Semler Scientific Announces Updated BTC Activity; Monetizes Minority Investment to Purchase BTC; Purchased Additional 871 BTC; Now Holds 3,192 BTC; YTD BTC Yield of 152.2% Since

Semler Scientific Announces

Updated BTC Activity; Monetizes Minority Investment to Purchase BTC;

Purchased Additional 871 BTC; Now Holds 3,192

BTC; YTD BTC Yield of 152.2% Since July 1, 2024

Santa Clara, CA - February 4, 2025 - Semler

Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products

and services to assist its customers in evaluating and treating chronic diseases, today announced updates regarding its bitcoin

(BTC) activity and holdings, and BTC Yield, a key performance indicator.

Between January 11, 2025 and February 3, 2025, Semler Scientific

acquired 871 bitcoins for $88.5 million with proceeds generated from its January 2025 senior convertible notes offering and monetization

of a portion of its minority investment in Monarch Medical Technologies, LLC. The average price of its bitcoin purchases was $101,616

per bitcoin, inclusive of fees and expenses. As of February 3, 2025, Semler Scientific held 3,192 bitcoins, which were acquired for

an aggregate $280.4 million at an average purchase price of $87,854 per bitcoin, inclusive of fees and expenses.

BTC Yield as a Key Performance Indicator (KPI)

From January 1, 2025 to February 3, 2025, Semler Scientific's

BTC Yield was 21.9%. From July 1, 2024 (the first full quarter after Semler Scientific adopted its bitcoin treasury strategy) to

February 3, 2025, Semler Scientific's BTC Yield was 152.2%.

Semler Scientific uses BTC Yield as a KPI to help assess the performance

of its strategy of acquiring bitcoin in a manner Semler Scientific believes is accretive to stockholders. Semler Scientific believes this

KPI can be used to supplement an investor's understanding of Semler Scientific's decision to fund the purchase of bitcoin

by issuing additional shares of its common stock or instruments convertible to common stock.

"We are thrilled with the progress we are making in growing our

bitcoin stockpile," said Eric Semler, chairman of Semler Scientific. "We were especially pleased with our successful

convertible notes offering, which was substantially oversubscribed with investor demand. Additionally, we were pleased to have monetized

a part of our investment in Monarch Medical in order to buy more bitcoin."

BTC Yield and Basic and Assumed Diluted Shares Outstanding

Important Information about BTC Yield KPI

BTC Yield is a KPI that represents the percentage change period-to-period

of the ratio between Semler Scientific's bitcoin holdings and its Assumed Diluted Shares Outstanding. Assumed Diluted Shares Outstanding

refers to the aggregate of Semler Scientific's actual shares of common stock outstanding as of the end of each period plus all additional

shares that would result from the assumed conversion of all outstanding convertible notes and exercise of all outstanding stock option

awards. Assumed Diluted Shares Outstanding is not calculated using the treasury method and does not take into account any vesting conditions

(in the case of equity awards), the exercise price of any stock option awards or any contractual conditions limiting convertibility of

outstanding convertible notes or settlement of capped calls.

Semler Scientific uses BTC Yield as a KPI to help assess the performance

of its strategy of acquiring bitcoin in a manner Semler Scientific believes is accretive to stockholders. Semler Scientific believes this

KPI can be used to supplement an investor's understanding of its decision to fund the purchase of bitcoin by issuing additional

shares of its common stock. When Semler Scientific uses this KPI, management also takes into account the various limitations of this metric,

including that it assumes the outstanding convertible notes will be converted into shares of common stock and the capped calls will be

settled in accordance with their respective terms.

Additionally, this KPI is not, and should not be understood as, an

operating performance measure or a financial or liquidity measure. In particular, BTC Yield is not equivalent to a "yield"

in the traditional financial context. It is not a measure of the return on investment Semler Scientific's stockholders may have

achieved historically or can achieve in the future by purchasing stock of Semler Scientific, or a measure of income generated by Semler

Scientific's operations or its bitcoin holdings, return on investment on its bitcoin holdings, or any other similar financial measure

of the performance of its business or assets.

The trading price of Semler Scientific's common stock is informed

by numerous factors in addition to the amount of bitcoins Semler Scientific holds and number of actual or potential shares of its stock

outstanding. As a result, the market value of Semler Scientific's shares may trade at a discount or a premium relative to the market

value of the bitcoin Semler Scientific holds. BTC Yield is not indicative nor predictive of the trading price of Semler Scientific's

shares of common stock. As noted above, this KPI is narrow in its purpose and is used by management to assist in assessing whether Semler

Scientific is using equity capital in a manner accretive to stockholders solely as it pertains to its bitcoin holdings.

In calculating this KPI, Semler Scientific does not take into account

the source of capital used for the acquisition of its bitcoin. Semler Scientific notes in particular, it has acquired bitcoin using cash

flow from operations, proceeds from the sale of shares in its at-the-market (ATM) offering, as well as from the offering of convertible

notes, which at the time of issuance and including the capped calls had, and may from time-to-time thereafter have, conversion prices

above the current trading prices of Semler Scientific's common stock, or as to which the holders of such convertible notes may not

then be entitled to exercise the conversion rights of the notes. Conversely, if Semler Scientific's convertible notes mature or

are redeemed without being converted into common stock, Semler Scientific may be required to sell shares in quantities greater than the

shares such convertible notes and related capped calls are convertible into or generate cash proceeds from the sale of bitcoin, either

of which would have the effect of decreasing the BTC Yield due to changes in Semler Scientific's bitcoin holdings and shares in

ways that were not contemplated by the assumptions in calculating BTC Yield. Accordingly, this metric might overstate or understate the

accretive nature of Semler Scientific's use of capital to buy bitcoin because not all bitcoin may be acquired using proceeds of

equity and convertible debt offerings and not all issuances of equity may involve the acquisition of bitcoin.

Semler Scientific's ability to achieve positive BTC Yield may

depend on a variety of factors, including its ability to generate cash from operations in excess of its fixed charges and other expenses,

as well as factors outside of its control, such as the availability of debt and equity financing on favorable terms. Past performance

is not indicative of future results.

Semler Scientific has historically not paid dividends on its shares

of common stock, and by presenting this KPI, Semler Scientific makes no suggestion that it intends to do so in the future. Ownership of

common stock does not represent an ownership interest in the bitcoin Semler Scientific holds.

Investors should rely on the financial statements and other disclosures

contained in Semler Scientific's filings with the Securities and Exchange Commission (SEC). This KPI is merely a supplement, not

a substitute. It should be used only by sophisticated investors who understand its limited purpose and many limitations.

Forward-Looking Statements

This press release contains "forward-looking" statements.

Such statements can be identified by, among other things, the use of forward-looking language such as the words "believe," "goal,"

"may," "will," "intend," "expect," "anticipate," "estimate," "project,"

"would," "could" or words with similar meaning or the negatives of these terms or by the discussion of strategy or

intentions. The forward-looking statements in this release include statements regarding acquiring and holding bitcoin; its BTC yield;

and other express or implied statements regarding the ATM offering, the recent convertible notes offering, capped call transactions and

its healthcare business. Such forward-looking statements are subject to a number of risks and uncertainties that could cause Semler Scientific's

actual results to differ materially from those discussed here, such as risks investing in bitcoin, including bitcoin's volatility; risk

of implementing a bitcoin treasury strategy; risks of indebtedness from the recent convertible notes offering; risks of settlement with

counterparties of the capped calls; along with those other risks related to its healthcare business and the risk factors detailed in Semler

Scientific's filings with the SEC. These forward-looking statements involve assumptions, estimates, and uncertainties that reflect current

internal projections, expectations or beliefs. There can be no assurance that such statements will prove to be accurate, and actual results

and future events could differ materially from those anticipated in such statements. All forward-looking statements contained in this

press release are qualified in their entirety by these cautionary statements and the risk factors described above. Furthermore, all such

statements are made as of the date of this press release and Semler Scientific assumes no obligation to update or revise these statements

unless otherwise required by law.

No Offer or Solicitation

This press release does not and shall not constitute an offer to sell

or a solicitation of an offer to buy any securities of Semler Scientific, nor shall there be any offer, solicitation or sale of such securities,

in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under

the securities laws of any such state or jurisdiction.

About Semler Scientific, Inc.:

Semler Scientific, Inc. is a

pioneer in developing and marketing technology products and services to assist its customers in evaluating and treating chronic diseases.