Semler Scientific Announces Updated BTC & ATM Activity; Purchased Additional 111 BTC; Now Holds 3,303 BTC; YTD BTC Yield of 23.5% S anta Clara, CA

Semler Scientific Announces

Updated BTC & ATM Activity;

Purchased Additional 111 BTC; Now Holds 3,303

BTC; YTD BTC Yield of 23.5%

Clara, CA - April 25, 2025 - Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in

developing and marketing technology products and services to assist its customers in evaluating and treating chronic diseases, today

announced updates regarding its bitcoin (BTC) activity, holdings and yield, as well as its at-the-market equity offering (ATM) programs.

Between February 14, 2025 and April 24, 2025, Semler Scientific acquired

111 bitcoins for $10.0 million with an average purchase price of $90,124 per bitcoin, inclusive of fees and expenses, using proceeds from

its ATM offering and cash on hand. As of April 24, 2025, Semler Scientific held 3,303 bitcoins, which were acquired for an aggregate $290.4

million at an average purchase price of $87,929 per bitcoin, inclusive of fees and expenses and had a market value of $309.1 million based

on the price of bitcoin as reported on the Coinbase exchange as of 4pm ET on such date.

ATM Offering Program

Semler Scientific entered into a Controlled Equity OfferingSM

Sales Agreement (the initial Sales Agreement) with Cantor Fitzgerald & Co., pursuant to which could issue and sell from time to time

up to $150.0 million of its common stock in an ATM offering. As of April 22, 2025, Semler Scientific had issued and sold an aggregate

of 2,438,274 shares of its common stock under the initial Sales Agreement for aggregate net proceeds (less sales commissions) of approximately

$126.0 million. As the registration statement and prospectus for the new ATM offering became effective on April 22, 2025, Semler Scientific

is no longer selling any shares under the initial Sales Agreement.

On April 15, 2025, Semler Scientific entered into a new Controlled

Equity OfferingSM Sales Agreement (the new Sales Agreement) with Barclays Capital Inc., Cantor Fitzgerald & Co., Canaccord

Genuity LLC, Needham & Company, LLC, Craig-Hallum Capital Group LLC and Lake Street Capital Markets, LLC pursuant to which it may

issue and sell from time to time up to $500.0 million of its common stock in an ATM offering. From the time of effectiveness to April

24, 2025, Semler Scientific has issued and sold 57,100 shares of its common stock for aggregate net proceeds (less sales commissions)

of approximately $2.0 million under the new Sales Agreement.

BTC Yield as a Key Performance Indicator (KPI)

Semler Scientific's BTC Yield was 23.5% YTD through April 24,

2025. Semler Scientific uses BTC Yield as a KPI to help assess the performance of its strategy of acquiring bitcoin in a manner Semler

Scientific believes is accretive to stockholders. Semler Scientific believes this KPI can be used to supplement an investor's understanding

of Semler Scientific's decision to fund the purchase of bitcoin by issuing additional shares of its common stock or instruments

convertible to common stock.

BTC Yield and Basic and Assumed Diluted Shares Outstanding

Important Information about BTC Yield KPI

BTC Yield is a KPI that represents the percentage change period-to-period

of the ratio between Semler Scientific's bitcoin holdings and its Assumed Diluted Shares Outstanding. Assumed Diluted Shares Outstanding

refers to the aggregate of Semler Scientific's actual shares of common stock outstanding as of the end of each period plus all additional

shares that would result from the assumed conversion of all outstanding convertible notes and exercise of all outstanding stock option

awards. Assumed Diluted Shares Outstanding is not calculated using the treasury method and does not take into account any vesting conditions

(in the case of equity awards), the exercise price of any stock option awards or any contractual conditions limiting convertibility of

outstanding convertible notes or settlement of capped calls.

Semler Scientific uses BTC Yield as a KPI to help assess the performance

of its strategy of acquiring bitcoin in a manner Semler Scientific believes is accretive to stockholders. Semler Scientific believes this

KPI can be used to supplement an investor's understanding of its decision to fund the purchase of bitcoin by issuing additional

shares of its common stock. When Semler Scientific uses this KPI, management also takes into account the various limitations of this metric,

including that it assumes the outstanding convertible notes will be converted into shares of common stock and the capped calls will be

settled in accordance with their respective terms.

Additionally, this KPI is not, and should not be understood as, an

operating performance measure or a financial or liquidity measure. In particular, BTC Yield is not equivalent to a "yield"

in the traditional financial context. It is not a measure of the return on investment Semler Scientific's stockholders may have

achieved historically or can achieve in the future by purchasing stock of Semler Scientific, or a measure of income generated by Semler

Scientific's operations or its bitcoin holdings, return on investment on its bitcoin holdings, or any other similar financial measure

of the performance of its business or assets.

The trading price of Semler Scientific's common stock is informed

by numerous factors in addition to the amount of bitcoins Semler Scientific holds and number of actual or potential shares of its stock

outstanding. As a result, the market value of Semler Scientific's shares may trade at a discount or a premium relative to the market

value of the bitcoin Semler Scientific holds. BTC Yield is not indicative nor predictive of the trading price of Semler Scientific's

shares of common stock. As noted above, this KPI is narrow in its purpose and is used by management to assist in assessing whether Semler

Scientific is using equity capital in a manner accretive to stockholders solely as it pertains to its bitcoin holdings.

In calculating this KPI, Semler Scientific does not take into account

the source of capital used for the acquisition of its bitcoin. Semler Scientific notes in particular, it has acquired bitcoin using cash

flow from operations, proceeds from the sale of shares in its ATM offering, as well as from the offering of convertible notes, which at

the time of issuance and including the capped calls had, and may from time-to-time thereafter have, conversion prices above the current

trading prices of Semler Scientific's common stock, or as to which the holders of such convertible notes may not then be entitled

to exercise the conversion rights of the notes. Conversely, if Semler Scientific's convertible notes mature or are redeemed without

being converted into common stock, Semler Scientific may be required to sell shares in quantities greater than the shares such convertible

notes and related capped calls are convertible into or generate cash proceeds from the sale of bitcoin, either of which would have the

effect of decreasing the BTC Yield due to changes in Semler Scientific's bitcoin holdings and shares in ways that were not contemplated

by the assumptions in calculating BTC Yield. Accordingly, this metric might overstate or understate the accretive nature of Semler Scientific's

use of capital to buy bitcoin because not all bitcoin may be acquired using proceeds of equity and convertible debt offerings and not

all issuances of equity may involve the acquisition of bitcoin.

Semler Scientific's ability to achieve positive BTC Yield may

depend on a variety of factors, including its ability to generate cash from operations in excess of its fixed charges and other expenses,

as well as factors outside of its control, such as the availability of debt and equity financing on favorable terms. Past performance

is not indicative of future results.

Semler Scientific has historically not paid dividends on its shares

of common stock, and by presenting this KPI, Semler Scientific makes no suggestion that it intends to do so in the future. Ownership of

common stock does not represent an ownership interest in the bitcoin Semler Scientific holds.

Investors should rely on the financial statements and other disclosures

contained in Semler Scientific's filings with the Securities and Exchange Commission (SEC). This KPI is merely a supplement, not

a substitute. It should be used only by sophisticated investors who understand its limited purpose and many limitations.

Forward-Looking Statements

This press release contains "forward-looking" statements.

Such statements can be identified by, among other things, the use of forward-looking language such as the words "believe," "goal,"

"may," "will," "intend," "expect," "anticipate," "estimate," "project,"

"would," "could" or words with similar meaning or the negatives of these terms or by the discussion of strategy or

intentions. The forward-looking statements in this release include statements regarding acquiring and holding bitcoin; its BTC yield;

and other express or implied statements regarding the ATM offering and its healthcare business. Such forward-looking statements are subject

to a number of risks and uncertainties that could cause Semler Scientific's actual results to differ materially from those discussed here,

such as risks inherent with settlement of government investigations and negotiating terms with multiple parties; risks related to borrowing

funds, including changing interest rates and credit markets and volatility in bitcoin; investing in bitcoin, including bitcoin's volatility;

risk of implementing a bitcoin treasury strategy; risks of indebtedness from the recent convertible notes offering; risks of settlement

with counterparties of the capped calls; along with those other risks related to its healthcare business and the risk factors detailed

in Semler Scientific's filings with the SEC. These forward-looking statements involve assumptions, estimates, and uncertainties that reflect

current internal projections, expectations or beliefs. There can be no assurance that such statements will prove to be accurate, and actual

results and future events could differ materially from those anticipated in such statements. All forward-looking statements contained

in this press release are qualified in their entirety by these cautionary statements and the risk factors described above. Furthermore,

all such statements are made as of the date of this press release and Semler Scientific assumes no obligation to update or revise these

statements unless otherwise required by law.

No Offer or Solicitation