Semler Reports Third Quarter and Year-to-Date 2017 Financial Results Strong Revenue Growth Exceeded Increases in Expenses PORTLAND, Ore .

Semler Reports Third Quarter and Year-to-Date

2017 Financial Results

Strong Revenue Growth Exceeded Increases

PORTLAND, Ore. - October 31, 2017 - Semler

Scientific, Inc. (OTCQB: SMLR), an emerging growth company that provides technology solutions

to improve the clinical effectiveness and efficiency of healthcare providers, today reported financial results for the third

quarter and year-to-date ended September 30, 2017.

"Medical providers who want better clinical outcomes for

their patients and better economics for their businesses are ordering QuantaFlo systems," said Doug Murphy-Chutorian,

M.D., chief executive officer of Semler. "We are seeing revenue growth fueled by both new customers and our established base

of business," he added.

For the three months ended September 30, 2017, compared to the

corresponding period of 2016, Semler had:

For the nine months ended September 30, 2017, compared to the

corresponding period of 2016, Semler had:

For the three months ended September 30, 2017, compared

to three months ended June 30, 2017, Semler had:

THIRD QUARTER 2017 HIGHLIGHTS

The major accomplishments of the third quarter were to:

We expect revenue from QuantaFlo to continue to grow

due to an increasing number of installations resulting from new orders, higher average pricing as compared to its predecessor product

and the recurring revenue business models that we employ. A significant number of orders were installed near the end of the third

quarter of 2017 and will be billed beginning in October 2017, which we expect to result in continued quarterly revenue growth in

the fourth quarter of this year.

In the fourth quarter and over the next several months, we expect

expenses to continue to increase as the business expands. It is still our intent to grow revenue at a faster rate than expenses

and to achieve, and then sustain, profitability.

"Using our product, increasing numbers of medical providers

are testing patients in accordance with the American Heart Association and American College of Cardiology guidelines," said

Dr. Murphy-Chutorian. "The goal is to identify patients at risk for heart attacks and strokes, which in turn leads to the

initiation of better preventive medical care," he concluded.

Notice of Conference Call

Semler will host a conference call at 11 a.m. ET, October 31,

2017. The call will address third quarter and first nine months results and will provide a business update on Semler's market

outlook and strategies for the near-term future.

The conference call may be accessed by dialing 877-359-9508

for domestic callers and 224-357-2393 for international callers. Please specify to the operator that you would like to join the

"Semler Third Quarter 2017 Financial Results Call, conference ID#: 99812212." The conference call will be archived on

Semler's website at www.semlerscientific.com.

Semler Scientific, Inc.

Condensed Statements of Operations

(In thousands of U.S. Dollars, except for

share and per share data)

Semler Scientific, Inc.

Condensed Balance Sheets

(In thousands of U.S. Dollars)

About Semler Scientific, Inc.:

Semler Scientific, Inc. is an

emerging growth company that provides technology solutions to improve the clinical effectiveness and efficiency of healthcare

providers. Semler Scientific's mission is to develop, manufacture and market innovative proprietary products and services

that assist its customers in evaluating and treating chronic diseases. Semler Scientific's first patented and U.S.

Food and Drug Administration, or FDA, cleared product, introduced commercially in 2011, measured arterial blood flow in the extremities

to aid in the diagnosis of peripheral arterial disease. In March 2015, Semler Scientific received FDA 510(k) clearance for the

next generation version of this product named QuantaFlo , which was commercially launched in August 2015 to more comprehensively

evaluate our customers' patients for risk of heart attacks and strokes. Semler Scientific

believes it is positioned to provide valuable information to its insurance company and physician customers, which in turn permit

them to better guide patient care. Additional information about Semler can be found at semlerscientific.com.

Forward-Looking Statements

This press release contains "forward-looking" statements.

Such statements can be identified by, among other things, the use of forward-looking language such as the words "may,"

"will," "expect," "anticipate," "estimate," "project," "would,"

"could" or words with similar meaning or the negatives of these terms or by the discussion of strategy or intentions.

The forward-looking statements in this release include statements regarding the rate of customer orders, continued revenue growth

from QuantaFlo business, and growth in cost of revenue. Such forward-looking statements are subject to a number of risks

and uncertainties that could cause Semler Scientific's actual results to differ materially from those discussed here, such

as whether or not insurance plans and other customers will continue to lease its cardiovascular testing products, along with those

statements detailed in Semler Scientific's SEC filings, and involve assumptions, estimates, and uncertainties that reflect

current internal projections, expectations or beliefs. There can be no assurance that such statements will prove to be accurate,

and actual results and future events could differ materially from those anticipated in such statements. All forward looking statements

contained in this press release are qualified in their entirety by these cautionary statements and the risk factors described above.

Furthermore, all such statements are made as of the date of this release and Semler Scientific assumes no obligation to update

or revise these statements unless otherwise required by law.

S.A. Noonan Communications

SOURCE: Semler Scientific, Inc.