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Soligenix Inc. (NASDAQ: SNGX) Proprietary Platform Aims to Meet Growing Need for Effective CTCL Therapy

Key Takeaway: Soligenix Inc. is advancing its HyBryte(TM) platform, a novel therapy for cutaneous T-cell lymphoma (CTCL), targeting an unmet need in the aging population. The company has established domestic manufacturing for the active ingredient and is moving towards potential commercialization following a successful Phase 3 study. This initiative aligns with broader efforts to improve access to treatments for rare diseases.
Price reaction · baseline $3.2 (2025-08-06 close) · hit pre-market · clean, no other SNGX news in the window
day 0 close · peak
+2.8%

Market Sentiment Analysis

POSITIVE FACTORS

  • Soligenix is advancing a new therapy for CTCL, addressing an unmet medical need.
  • The company has established U.S.-based manufacturing for its therapy, promoting domestic innovation.
  • HyBryte(TM) shows potential for commercialization after successful Phase 3 study.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Cash runway
~17 mo
Low dilution risk
Lead asset
Hypericin
Phase 2 · Cutaneous T Cell Lymphoma

Full Press Release Details

NEW YORK, Aug. 07, 2025 (GLOBE NEWSWIRE) -- viaInvestorWire— Soligenix Inc. (NASDAQ: SNGX) today announces its placement in an editorial published byNetworkNewsWire("NNW"), one of 70+ brands within theDynamic Brand Portfolio@IBN(InvestorBrandNetwork), a specialized communications platform with a focus on financial news and content distribution for private and public companies and the investment community.
To view the full publication, “Clinical Progress in Rare Disease Signals Long-Term Revenue Potential for Innovators,” please visit:https://nnw.fm/QCrhc.
As the American population gets older, chronic and rare diseases are becoming a significant healthcare issue, particularly for older adults. The aging population's increasing life expectancy also leads to more complex healthcare needs, especially for conditions that are both chronic and difficult to diagnose. Many of these rare conditions lack FDA-approved treatments, and their symptoms in seniors are frequently mistaken for normal signs of aging, causing diagnostic delays that can last for years. There are more than 30 million Americans who have a rare disease, so there is a growing need for accurate diagnoses and effective treatments.
The Trump administration's "Make America Healthy Again" initiatives have highlighted this problem and focused on improving access to treatments and speeding up medical innovation. Soligenix Inc. (NASDAQ: SNGX) is working to advance this mission with its HyBryte(TM) platform, a new therapy for cutaneous T-cell lymphoma (CTCL), a rare form of skin cancer that largely impacts older adults. The company has successfully established U.S.-based manufacturing for HyBryte's active ingredient, demonstrating the kind of domestic innovation that can significantly help this underserved patient group.
AboutSoligenix Inc.
Soligenix is a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need. Its Specialized BioTherapeutics business segment is developing and moving toward potential commercialization of HyBryte(TM) (“SGX301” or synthetic hypericin) as a novel photodynamic therapy utilizing safe visible light for the treatment of cutaneous T-cell lymphoma (“CTCL”). With successful completion of the second Phase 3 study, regulatory approvals will be sought to support potential commercialization worldwide. Development programs in this business segment also include expansion of synthetic hypericin (“SGX302”) into psoriasis, the company’s first-in-class innate defense regulator (“IDR”) technology, dusquetide (“SGX942”) for the treatment of inflammatory diseases, including oral mucositis in head and neck cancer, and (“SGX945”) in Behçet’s disease.
The company’s Public Health Solutions business segment includes development programs for RiVax(R), its ricin toxin vaccine candidate, as well as its vaccine programs targeting filoviruses (such as Marburg and Ebola) and CiVax(TM), the company’s vaccine candidate for the prevention of COVID-19 (caused by SARS-CoV-2). The development of Soligenix’s vaccine programs incorporates the use of its proprietary heat stabilization platform technology, known as ThermoVax(R). To date, this business segment has been supported with government grants and contract funding from the National Institute of Allergy and Infectious Diseases (“NIAID”), the Defense Threat Reduction Agency (“DTRA”) and the Biomedical Advanced Research and Development Authority (“BARDA”).
For further information, visit the company’s website atwww.Soligenix.com.
NOTE TO INVESTORS:The latest news and updates relating to SNGX are available in the company’s newsroom athttps://ibn.fm/SNGX

About NetworkNewsWire

NetworkNewsWire(“NNW”) is a specialized communications platform with a focus on financial news and content distribution for private and public companies and the investment community. It is one of 60+ brands within theDynamic Brand Portfolio@IBNthat delivers:(1) access to a vast network of wire solutions via InvestorWire to efficiently and effectively reach a myriad of target markets, demographics and diverse industries;(2) article andeditorial syndication to 5,000+ outlets;(3)press release enhancementto ensure maximum impact;(4)social media distributionvia IBN to millions of social media followers;and (5) a full array of tailoredcorporate communications solutions. With broad reach and a seasoned team of contributing journalists and writers, NNW is uniquely positioned to best serve private and public companies that want to reach a wide audience of investors, influencers, consumers, journalists and the general public. By cutting through the overload of information in today’s market, NNW brings its clients unparalleled recognition and brand awareness. NNW is where breaking news, insightful content and actionable information converge.
For more information, please visithttps://www.NetworkNewsWire.com
Please see full terms of use and disclaimers on the NetworkNewsWire website applicable to all content provided by NNW, wherever published or republished:https://www.NetworkNewsWire.com/Disclaimer
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Frequently Asked Questions

What is HyBryte(TM)?

HyBryte(TM) is a novel photodynamic therapy developed by Soligenix for treating cutaneous T-cell lymphoma.

What is the significance of the Phase 3 study?

The successful completion of the second Phase 3 study is crucial for Soligenix to seek regulatory approvals for HyBryte(TM).

How does HyBryte(TM) benefit older adults?

HyBryte(TM) addresses the specific healthcare needs of older adults suffering from CTCL, a rare skin cancer.

What other diseases is Soligenix targeting?

In addition to CTCL, Soligenix is developing treatments for psoriasis and inflammatory diseases.

Last updated: Aug 7, 2025