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Gender Representation in Orthopaedic Surgery: A Geospatial Analysis From 2015 to 2022. References from business unit sections continued Other information continued 288 Smith+Nephew Annual Report 2024 Financial calendar Annual General Meeting The Company's Annual General Meeting ( AGM') will be held on Wednesday, 30 April 2025 at 12:00pm at Smith+Nephew Academy London, Building 5, Croxley Park, Hatters Lane, Watford, Hertfordshire, WD18 8YE.
References from Case Studies (pages 51-57) 1 Moore Z, Coggins T (2021) Clinician attitudes to shared-care and perceptions on the current extent of patient engagement in wound care: Results of a clinician survey. Wounds International 12(1): 48 53. 2 Moore Z, et al. Wounds International. 2022;13(2):32 38. 3 Smith+Nephew 2023. S+N video. 2023. 39451. References from Creating a Culture to Win section (pages 58-63) 1 Peterman N, Macinnis B, Stauffer K, Mann R, Yeo E, Carpenter K.
Ostomy Wound Manage. 2014;60(3):30 36. b Data used in 2022 and 2023 estimates generated by Smith+Nephew is based on publicly available sources and internal analysis and represents an indication of market shares and sizes. * Based on ALLEVYN Dressings actual sales in 2023 and shipment of product to our primary distribution warehouses. *Compared to baseline trajectory, n=52 wounds; p=0.006. **Compared to standard of care. ***Compared to sharp debridement.
The Influence of Wearable Technology on Nursing Attitudes and Adherence to Patient Turning and Repositioning. Poster presented at: Patient Handling and Mobility Annual Conference; March 5 March 7, 2019; Orlando, Florida, USA. 59 Hurd T, Trueman P, Rossington A. Use of a Portable, Single-use Negative Pressure Wound Therapy Device in Home Care Patients with Low to Moderately Exuding Wounds: A Case Series.
Poster presented at: European Wound Management Association (EWMA); May 1 3, 2024; London, UK. 57 Agency for Healthcare Research and Quality website. Preventing pressure ulcers in hospitals: a toolkit for improving quality of care. https://www.ahrq.gov/ professionals/systems/hospital/pressureulcertoolkit/ putool1.html. Updated October 2014. Accessed February 1, 2018. 58 Klaeb M, Krafft K, Walters B, Lowe J, Cooley A.
Int Wound J. 2020; 1 11. 55 Awoke N, Tekalign T, Arba A, Lenjebo TL. Pressure injury prevention practice and associated factors among nurses at Wolaita Sodo University Teaching and Referral Hospital, South Ethiopia: a cross-sectional study. BMJ Open. 2022;12(3):e047687. 56 Atkinson L, Costa B. Pressure injury prevention with a unique multi-layer foam dressing: a systematic review and meta-analysis of randomized controlled trials.
Preventing Pressure Injuries in Nursing Home Residents Using a Low-Profile Alternating Pressure Overlay: A Point-of-Care Trial. Adv Skin Wound Care. 2020;33(10):533-9. 54 Wassel C, Delhougne G, Gayle J et al. Risk of readmissions, mortality, and hospital-acquired conditions across hospital-acquired pressure injury (HAPI) stages in a US National Hospital discharge database.
The frictional energy absorber effectiveness and its impact on the pressure ulcer prevention performance of multilayer dressings. Int Wound J. 2024;21(4):e14871. 52 Agency for Healthcare Research and Quality website. Preventing pressure ulcers in hospitals: a toolkit for improving quality of care. (PDF). Updated October 2014. Accessed October 2024. https://www.ahrq.gov/ professionals/systems/hospital/pressureulcertoolkit/ putool1.html. 53 Stone A.
International Wound Journal. 2005;2(4): 307-314. 48 Murray F. Paper presented at: European Wound Management Association (EWMA); 2007; Glasgow. 49 Granick MS, et al. WOUNDS. 2006;18(2):35-39. 50 Smith + Nephew 2005. The use of VERSAJET in the limb salvage following failure of minor amputation in diabetic foot. Internal Report. 51 Marche C, Creehan S, Gefen A.
BURNS. 2015;41(4):700-707. 42 Rees-Lee JE, et al. European Journal of Plastic Surgery. 2008;31(4):165-170. 43 Matsumura H, et al. Annals of Plastic Surgery. 2012;69(5):521-525. 44 Caputo WJ, et al. International Wound Journal. 2008;5(2):288-294. 45 Granick MS, et al. Wound Repair and Regeneration. 2006;14(4):394-397. 46 Mosti G, et al. WOUNDS. 2006;18(8):227-237. 47 Mosti G, et al.
Internal Report. CSD.AWM.22.067. 38 Smith+Nephew 2022. Summary of RENASYS EDGE pump mechanical and electronic reliability testing. Internal Report. CSD.AWM.22.069. 39 Smith+Nephew 2022. Summary of RENASYS EDGE pump cleaning, self-test and maintenance. Internal Report. CSD. AWM.22.068. 40 Rennekampff HA, et al. Burns. 2006;32(1):64 - 69. 41 Hyland EJ, et al.
An interim analysis of device functionality and usability of RENASYS TOUCH a new portable Negative Pressure Wound Therapy (NPWT) system. Paper presented at: Wounds UK; 2016; Harrogate, UK. 36 Smith+Nephew 2022. RENASYS EDGE System Human Factors Summative Report Summary. Internal Report. CSD. AWM.22.071. 37 Smith+Nephew 2022. Summary of footprint, portability, wearability, weight and audible noise for the RENASYS EDGE system.
Paper presented at: SAWC; 2020; Virtual. 34 Forlee M, van Zyl L, Louw V, Nel J, Fourie N, Hartley R. A randomised controlled trial to compare the clinical efficacy and acceptability of adjustable intermittent and continuous Negative Pressure Wound Therapy (NPWT) in a new portable NPWT system. Paper presented at: EWMA; 2018; Krakow, Poland. Smith+Nephew Annual Report 2024 287 STRATEGIC REPORT GOVERNANCE ACCOUNTS OTHER INFORMATION 35 Forlee M, Richardson J, Rossington A, Cockwill J, Smith J.
Single-Use negative-pressure wound therapy versus conventional dressings for closed surgical incisions: systematic literature review and meta-analysis. BJS Open. 2021;0(0):1 8. 33 Gilchrist B, Robinson M, Jaimes H. Performance, safety, and efficacy of a single use negative pressure wound therapy system for surgically closed incision sites and skin grafts: A prospective multi-centre follow-up study.
DOF 0703007. 28 Lavery et al. Int Wound J. 2014; 11(5): 554 560. 29 McGinness K, Kurtz Phelan DH. Wounds. 2018; 30(4): 90 95. 30 Nherera et al. Ostomy Wound Manage. 2017;63(12):38 47. 31 Dowsett C, Hampton K, Myers D, Styche T. Use of PICO to improve clinical and economic outcomes in hard-to-heal wounds. Wounds International. 2017;8(2):5258. 32 Saunders C, Nherera LM, Horner A, Trueman P.
DOF 0707052. 25 Smith+Nephew 2008. A multi-centre in-market evaluation of ALLEVYN Ag dressings. Internal Report. SR/CIME/009. 26 Smith+Nephew 2018. PMCF Research for Allevyn Ag Adhesive. Internal Report. PMS-273-01. 27 Smith+Nephew 2007. Antimicrobial Activity of ALLEVYN Ag Adhesive Dressing Against a Broad Spectrum of Microorganisms. Internal Report.
Int Wound J. 2019;16(3):674 83. 23 Smith+Nephew 2007. Antimicrobial Activity of Allevyn Ag Non-Adhesive Dressing against a Broad Spectrum of Microorganisms. Internal Report. DOF 0703006. 24 Smith+Nephew 2007. Antimicrobial activity of ALLEVYN Ag dressings against a broad spectrum of wound pathogens using a dynamic shake flask method. Internal Report.
Wound Repair Regen. 2017;25(4):707 721. 19 Smith+Nephew. Internal Report. RR-WMP07330-10-03. 20 Skog E et al. British Journal of Dermatology. 1983;109:77 83. 21 Fitzgerald DJ et al. Wound Repair Regen. 2016;25(1):13 24. 22 Roche ED, Woodmansey EJ, Yang Q, et al. Cadexomer iodine effectively reduces bacterial biofilm in porcine wounds ex vivo and in vivo.
Wounds UK. 2014;10(3):80 87. 14 S+N Data on File. Wound Model Testing of New ALLEVYN Life Gen2wcl Dressing using Horse Serum at a Flow Rate Modelling that of a Moderately Exuding Wound. DS/14/303/R. 2016. 15 Smith+Nephew 2021. Internal Report. EA/AWM/ ALLEVYN/001v4. 16 SmartTrak Report, 2022. 17 Smith+Nephew. Internal Report. 151008. 18 Nherera LM et al.
Wounds UK. 2013;9(4):91 95. 11 S+N Data on File. Odour reducing properties of ALLEVYN LIFE. Internal Report. DS/12/127/DOF. 2012. 12 Tiscar-Gonz lez V, Menor-Rodr guez MJ, Rabad n-Sainz C, et al. Clinical and Economic Impact of Wound Care Using a Polyurethane Foam Multilayer Dressing. Adv Skin Wound Care. 2021;34(1):23-30. 13 Simon D, Bielby A.A structured collaborative approach to appraise the clinical performance of a new product.
Clinical and Economic Impact of Wound Care Using a Polyurethane Foam Multilayer Dressing. Adv Skin Wound Care. 2021;34(1):23-30. 9 Simon D, Bielby A. A structured collaborative approach to appraise the clinical performance of a new product. Wounds UK. 2014;10(3):80 878. 10 Rossington A, Drysdale K, Winter R. Clinical performance and positive impact on patient wellbeing of ALLEVYN Life.
Wounds UK. 2009;5(1):17-28. 6 Rossington A, Drysdale K, Winter R. Clinical performance and positive impact on patient wellbeing of ALLEVYN Life. Wounds UK. 2013;9(4):91 95. 7 White, R., Hartwell, S., and Brown,S., Interim report on a study to assess the effectiveness and improved fluid uptake of new ALLEVYN. Wounds UK. 2007; 3(4):122-127 Available here: https://www.woundsinternational.com/resources/ details/interim-report-on-the-study-to-assess-the-effectiveness-and-improvedfluid-uptake-of-new-allevyn. 8 Tiscar-Gonz lez V, Menor-Rodr guez MJ, Rabad n-Sainz C, et al.
CSD.AWM.24.077. 3 Smith+Nephew 2022.Post Market Clinical Follow-Up (PMCF) Report for ALLEVYN GENTLE. CSD.AWM.22.050. 4 Hurd T, Gregory L, Jones A, Brown S.A multi-centre in-market evaluation of ALLEVYN Gentle Border. Wounds UK. 2009;5(3):32-44. 5 Leonard S, Mccluskey P, Long S, et al. An evaluation of Allevyn Adhesive and Non-Adhesive foam dressings.
Versus microfracture debridement. References from Advanced Wound Management (pages 47-50) 1 Smith+Nephew 2024. Methodology for calculating the reduction in global packaging material and Greenhouse Gas (GHG) emissions of ALLEVYN Dressings. CSD.AWM.24.017. 2 Smith+Nephew 2024. Methodology for calculating the reduction in global packaging material of RENASYS - G Gauze Dressing kit with Softport.
REGENETEN Bone Anchors are only indicated for use in rotator cuff repair. Published clinical outcomes are for rotator cuff. The REGENETEN Implant is currently approved for use in treating Gluteus Medius and Achilles tears only in the US. as demonstrated in benchtop testing. as demonstrated ex-vivo. As compared to mechanical debridement for knee chondroplasty; n=60; p<0.001. over 2 and 4 year follow up.
Differential analysis of the impact of lesions' location on clinical and radiological outcomes after the implantation of a novel aragonite-based scaffold to treat knee cartilage defects. Int Orthop. 2024;48(12):3117-3126. a These non-IFRS financial measures are explained and reconciled to the most directly comparable financial measure prepared in accordance with IFRS on pages 265-271. b Data used in 2022 and 2023 estimates generated by Smith+Nephew is based on publicly available sources and internal analysis and represents an indication of market shares and sizes. c Representing repair products and arthroscopic enabling technologies, and excluding ENT. d A division of Johnson & Johnson. *Demonstrated clinically and in-vivo. **compared to traditional #2 suture. ***as compared to the competitive device in cyclic benchtop testing. **** The REGENETEN Implant is cleared for use on any tendon where there is not substantial loss of tendon tissue.
The use of osteoconductive bone graft substitutes in orthopaedic trauma. J Am Acad Orthop. 74 Surg. 2007;15(9):525-536. 75 Allison DC, Lindberg AW, Mirzayan R, Samimi B, Menendez LR. A Comparison of Mineral Bone Graft Substitutes for Bone Defects. US Oncology and Hematolog. 2011. 76 Costantino PD, Friedman CD. Synthetic bone graft substitutes. Otolaryngol Clin North Am. 1994;27(5):1037- 74. 77 Conte P, Anzillotti G, Crawford DC, et al.
Clinical Otolaryngology. 2005;30:333-337. 71 Moumoulidis I, Draper MR, Patel H, Jani P, Price T. A prospective randomised controlled trial comparing Merocel and Rapid Rhino nasal tampons in the treatment of epistaxis. Eur Arch Otorhinolaryngol. 2006;263(8):719-722. 72 Smith+Nephew 2020 REGENETEN Collagen Implant Physical Characteristics. Internal Report. 15009769. 73 Hak DJ.
P/N 10144423B. 69 Kon E, Filardo G, Robinson D, et al. Osteochondral regeneration using a novel aragonite-hyaluronate bi-phasic scaffold in a goat model. Knee Surg Sports Traumatol Arthrosc. 2014;22(6):1452-1464. 70 Badran K, Malik TH, Belloso A, Timms MS. Randomized controlled trial comparing MerocelTM and Rapid-RhinoTM packing in the management of anterior epistaxis.
J Orthop Surg Res. 2015;10:81. 66 de Caro F, Vuylsteke K, Van Genechten W, Verdonk P. Acellular Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions of the Knee: A Minimum 5-Year Follow-Up Study. Cartilage. 2024;15(4):399-406. 67 CartiHeal 2009. Indications for Use: Agili-C implant. 68 ArthroCare Corporation 2017. Report: Design Verification, 1.8mm Q-FIX MINI Soft Suture Anchor.
Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions in Mild to Moderate Osteoarthritic Knees: Results of a 2-Year Multicenter Prospective Study. Am J Sports Med. 2021;49(3):588-598. 65 Kon E, Filardo G, Shani J, et al. Osteochondral regeneration with a novel aragonite-hyaluronate biphasic scaffold: up to 12-month follow-up study in a goat model.
Technical Report, HEALICOIL Implant Volume Comparison. Internal Report. 15010823 Rev A. 63 Altschuler N, Zaslav KR, Di Matteo B, et al. Aragonite-Based Scaffold Versus Microfracture and Debridement for the Treatment of Knee Chondral and Osteochondral Lesions: Results of a Multicenter Randomized Controlled Trial. Am J Sports Med. 2023;51(4):957-967. 64 Kon E, Di Matteo B, Verdonk P, et al.
Comparison of nasal tampons for the treatment of epistaxis in the emergency department: a randomized controlled trial. Ann Emerg Med. 2005;45(2):134-9. 61 Van Kampen C, Arnoczky S, Parks P, et al. Tissue-engineered augmentation of a rotator cuff tendon using a reconstituted collagen scaffold: a histological evaluation in sheep. Muscles Ligaments Tendons J. 2013;3(3):229 235. 62 Smith+Nephew 2021.
OTO open. 2023;7(1):e22. 57 Smith+Nephew 2023.ARIS Targeted Hemostasis. Internal Memo. 10094398 Rev A. 58 Lustig LR, Ingram A, Vidrine M, et. al. In-Office Tympanostomy Tube Placement in Children Using Iontophoresis and Automated Tube Delivery. Laryngoscope. 2020;130:S1 S9, 2020. 59 IFU007011, available at www.tulatubes.com/IFU. 60 Singer AJ, Blanda M, Cronin K, et al.
Coblation tonsillectomy: A prospective, double-blind, randomised, clinical and histopathological comparison with dissection-ligation, monopolar electrocautery and laser tonsillectomies. J Laryngol Otol. 2008;122:282 290. 56 Sedgwick MJ, Saunders C, Bateman N. Intracapsular Tonsillectomy Using Plasma Ablation Versus Total Tonsillectomy: A Systematic Literature Review and Meta-Analysis.
Mechanical properties of all-suture anchors for rotator cuff repair. Bone Joint Res. 2017;6(2):82-89. 32 Ruder JA, Dickinson EY, Peindl RD, Habet NA, Trofa DP, Fleischli JE. Cyclic and Load-to-Failure Properties of All-Suture Anchors in Human Cadaveric Shoulder Glenoid Bone. Arthroscopy. 2019;35(7):1954-1959 e1954. References from business unit sections continued Other information continued 286 Smith+Nephew Annual Report 2024 55 Magdy EA, Elwany S, El-Daly AS, Abdel-Hadi M, Morshedy MA.
Rev A. 28 Smith + Nephew 2013.ULTRATAPE Pressure Film Testing. 15001847. Rev A. 29 ArthroCare 2019. Comparative Testing of Bone Anchor Devices, 1.8mm Q-FIX Mini Soft Suture Anchor P/N 49193-02 Rev.B. 30 Barber FA, Herbert MA. All-Suture Anchors: Biomechanical Analysis of Pullout Strength, Displacement, and Failure Mode. Arthroscopy. 2017;33(6):1113-1121. 31 Nagra NS, Zargar N, Smith RD, Carr AJ.
Orthop Traumatol Surg Res. 2019;14(1):12. 25 Smith+Nephew 2010. Micro-CT and histological evaluation of specimens from resorbable screw study (RS-II/OM1-08) 24-month post-implantation. Internal Report WRP-TE045-700-08. 26 Smith+Nephew 2016. Healicoil Regenesorb Suture Anchor a study to assess implant replacement by bone over a 2 year period. NCS248. 27 Smith + Nephew 2016.Feasability, MINITAPE Knot Stack Evaluation and Knot Security. 15005268.
Bony ingrowth of coil-type open-architecture anchors compared with screw-type PEEK anchors for the medial row in rotator cuff repair: a randomized controlled trial. Arthroscopy. 2019 Dec 3. 2020;36(4):952 961. 24 Vonhoegen J, John D, H germann C. Osteoconductive resorption characteristics of a novel biocomposite suture anchor material in rotator cuff repair.
J Orthop Res. 2021 Jul;39(7):1368-1382. 22 Espejo-Reina A, Sevillano-P rez E, Espejo-Reina M, Lombardo-Torre M, P rez-Blanca A, Espejo-Baena A. Arthroscopy, Sports Medicine and Rehabilitation. The Proportion of Meniscus Tears Considered Repairable, and Thus Repaired, Increased During a Single Surgeon's Practice of 20 Years. 2023; 5(5):100778. 23 Chahla J, Liu JN, Manderle B, et al.
Biomechanical Evaluation of Classic Solid and All-Soft Suture Anchors for Medial Patellofemoral Ligament Reconstruction. Am J Sports Med. 2017;45(7):1622-1626. 21 Bansal S, Floyd ER, A Kowalski M, Aikman E, Elrod P, Burkey K, Chahla J, LaPrade RF, Maher SA, Robinson JL, Patel JM. Meniscal repair: The current state and recent advances in augmentation.
The effect on healing rate of the addition of a bioinductive implant to a rotator cuff repair. The results of a randomized controlled trial in 124 subjects. ISAKOS 2023. 19 Bernardoni E, Frank RM, Veera SS, et al. Biomechanical Analysis of All-Suture Anchor Fixation for Rotator Cuff Repair. Orthop J Sports Med. 2018;6(7 suppl4). 20 Saper MG, Meijer K, Winnier S, Popovich J, Jr., Andrews JR, Roth C.
J Shoulder Elbow Surg. 2024;33(9):1894-1904. 17 Ruiz Ib n M , Garc a Navlet M, Moros Marco S, et al. Augmentation of a Transosseous-Equivalent Repair in Posterosuperior Nonacute Rotator Cuff Tears With a Bioinductive Collagen Implant Decreases the Retear Rate at 1 Year: A Randomized Controlled Trial. Arthroscopy. 2024;40(6):1760-1773. 18 Ruiz Iban MA et al.
Muscles, Ligaments Tendons J. 2019;9(3):338 347. 15 McElvany MD, McGoldrick E, Gee AO, Neradilek MB, Matsen FA, 3rd. Rotator cuff repair: published evidence on factors associated with repair integrity and clinical outcome. Am J Sports Med. 2015;43(2):491 500. 16 Camacho Chac n JA, Roda Rojo V, Martin Martinez A, et al. An isolated bioinductive repair vs sutured repair for full-thickness rotator cuff tears: 2-year results of a double blinded, randomized controlled trial.
Muscles, Ligaments Tendons J. 2015;5(3):144 150. 13 Schlegel TF, Abrams JS, Bushnell BD, Brock JL, Ho CP. Radiologic and clinical evaluation of a bioabsorbable collagen implant to treat partial-thickness tears: a prospective multicenter study. J Shoulder Elbow Surg. 2018 27(2):242 251. 14 Bokor DJ, Sonnabend DH, Deady L, et al. Healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a highly porous collagen implant: a 5-year clinical and MRI follow-up.
J Shoulder Elbow Surg. 2021 Aug;30(8):1938 1948. 11 Yeazell S, Lutz A, Bohon H, Shanley E, Thigpen CA, Kissenberth MJ, Pill SG. Increased stiffness and reoperation rate in partial rotator cuff repairs treated with a bovine patch: a propensity-matched trial. J Shoulder Elbow Surg. 2022 Jun;31(6S):S131 S135. 12 Bokor DJ, Sonnabend D, Deady L et al. Preliminary investigation of a biological augmentation of rotator cuff repairs using a collagen implant: a 2-year MRI follow-up.
Orthop J Sports Med. 2021 Aug 13;9(8). 9 Dai A, Campbell A, Bloom D, Baron S, Begly J, Meislin R. Collagen-Based Bioinductive Implant for Treatment of Partial Thickness Rotator Cuff Tears. Bull Hosp Jt Dis (2013). 2020 Sep;78(3):195 201. 10 Schlegel TF, Abrams JS, Angelo RL, Getelman MH, Ho CP, Bushnell BD. Isolated bioinductive repair of partial-thickness rotator cuff tears using a resorbable bovine collagen implant: two-year radiologic and clinical outcomes from a prospective multicenter study.
Bioinductive collagen implants facilitate tendon regeneration in rotator cuff tears. J Exp Orthop. 2022 Jun 8;9(1):53. 8 Bushnell BD, Bishai SK, Krupp RJ, McMillan S, Schofield BA, Trenhaile SW, McIntyre LF. Treatment of Partial-Thickness Rotator Cuff Tears With a Resorbable Bioinductive Bovine Collagen Implant: 1-Year Results From a Prospective Multicenter Registry.
Bio-inductive implant for rotator cuff repair: our experience and technical notes. Acta Biomed. 2020 Dec 30;91(14 S). 6 Thon SG, O'Malley L 2nd, O'Brien MJ, Savoie FH 3rd. Evaluation of Healing Rates and Safety With a Bioinductive Collagen Patch for Large and Massive Rotator Cuff Tears: 2-Year Safety and Clinical Outcomes. Am J Sports Med. 2019 Jul;47(8):1901 1908. 7 Camacho-Chacon JA, Cuenca-Espierrez J, Roda-Rojo V, Martin-Martinez A, Calderon-Meza JM, Alvarez-Alegret R, Martin-Hernandez C.
Arthrosc Sports Med Rehabil. 2021 Aug 20;3(5):e1473 e1479. 4 Bushnell BD, Connor P, Harris HW, Ho CP, Trenhaile SW, Abrams JS. Two-year outcomes with a bioinductive collagen implant used in augmentation of arthroscopic repair of full-thickness rotator cuff tears: Final results of a prospective multi-center study. J Shoulder Elbow Surg. 2022;31(12):2532-41. 5 Micheloni GM, Salmaso G, Zecchinato G, Giaretta S, Barison E, Momoli A.
Muscles, Ligaments Tendons J 2016;6(1):16 25. 2 Arnoczky SP, Bishai SK, Schofield B, et al. Histologic Evaluation of Biopsy Specimens Obtained After Rotator Cuff Repair Augmented With a Highly Porous Collagen Implant. Arthroscopy. 2017 Feb;33(2):278-283. 3 McIntyre LF, McMillan S, Trenhaile SW, Bishai SK, Bushnell BD. Full-Thickness Rotator Cuff Tears Can Be Safely Treated With Resorbable Bioinductive Bovine Collagen Implant: One-Year Results of a Prospective, Multicenter Registry.
PROCISE LW & MLW, Thermal Measurement and Comparison to CO2 and KTP Laser Systems. Internal Report. P/N 86257 Rev. A. 54 Smith+Nephew 2010. PROcise XP Comparative Thermal Measurement Bench-Top Study. Internal Report. P/N 60736 01 Rev. A. References from Sports Medicine & ENT (pages 43 46) 1 Bokor DJ, Sonnabend D, Deady L, et al. Evidence of healing of partial-thickness rotator cuff tears following arthroscopic augmentation with a collagen implant: a 2-year MRI follow-up.
Temperature Study PEAK PlasmaBlade TnA and Covidien EDGE . Internal Report. PN 86791 Rev. 1. 52 Roje Z, Racic G, Dogas Z, Pesuti Pisac V, Timms M. Postoperative morbidity and histopathologic characteristics of tonsillar tissue following coblation tonsillectomy in children: A prospective randomized single-blind study. Coll Antropol. 2009;33:293 298. 53 Smith+Nephew 2010.
Knee Surg Sports Traumatol Arthrosc. 2008;16(6):565 573. 48 Smith+Nephew 2021.Protocol, Claims, PLATINUM MDU- Torque. Internal Report. 15011440 Rev A. 49 Smith+Nephew 2017. Coblation Dissection Versus Monopolar Dissection A Systematic Review and Meta-analysis P/N 91999 Rev. A. 50 Temple RH, Timms MS. Paediatric coblation tonsillectomy. Int J Pediatr Otorhinolaryngol. 2001;61(3):195 198. 51 Smith+Nephew 2010.
ANAKIN Expected Life Summary Report. Internal Report. 15011066 Rev A. 45 TUV Rheinland 2022. SNE LENS 4K 60601-1 Report. Internal Report. 31892667.001. 46 ArthroCare 2014.Comparative Performance of the FLOW 50 Wand and the Predicate Wands in Tissue Models. P/N 52918-01. 47 Spahn G, Kahl E, Muckley T, Hofmann GO, Klinger HM. Arthroscopic knee chondroplasty using a bipolar radiofrequency-based device compared to mechanical shaver: results of a prospective, randomized, controlled study.
Internal Report. 15012288 Rev A. 41 Smith+Nephew 2023. Competitive Claims, Q-FIX with Needles, Fixation Report. Internal Report. 10093596 Rev A. 42 Smith+Nephew 2022. ANAKIN Shock and Vibration (Advantech Test Report). Internal Report. 15011068 Rev A. 43 Smith+Nephew 2022. INTELLIO 4K CCU Environmental Testing. Internal Report. 15010785 Rev A. 44 Smith+Nephew 2022.
Chondrocyte viability and metabolic activity after treatment of bovine articular cartilage with bipolar radiofrequency: an in vitro study. Arthroscopy. 2004;20(5):503-510. 39 Smith+Nephew 2023. Verif, Q-FIX with Needles Hard Bone Insertion, Fixation, and Cyclic. Internal Report. 15012313 Rev A. 40 Smith+Nephew 2023. Verif, Q-FIX with Needles Fixation (12pcf, 25/5pcf), Needle Attachment Strength, and Knot Tensile Strength Testing.
Internal Report. 10090792- Revision B. 37 Bergstein V., Ahiarakwe U, Haft M, Mikula J, Best M. Decreasing Incidence of Partial Meniscectomy and Increasing Incidence of Meniscus Preservation Surgery From 2010 to 2020 in the United States. Arthroscopy: The Journal of Arthroscopic & Related Surgery. 2024 Aug. 10:S0749-8063(24)00558-9. 38 Amiel D, Ball ST, Tasto JP.
Mechanical properties of all-suture anchors for rotator cuff repair. Bone Joint Res. 2017;6(2):82-89. 35 Ruder JA, Dickinson EY, Peindl RD, Habet NA, Trofa DP, Fleischli JE. Cyclic and Load-to-Failure Properties of All-Suture Anchors in Human Cadaveric Shoulder Glenoid Bone. Arthroscopy. 2019;35(7):1954-1959 e1954. 36 Smith and Nephew 2023. Q-FIX with MINITAPE Claims Report.
Compared to a competitive shoulder system. Smith+Nephew Annual Report 2024 285 STRATEGIC REPORT GOVERNANCE ACCOUNTS OTHER INFORMATION 33 Douglass NP, Behn AW, Safran MR. Cyclic and Load to Failure Properties of All-Suture Anchors in Synthetic Acetabular and Glenoid Cancellous Bone. Arthroscopy. 2017;33(5):977-985 e975. 34 Nagra NS, Zargar N, Smith RD, Carr AJ.
We are grateful to the Healthcare Quality Improvement Partnership (HQIP), the NJR Steering Committee and staff at the NJR Centre for facilitating this work. The views expressed represent those of the authors and do not necessarily reflect those of the National Joint Registry Steering Committee or the Health Quality Improvement Partnership (HQIP) who do not vouch for how the information is presented. *** Compared to NAVIO Handheld Robotics. **** Compared to Mako and ROSA. ***** With use of handpiece.
JArthroplasty. 2021;36:1445-1454. 50.Watson J, Jordan J. LEGION Primary Knee System for total knee arthroplasty: Design rationale and early results. Bone & Joint Science. 2015;5(1):1-8. 51.Naito Y, et al. BMC Muscoskeletal Disorders. 2021:1:1-8. * Based on BSC evidence. ** We thank the patients and staff of all the hospitals in England, Wales and Northern Ireland who have contributed data to the National Joint Registry.
Knee. 2009;16(5):332-336. 48.Grieco TF, Sharma A, Dessinger GM, Cates HE, Komistek RD. In Vivo Kinematic Comparison of a Bicruciate Stabilized Total Knee Arthroplasty and the Normal Knee Using Fluoroscopy. J Arthroplasty. 2018;33(2):565-571. 49.Smith LA, Nachtrab J, LaCour M, et al. In Vivo Knee Kinematics: How Important Are the Roles of Femoral Geometry and the Cruciate Ligaments?
Operating room and sterilization efficiencies for total, revision and unicompartmental knee arthroplasty using a handheld robotic-assisted surgical system. Poster presented at: ISPOR 2024; May 5-8, 2024; Atlanta, GA, USA. 47.Carpenter RD, Brilhault J, Majumdar S, Ries MD. Magnetic resonance imaging of in vivo patellofemoral kinematics after total knee arthroplasty.
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Impact of humeral and glenoid component variations on range of motion in reverse geometry total shoulder arthroplasty. A standardised computer model study. (8214). Swiss Medical Weekly. 2020;150(SUPPL 244):2S. 23.Kalouche I, Sevivas N, Wahegaonker A, Sauzieres P, Katz D, Valenti P. Reverse shoulder arthroplasty: Does reduced medialisation improve radiological and clinical results?
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Poster presented at: ISTA 2 5 October, 2019; Toronto, Canada. 18.Geller JA, Rossington A, Mitra R, Jaramaz B, Khare R, Netravali NA. Rate of learning curve and alignment accuracy of an image-free handheld robot for total Knee Arthroplasty. European Knee Society Arthroplasty Conference;2019; Valencia, Spain. 19.Ponzio DY, Lonner JH. Preoperative Mapping in Unicompartmental Knee Arthroplasty Using Computed Tomography Scans Is Associated with Radiation Exposure and Carries High Cost.
The Learning Curve and Alignment Assessment of an Image-Free Handheld Robot in TKA: The First Patient Series in Europe. Poster presented at: 19th Annual Meeting of the International Society for Computer Assisted Orthopaedic Surgery 2019; New York, USA. 17. Kopjar B, Schwarzkopf R, Chow J, et al. NAVIO Robotic Assisted Surgical System for Total Knee Arthroplasty Using JOURNEY II Guided-Motion Total Knee System.
March 2020. Internal Report ER0488 REVB. 14.Smith+Nephew 2020. Comparison of operating room footprint for robotic-assisted knee arthroplasty systems. Internal Report. EO.REC.PCS015.002.v1. 15.Gregori A, Picard F, Bellemans J, Smith JR, Simone A. Handheld Precision Sculpting Tool for Unicondylar Knee Arthroplasty. A Clinical Review. Poster presented at: 15th EFORT Congress; 4 6 June, 2014; London, UK. 16.Bollars P, Boeckxstaens A, Mievis J, Janssen D.
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Unless the context indicates otherwise, the following terms have the meanings shown below: Glossary Smith+Nephew Annual Report 2024 283 STRATEGIC REPORT GOVERNANCE ACCOUNTS OTHER INFORMATION Accounting policies 196 247 Accounts presentation 276 Acquisitions 19, 23, 26 27, 47, 68, 76, 91, 95 96, 110, 117, 131, 202 203, 245 246, Acquisition and disposal related items 18, 23, 25, 202 203, 268 269 American Depositary Shares 272 Articles of Association 174 177 Audit fees 134, 205 Board 104 107 Business overview 2 5, 256 Business segment information 39 50, 199 203 Cash and borrowings 221 223 Chair's statement 6 9 Chief Executive Officer's review 10 13 Company balance sheet 248 Company notes to the accounts 250 255 Contingencies 230 232, 252 Critical judgements and estimates 197 Cross-reference to Form 20-F 278 280 Currency fluctuations 264 Currency translation 198 Deferred taxation 208 209 Directors' Remuneration Report 136 177 Directors' responsibility statement 179 Dividends 7, 242 Earnings per share 24, 192, 209 Employee share plans 247 Executive team 108 109 Factors affecting results of operations 264 Financial instruments 224 230 Financial review 20 27 Free cash flow 269 Glossary of terms 283 Goodwill 212 214 Group balance sheet 193 Group cash flow statement 194 Group companies 252 255 Group history 276 Group income statement 192 Group notes to the accounts 196 247 Group overview 2 5, 256 Group statement of changes in equity 195 Group statement of comprehensive income 192 Independent auditor's report 180 191 Intangible assets 214 216 Intellectual property disputes 232 Interest and other finance costs 205 Inventories 218 Investments 216 Investment in associates 216 217 Key Performance Indicators 18 19 Legal and other 203, 268 269 Legal proceedings 232 Leverage ratio 270 Liquidity and capital resources 26, 223 Manufacturing and quality 34 35 Medical education 3, 6, 19, 32 33 Net debt 221 New accounting standards 196-197 Operating profit 203 204 Other finance costs 205 Our approach to stakeholders 116 118 Our global markets 40, 44, 48 Outlook and trend information 9, 27, 257 264 People/Employees 66 Post balance sheet events 247 Provisions 230 232 Property, plant and equipment 210 211 Regulation 15, 35, 69 70, 84 85 Related party transactions 247, 256 Research & development 29 31, 91, 203 204 Restructuring and rationalisation expenses 203, 268 269 Retirement benefit obligations 233 239 Return on invested capital (ROIC) 18, 21, 26 27, 271 Risk factors 257 264 Risk report 78 95 SASB reporting 281 282 Share-based payments 247 Share capital 240 242 Shareholder information 272 277 Staff costs and employee numbers 205 Stakeholder statement 116 117 Statement of compliance 103 Strategy for Growth 10 13 Sustainability 65 77 Taxation 206 209 Taxation information for shareholders 274 276 TCFD reporting 69 73 Total shareholder return 168 169 Trade and other payables 220 Trade and other receivables 219 220 Treasury shares 241 242 Index Other information continued 284 Smith+Nephew Annual Report 2024 References from business unit sections References from Elevating the Standard of Care (pages 28 35) 1.
UK United Kingdom of Great Britain and Northern Ireland. Underlying growth Growth after adjusting for the effects of currency translation and the inclusion of the comparative impact of acquisitions and exclusion of disposals. US United States of America. US Dollars, $, or cents or References to US currency. 1 cent is equivalent to one hundredth of US$1.
The adjustments made exclude the impact of specific transactions that management considers affect the Group's short-term profitability and cash flows, and comparability of results. Refer to page 265 for further information. Trauma & Extremities A product group which includes internal and external devices used in the stabilisation of severe fractures and deformity correction procedures.
SEC US Securities and Exchange Commission. Sports Medicine Joint Repair Sports Medicine Joint Repair includes instruments, technologies and implants necessary to perform minimally invasive surgery of joints. Trading results Trading profit, trading profit margin (trading profit expressed as a percentage of revenue), trading cash flow and trading profit to trading cash conversion ratio (trading cash flow expressed as a percentage of trading profit) are trend measures, which present the profitability of the Group.
Management believes that OXINIUM material used in the production of components of knee and hip implants exhibits unique performance characteristics due to its hardness, low-friction and resistance to roughening and abrasion. Parent Company Smith & Nephew plc. Pound Sterling, Sterling, , pence or p References to UK currency. 1p is equivalent to one hundredth of 1.
Other Reconstruction A product group which includes robotics-assisted surgery, bone cement and accessory products. OXINIUM OXINIUM material is an advanced load bearing technology. It is created through a proprietary manufacturing process that enables zirconium to absorb oxygen and transform to a ceramic on the surface, resulting in a material that incorporates the features of ceramic and metal.
NHS The UK National Health Service. NYSE New York Stock Exchange. Orthopaedic products Orthopaedic reconstruction products include joint replacement systems for knees, hips and shoulders and support products such as computer-assisted surgery and minimally invasive surgery techniques. Orthopaedic trauma devices are used in the treatment of bone fractures including rods, pins, screws, plates and external frames.
Knee implants A product group which includes an innovative range of products for specialised knee replacement procedures. LSE London Stock Exchange. MDR Medical Device Regulation. MHRA The Medicines and Healthcare products Regulatory Agency in the UK. Negative Pressure Wound Therapy (NPNT) A technology used to treat chronic wounds such as diabetic ulcers, pressure sores and post-operative wounds through the application of sub-atmospheric pressure to an open wound.
Health economics A branch of economics concerned with issues related to efficiency, effectiveness, value and behaviour in the production and consumption of health and healthcare. Hip Implants A product group which includes specialist products for reconstruction of the hip joint. IFC Inside Front Cover. IBC Inside Back Cover. Term Meaning IFRS International Financial Reporting Standards issued by the International Accounting Standards Board.
Euro or References to the common currency used in the majority of the countries of the European Union. FDA US Food and Drug Administration. Financial statements Refers to the consolidated Group Accounts of Smith & Nephew plc. FTSE 100 Index of the largest 100 listed companies on the London Stock Exchange by market capitalisation. Group or Smith+Nephew Used for convenience to refer to the Company and its consolidated subsidiaries, unless the context otherwise requires.
Emerging Markets Emerging Markets include Latin America, Asia (excluding Japan), Middle East, Africa and Russia. EPSA Adjusted earnings per ordinary share as defined on page 268. Endoscopy Through a small incision, surgeons are able to see inside the body using a monitor and identify and repair defects. ENT Ear, Nose and Throat. Established Markets Established Markets are United States of America, Europe, Australia, New Zealand, Canada and Japan.
ASC Ambulatory Surgery Center. Basis Point One hundredth of one percentage point. Chronic wounds Chronic wounds are those with long or unknown healing times including leg ulcers, pressure sores and diabetic foot ulcers. Company Smith & Nephew plc or, where appropriate, the Company's Board of Directors, unless the context otherwise requires. Companies Act Companies Act 2006, as amended, of England and Wales.
Advanced Wound Devices (AWD) A product group which includes traditional and single-use Negative Pressure Wound Therapy, a patient monitoring system for pressure injury prevention and patient mobility monitoring, and hydrosurgery systems. AGM Annual General Meeting of the Company. Arthroscopy Endoscopy of the joints is termed arthroscopy', with the principal applications including the knee and shoulder.