Soligenix, Inc.

Soligenix, Inc. Prices $8,000,000 Public

Offering At The Market

Princeton, NJ - June 28, 2018

- Soligenix, Inc. (Nasdaq: SNGX), a late-stage biopharmaceutical company focused on developing and commercializing products

to treat rare diseases where there is an unmet medical need, announced the pricing of an underwritten public offering of 7,766,990

shares of its common stock and warrants to purchase 3,106,796 shares of common stock at a combined public offering price of $1.03

per share and warrant. The warrants will have an initial per share exercise price of $2.25, subject to customary adjustment,

are exercisable immediately and will expire forty-two (42) months from the date of issuance. The gross proceeds to Soligenix, Inc.

from this offering are expected to be approximately $8,000,000, before deducting underwriting discounts and commissions and other

estimated offering expenses. Soligenix, Inc. has granted the underwriters a 45-day option to purchase up to an additional 1,165,048

shares of common stock and/or additional warrants to purchase up to 466,019 shares of common stock to cover over-allotments, if

any. The offering is expected to close on July 2, 2018, subject to customary closing conditions.

The closing price of the Company's

common stock on June 27, 2018, was $1.03 per share on the NASDAQ CM.

A.G.P./Alliance Global Partners acted

as the sole book-running manager for the offering.

A registration statement relating to these

securities has been filed with the Securities and Exchange Commission (the SEC) and became effective on June 27, 2018 and is available

on the SEC's website located at http://www.sec.gov.

The offering will be made only by means

of a prospectus. A copy of the prospectus relating to the offering may be obtained, when available, by contacting A.G.P./Alliance

Global Partners, 590 Madison Avenue, 36th Floor, New York, NY 10022 or via telephone at 212-624-2006 or email: prospectus@allianceg.com.

Investors may also obtain these documents at no cost by visiting the SEC's website at http://www.sec.gov. Before investing

in this offering, interested parties should read in their entirety the prospectus and the other documents that Soligenix, Inc.

has filed with the SEC that are incorporated by reference in such prospectus, which provide more information about Soligenix, Inc.

This press release shall not constitute

an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any state or jurisdiction

in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of

any such state or jurisdiction.

About Soligenix, Inc.

Soligenix is a late-stage biopharmaceutical

company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need. Our BioTherapeutics

business segment is developing SGX301 as a novel photodynamic therapy utilizing safe visible light for the treatment of cutaneous

T-cell lymphoma, our first-in-class innate defense regulator (IDR) technology, dusquetide (SGX942) for the treatment of oral mucositis

in head and neck cancer, and proprietary formulations of oral beclomethasone 17,21-dipropionate (BDP) for the prevention/treatment

of gastrointestinal (GI) disorders characterized by severe inflammation including pediatric Crohn's disease (SGX203) and

acute radiation enteritis (SGX201).

Our Vaccines/BioDefense

business segment includes active development programs for RiVax , our ricin toxin vaccine candidate, OrbeShield ,

our GI acute radiation syndrome therapeutic candidate and SGX943, our therapeutic candidate for antibiotic resistant and emerging

infectious disease. The development of our vaccine programs incorporates the use of our proprietary heat stabilization platform

technology, known as ThermoVax . To date, this business segment has been supported with government grant and contract

funding from the National Institute of Allergy and Infectious Diseases (NIAID) and the Biomedical Advanced Research and Development

For further information regarding Soligenix,

Inc., please visit the Company's website at www.soligenix.com.

This press release may contain forward-looking

statements that reflect Soligenix, Inc.'s current expectations about its future results, performance, prospects and opportunities,

including but not limited to, the proposed public offering, potential market sizes, patient populations and clinical trial enrollment.

Statements that are not historical facts, such as "anticipates," "estimates," "believes," "hopes,"

"intends," "plans," "expects," "goal," "may," "suggest," "will,"

"potential," or similar expressions, are forward-looking statements. These statements are subject to a number of

risks, uncertainties and other factors, many of which are difficult to predict, including market conditions and the satisfaction

of customary closing conditions related to the proposed offering, which could cause actual events or results in future periods

to differ materially from what is expressed in, or implied by, these statements. Soligenix cannot assure you that it will

be able to successfully develop, achieve regulatory approval for or commercialize products based on its technologies, particularly

in light of the significant uncertainty inherent in developing therapeutics and vaccines against bioterror threats, conducting

preclinical and clinical trials of therapeutics and vaccines, obtaining regulatory approvals and manufacturing therapeutics and

vaccines, that product development and commercialization efforts will not be reduced or discontinued due to difficulties or delays

in clinical trials or due to lack of progress or positive results from research and development efforts, that it will be able to

successfully obtain any further funding to support product development and commercialization efforts, including grants and awards,

maintain its existing grants which are subject to performance requirements, enter into any biodefense procurement contracts with

the US Government or other countries, that it will be able to compete with larger and better financed competitors in the biotechnology

industry, that changes in health care practice, third party reimbursement limitations and Federal and/or state health care reform

initiatives will not negatively affect its business, or that the US Congress may not pass any legislation that would provide additional

funding for the Project BioShield program. In addition, the offering is subject to market and other conditions, and there can be

no assurance as to the estimated proceeds from the offering and the anticipated use of proceeds from the offering. These and other

risk factors are described from time to time in filings with the Securities and Exchange Commission, including, but not limited

to, Soligenix's registration statement on Form S-1 for the proposed offering and reports on Forms 10-Q and 10-K. Unless required

by law, Soligenix assumes no obligation to update or revise any forward-looking statements as a result of new information or future

Chief Financial Officer

(609) 538-8200 | www.soligenix.com