 Bokor DJ, Sonnabend D, Deady L, et al. Evidence of healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a collagen implant: 2-year MRI follow-up.
Acta Biomed. 2020;91(14-S):e2020004. 11 Rab P, Shirinskiy IJ, Kimmeyer M, et al. Augmentation of full-thickness rotator cuff tears with a bioinductive collagen implant does not reduce retear rates a propensity matched cohort study. BMC Musculoskeletal Disorders. 2025;26(1):855. 12 Ruiz Iban MA, Garcia Navlet M, Moros Marco S, et al. Augmentation of a Posterosuperior Cuff Repair With a Bovine Bioinductive Collagen Implant Shows a Lower Retear Rate but Similar Outcomes Compared With No Augmentation: 2-Year Results of a Randomized Controlled Trial.
Clin Orthop Relat Res. 2025;483(3):442-452. 9 Kinjo H, Suenaga N, Oizumi N, Nishida K. Safety of bioinductive bovine collagen implants for arthroscopic rotator cuff repair. JSES International. 2025;9(4):1177-1182. 10 Micheloni GM, Salmaso G, Zecchinato G, Giaretta S, Barison E, Momoli A. Bio-inductive implant for rotator cuff repair: our experience and technical notes.
Biological augmentation in revision surgery: effect of a bioinductive collagen patch (REGENETEN) in patients with rotator cuff retear and a previous arthroscopic rotator cuff repair. Journal of Shoulder and Elbow Surgery. 2025. 8 Haft M, Li SS, Pearson ZC, Ahiarakwe U, Bettencourt AF, Srikumaran U. No Short-term Clinical Benefit to Bovine Collagen Implant Augmentation in Primary Rotator Cuff Repair: A Matched Retrospective Study.
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We are grateful to the Healthcare Quality Improvement Partnership (HQIP), the NJR Steering Committee and staff at the NJR Centre for facilitating this work. The views expressed represent those of the authors and do not necessarily reflect those of the National Joint Registry Steering Committee or the Health Quality Improvement Partnership (HQIP) who do not vouch for how the information is presented. *** Compared to NAVIO Handheld Robotics. **** Compared to Mako and ROSA. ***** With use of handpiece.
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