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Silence Therapeutics Announces Positive Topline Results from Phase 2 SANRECO Trial of Divesiran in Polycythemia Vera, Supporting its Potential Best-in-Class Profile

Key Takeaway: Silence Therapeutics has reported positive topline results from its Phase 2 SANRECO trial of divesiran, a novel siRNA therapy, in patients with polycythemia vera. The trial was randomized, double-blind, and placebo-controlled, involving 48 phlebotomy-dependent patients. These results support the potential of divesiran as a best-in-class treatment option.

Market Sentiment Analysis

POSITIVE FACTORS

  • Positive topline results from the Phase 2 SANRECO trial.
  • Divesiran shows potential as a first-in-class siRNA therapy.
  • The trial involved 48 patients, indicating robust clinical engagement.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Cash runway
~16 mo
Low dilution risk
Lead asset
Atu027 & gemcitabine in lead in safety period
Phase 1 · Carcinoma, Pancreatic Ductal

Full Press Release Details

LONDON--(BUSINESS WIRE)--$SLN#SenseofSilence--Silence Therapeutics plc, (Nasdaq: SLN), a global clinical-stage company developing novel siRNA (short interfering RNA) therapies, today announced a conference call and webcast to discuss topline results from the Phase 2 SANRECO trial of divesiran in polycythemia vera (PV) scheduled for tomorrow, Monday, August 10, 2026 at 8:00 a.m. EDT.

Investor Webcast & Conference Call Information

A replay of the webcast will be available on the Investors section of the Silence website atwww.silence-therapeutics.com/events.
About Silence TherapeuticsSilence Therapeutics is a global clinical-stage biotechnology company committed to transforming people’s lives by silencing diseases through precision engineered medicines created with proprietary siRNA (short interfering RNA) technology. Silence leverages its mRNAi GOLD™ platform to create innovative siRNA therapies designed to precisely target and silence genes that cause disease. The Company is advancing a growing pipeline of siRNA product candidates targeting areas of high unmet need across rare and common diseases where treatments are limited or inadequate. For more information, please visithttps://www.silence-therapeutics.com/.

Inquiries:

Silence Therapeutics plcGem Hopkins, VP, Head of IR and Corporate CommunicationsTel: +1 (646) 637-3208ir@silence-therapeutics.com

Frequently Asked Questions

What is the SANRECO trial?

The SANRECO trial is a Phase 2 study evaluating divesiran in patients with polycythemia vera.

What were the results of the SANRECO trial?

The trial reported positive topline results, supporting divesiran's potential as a treatment.

How many patients were involved in the trial?

The trial involved 48 phlebotomy-dependent patients.

What type of therapy is divesiran?

Divesiran is a first-in-class siRNA therapy developed by Silence Therapeutics.

Last updated: Aug 10, 2026