Full Press Release Details
Schr dinger Reports Second Quarter 2023 Financial Results
Announces IND Clearance for CDC7 Inhibitor SGR-2921, Continued Progress for MALT1 Inhibitor SGR-1505
Delivers Second Quarter Total Revenue of $35.2 Million
Raises 2023 Software Revenue Guidance and Reduces Drug Discovery Guidance
New York, August 2, 2023 - Schr dinger, Inc. (Nasdaq SDGR), whose physics-based computational platform is transforming the way therapeutics and materials are discovered, today announced financial results for the quarter ended on June 30, 2023.
"This year, we've witnessed unprecedented interest in computational drug discovery and, as leaders in this field, we are excited by the growing recognition that computational approaches can transform pharmaceutical innovation," said Ramy Farid, Ph.D., chief executive officer of Schr dinger. "During the second quarter, we made progress across all aspects of our business, building new capabilities in our platform, delivering revenue in line with our expectations and advancing our proprietary pipeline. We are very excited about our outlook for the balance of the year."
"We are pleased to report FDA clearance of our IND application for SGR-2921, our CDC7 inhibitor, and expect to initiate a Phase 1 clinical study in patients with acute myeloid leukemia or myelodysplastic syndrome this year," said Karen Akinsanya, Ph.D., president of R D therapeutics. "Our two SGR-1505 MALT1 inhibitor Phase 1 studies are progressing and we expect to share preliminary data from the healthy volunteer study later this year. In addition to these two clinical-stage programs, we continue to advance our discovery portfolio and look forward to providing updates on our pipeline later this year."
To support Schr dinger's continued pipeline progress, Margaret Dugan, M.D., joined the company as chief medical officer effective July 31, 2023. In this role, Dr. Dugan will be responsible for clinical development and regulatory strategy for Schr dinger's pipeline of wholly-owned programs. Dr. Dugan is a board certified medical oncologist and hematologist with more than 30 years of clinical, medical research, and drug development experience. Prior to joining Schr dinger, Dr. Dugan served as chief medical officer of Dracen Pharmaceuticals, an oncology company. During her career, she has held roles of increasing responsibility, including serving as a senior vice president at Novartis, where she led oncology-focused global strategic drug development, including several regulatory filings and approvals.
Today Schr dinger also announced that, for strategic reasons, Zai Lab has elected not to advance their discovery collaboration with Schr dinger to the next stage of development. In the two years of the collaboration, the joint team made substantial progress toward the technical goals for this complex target. The program is now wholly-owned by Schr dinger.
Second Quarter 2023 GAAP Financial Results
Total revenue for the second quarter was $35.2 million compared to $38.5 million in the second quarter of 2022.
Software revenue for the second quarter was $29.4 million compared to $30.0 million in the second quarter of 2022.
Drug discovery revenue was $5.8 million for the second quarter compared to $8.5 million in the second quarter of 2022.
Software gross margin was 77% for the second quarter compared to 76% in the second quarter of 2022.
Operating expenses were $74.9 million for the second quarter compared to $60.6 million for the second quarter of 2022.
Other income for the second quarter was $45.0 million compared to a loss of $4.2 million in the second quarter of 2022, driven by changes in the fair value of equity investments and interest income.
Net income for the second quarter was $4.3 million, compared to net loss of $47.7 million in the second quarter of 2022. During the second quarter, the company reported $20.4 million in tax benefit, reducing the company's tax liability recorded in the first quarter of 2023.
At June 30, 2023, Schr dinger had cash, cash equivalents, restricted cash and marketable securities of approximately $554 million, compared to approximately $456 million at December 31, 2022.
| Three Months Ended | |||||||||
| June 30, | |||||||||
| 2023 | 2022 | % Change | |||||||
| (in millions) | |||||||||
| Total revenue | $ | 35.2 | $ | 38.5 | -8.5% | ||||
| Software revenue | 29.4 | 30.0 | -2.2% | ||||||
| Drug discovery revenue | 5.8 | 8.5 | -31.0% | ||||||
| Software gross margin | 77 | % | 76 | % | |||||
| Operating expenses | $ | 74.9 | $ | 60.6 | 23.7% | ||||
| Other income (expense) | $ | 45.0 | $ | (4.2) | N M | ||||
| Net income (loss) | $ | 4.3 | $ | (47.7) | N M |
For the three and six months ended June 30, 2023, Schr dinger reported non-GAAP net losses of $56.8 million and $84.4 million, respectively, compared to non-GAAP net losses of $43.8 million and $72.1 million for the three and six months ended June 30, 2022, respectively. See "Non-GAAP Information" below and the table at the end of this press release for a reconciliation of non-GAAP net income (loss) to GAAP net income (loss).
2023 Financial Outlook
As of August 2, 2023, Schr dinger provided the following updated expectations for the fiscal year ending December 31, 2023
Software revenue growth is expected to be in the range of 15 percent to 18 percent.
Drug discovery revenue is now expected to range from $50 million to $70 million, compared to the prior expectation of $70 million to $90 million. This updated range reflects the company's new expectations for the timing of collaboration milestones and for the completion of new business development activity.
Software gross margin is expected to be similar to software gross margin for the full year 2022.
Operating expense growth in 2023 is expected to be significantly lower than operating expense growth in 2022.
Cash used for operating activities in 2023 is expected to be below cash used for operating activities in 2022.
For the third quarter of 2023, software revenue is expected to range from $27 million to $31 million.
Recent Company Highlights
Wholly-Owned Pipeline
Schr dinger continues to advance its MALT1 inhibitor, SGR-1505, in Phase 1 clinical development. Enrollment is ongoing in the dose-escalation study in patients with relapsed or refractory B-cell malignancies, and the company is expanding the patient study to Europe to support enrollment. Schr dinger is also conducting a Phase 1 dose-escalation study in healthy volunteers. Emerging data from the healthy volunteer study support further development, and the company expects to share preliminary data from this study later this year.
Today Schr dinger announced FDA clearance of its investigational new drug (IND) application for SGR-2921, the company's investigational CDC7 inhibitor. SGR-2921 has exhibited strong anti-tumor activity as a monotherapy and in combination with standard of care agents in multiple preclinical tumor models. The company expects to initiate a Phase 1 clinical trial this year. The study is designed to evaluate the safety, pharmacokinetics, pharmacodynamics, and determine the recommended dose of SGR-2921 in patients with acute myeloid leukemia or myelodysplastic syndrome.
Schr dinger continues to advance its Wee1 inhibitor, SGR-3515, through IND-enabling studies to support a potential IND submission in 2024.
The company continues to progress a pipeline of early-stage wholly-owned programs with potential across a broad range of therapeutic areas. Schr dinger is planning to share updates during its Pipeline Day. Given the timing of data availability, abstract submission and embargo periods associated with conferences, this event is now planned for December 2023 rather than the previously communicated September 28 date.
Schr dinger Collaborators
In July, Nimbus Therapeutics and Schr dinger published a paper highlighting the impact of computational physics-based predictions in the identification of TAK-279 (formerly NDI-034858), a TYK2 inhibitor currently in Phase 2 clinical trials for the treatment of psoriasis and psoriatic arthritis.
In June, Structure Therapeutics presented encouraging preclinical and Phase I single ascending dose data from GSBR-1290, an oral GLP-1R in development for Type 2 diabetes and obesity at the American Diabetes Association Scientific Sessions. Structure Therapeutics reported that GSBR-1290 has demonstrated encouraging safety and tolerability as well as a dose-dependent pharmacokinetic and pharmacodynamic profile.
In May, Morphic Therapeutic presented new biomarker data for MORF-057, an oral 4 7 inhibitor in development for ulcerative colitis and Crohn's disease at Digestive Disease Week 2023. Morphic Therapeutic reported that the preclinical data provide new support to mechanistic understanding of the activity of MORF-057 in ulcerative colitis.
Schr dinger scientists published research showing how, in the hit identification stage of drug discovery, the use of absolute protein-ligand binding free-energy perturbation (ABFEP) can substantially improve the hit rate compared to docking scores or other methods like metadynamics. The research confirms ABFEP as a useful tool for improving hit rates in virtual screening and thus facilitating hit discovery.
Schr dinger scientists published a paper describing a computational method to quantify protein reorganization free energy which is necessary to accurately predict binding free energies for ligands, a requirement to design ligands with stronger binding potency and selectivity. The use of two retrospective design case studies reinforces the method's utility and potential for computer-aided drug design to better support complex protein targets.
Webcast and Conference Call Information
Schr dinger will host a conference call to discuss its second quarter 2023 financial results on Wednesday, August 2, 2023, at 4 30 p.m. ET. The live webcast can be accessed under "News Events" in the investors section of Schr dinger's website, https ir.schrodinger.com news-and-events event-calendar. To access the call by phone, please dial 1-888-440-5983 (Toll-Free) or 1-646-960-0202 (Toll) and refer to conference ID 2440689. The archived webcast will be available on Schr dinger's website for approximately 90 days following the event.
Non-GAAP Information
Included in this press release is certain financial information that has not been prepared in accordance with generally accepted accounting principles in the United States (GAAP). The company presents non-GAAP net income (loss) and non-GAAP net income (loss) per share, which exclude gains and losses on equity investments, changes in fair value, and income tax benefits and expenses. Adjusting net income to exclude the impact of these items results in a financial presentation for the company without the impact of our equity investments and tax benefits and expenses. Management believes non-GAAP net income (loss) and non-GAAP net income (loss) per share are useful measures for investors, taken in conjunction with the company's GAAP financial statements because they provide greater period-over-period comparability with respect to the company's operating performance, by excluding non-cash mark-to-market and other valuation adjustments for the company's equity investments, non-recurring cash distributions from the company's equity investments and the tax impact of these distributions that are not reflective of the ongoing operating performance of the business. However, the non-GAAP measures should be considered only in addition to, not as a substitute for or as superior to, net income (loss) and net income (loss) per share or other financial measures prepared in accordance with GAAP.
Other companies in Schr dinger's industry may calculate non-GAAP net income (loss) and non-GAAP net income (loss) per share, differently than we do, limiting their usefulness as comparative measures. For a reconciliation of non-GAAP net income (loss) and non-GAAP net income (loss) per share to GAAP net income
(loss) and GAAP net income (loss) per share, respectively, please refer to the tables at the end of this press release.
Schr dinger is transforming the way therapeutics and materials are discovered. Schr dinger has pioneered a physics-based computational platform that enables discovery of high-quality, novel molecules for drug development and materials applications more rapidly and at lower cost compared to traditional methods. The software platform is licensed by biopharmaceutical and industrial companies, academic institutions, and government laboratories around the world. Schr dinger's multidisciplinary drug discovery team also leverages the software platform to advance a portfolio of collaborative and proprietary programs to address unmet medical needs.
Cautionary Note Regarding Forward-Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995 including, but not limited to those statements regarding Schr dinger's expectations about the speed and capacity of its computational platform, its financial outlook for the fiscal year ending December 31, 2023 and third quarter ending September 30, 2023, its plans to continue to invest in research and its strategic plans to accelerate the growth of its software licensing business and advance its collaborative and proprietary drug discovery programs, the long-term potential of its business, its ability to improve and advance the science underlying its platform, the initiation, timing, progress, and results of its proprietary drug discovery programs and product candidates and the drug discovery programs and product candidates of its collaborators, the clinical potential and favorable properties of its CDC7, MALT1, and Wee1 inhibitors, including SGR-1505, SGR-2921, and SGR-3515, the clinical potential and favorable properties of its collaborators' product candidates, as well as expectations related to the use of its cash, cash equivalents and marketable securities. Statements including words such as "aim," "anticipate," "believe," "contemplate," "continue," "could," "estimate," "expect," "goal," "intend," "may," "might," "plan," "potential," "predict," "project," "should," "target," "will," "would" and statements in the future tense are forward-looking statements. These forward-looking statements reflect Schr dinger's current views about its plans, intentions, expectations, strategies and prospects, which are based on the information currently available to the company and on assumptions the company has made. Actual results may differ materially from those described in these forward-looking statements and are subject to a variety of assumptions, uncertainties, risks and important factors that are beyond Schr dinger's control, including the demand for its software platform, its ability to further develop its computational platform, its reliance upon third-party providers of cloud-based infrastructure to host its software solutions, factors adversely affecting the life sciences industry, fluctuations in the value of the U.S. dollar and foreign currencies, its reliance upon its third-party drug discovery collaborators, the uncertainties inherent in drug development and commercialization, such as the conduct of research activities and the timing of and its ability to initiate and complete preclinical studies and clinical trials, whether results from preclinical studies will be predictive of the results of later preclinical studies and clinical trials, uncertainties associated with the regulatory review of IND submissions, clinical trials and applications for marketing approvals, and the ability to retain and hire key personnel on its business and other risks detailed under the caption "Risk Factors" and elsewhere in the company's Securities and Exchange Commission filings and reports, including its Quarterly Report on Form 10-Q for the fiscal quarter ended June 30, 2023, filed with the Securities and Exchange Commission on August 2, 2023, as well as future filings and reports by the company. Any forward-looking statements contained in this press release speak only as of the date hereof. Except as required by law, Schr dinger undertakes no duty or obligation to update any forward-looking statements contained in this press release as a result of new information, future events, changes in expectations or otherwise.
Matthew Luchini (Investors)
matthew.luchini schrodinger.com
Allie Nicodemo (Media)
allie.nicodemo schrodinger.com
Condensed Consolidated Statements of Operations (Unaudited)
(in thousands, except for share and per share amounts)
| Three months ended June 30, | Six months ended June 30, | ||||||||||||||
| 2023 | 2022 | 2023 | 2022 | ||||||||||||
| Revenues | |||||||||||||||
| Software products and services | $ | 29,352 | $ | 30,011 | $ | 61,565 | $ | 63,092 | |||||||
| Drug discovery | 5,837 | 8,458 | 38,406 | 24,040 | |||||||||||
| Total revenues | 35,189 | 38,469 | 99,971 | 87,132 | |||||||||||
| Cost of revenues | |||||||||||||||
| Software products and services | 6,695 | 7,101 | 13,810 | 14,612 | |||||||||||
| Drug discovery | 14,684 | 14,234 | 26,658 | 27,403 | |||||||||||
| Total cost of revenues | 21,379 | 21,335 | 40,468 | 42,015 | |||||||||||
| Gross profit | 13,810 | 17,134 | 59,503 | 45,117 | |||||||||||
| Operating expenses | |||||||||||||||
| Research and development | 42,705 | 31,123 | 83,446 | 58,945 | |||||||||||
| Sales and marketing | 9,022 | 7,428 | 18,167 | 14,099 | |||||||||||
| General and administrative | 23,216 | 22,056 | 49,524 | 44,189 | |||||||||||
| Total operating expenses | 74,943 | 60,607 | 151,137 | 117,233 | |||||||||||
| Loss from operations | (61,133) | (43,473) | (91,634) | (72,116) | |||||||||||
| Other income (expense) | |||||||||||||||
| Gain on equity investments | - | 11,828 | 147,322 | 11,828 | |||||||||||
| Change in fair value | 40,654 | (15,700) | 76,391 | (21,864) | |||||||||||
| Other income (expense) | 4,326 | (308) | 7,263 | 31 | |||||||||||
| Total other income (expense) | 44,980 | (4,180) | 230,976 | (10,005) | |||||||||||
| (Loss) income before income taxes | (16,153) | (47,653) | 139,342 | (82,121) | |||||||||||
| Income tax (benefit) expense | (20,431) | 33 | 5,928 | 5 | |||||||||||
| Net income (loss) | $ | 4,278 | $ | (47,686) | $ | 133,414 | $ | (82,126) | |||||||
| Net income (loss) per share of common and limited common stockholders, basic | $ | 0.06 | $ | (0.67) | $ | 1.86 | $ | (1.15) | |||||||
| Weighted average shares used to compute net income (loss) per share of common and limited common stockholders, basic | 71,642,722 | 71,161,892 | 71,555,395 | 71,106,470 | |||||||||||
| Net income (loss) per share of common and limited common stockholders, diluted | $ | 0.06 | $ | (0.67) | $ | 1.79 | $ | (1.15) | |||||||
| Weighted average shares used to compute net income (loss) per share of common and limited common stockholders, diluted | 75,064,323 | 71,161,892 | 74,499,672 | 71,106,470 |
Condensed Consolidated Balance Sheets (Unaudited)
(in thousands, except for share and per share amounts)
| Assets | June 30, 2023 | December 31, 2022 | |||||
| Current assets | |||||||
| Cash and cash equivalents | $ | 285,963 | $ | 90,474 | |||
| Restricted cash | 5,053 | 5,243 | |||||
| Marketable securities | 262,710 | 360,613 | |||||
| Accounts receivable, net of allowance for doubtful accounts of $250 and $125 | 9,652 | 55,953 | |||||
| Unbilled and other receivables, net for allowance for unbilled receivables of $100 and $100 | 14,585 | 13,137 | |||||
| Prepaid expenses | 13,999 | 8,569 | |||||
| Total current assets | 591,962 | 533,989 | |||||
| Property and equipment, net | 20,353 | 14,244 | |||||
| Equity investments | 106,404 | 25,683 | |||||
| Goodwill | 4,791 | 4,791 | |||||
| Intangible assets, net | - | 587 | |||||
| Right of use assets | 112,984 | 105,982 | |||||
| Other assets | 5,072 | 3,311 | |||||
| Total assets | $ | 841,566 | $ | 688,587 | |||
| Liabilities and Stockholders' Equity | |||||||
| Current liabilities | |||||||
| Accounts payable | $ | 12,428 | $ | 9,470 | |||
| Income taxes payable | 5,134 | 355 | |||||
| Accrued payroll, taxes, and benefits | 21,328 | 24,882 | |||||
| Deferred revenue | 46,674 | 57,931 | |||||
| Lease liabilities | 13,921 | 11,006 | |||||
| Other accrued liabilities | 7,317 | 5,166 | |||||
| Total current liabilities | 106,802 | 108,810 | |||||
| Deferred revenue, long-term | 15,620 | 25,598 | |||||
| Lease liabilities, long-term | 107,319 | 105,485 | |||||
| Other liabilities, long-term | 600 | 800 | |||||
| Total liabilities | 230,341 | 240,693 | |||||
| Stockholders' equity | |||||||
| Preferred stock, $0.01 par value. Authorized 10,000,000 shares zero shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively | - | - | |||||
| Common stock, $0.01 par value. Authorized 500,000,000 shares 62,702,244 and 62,163,739 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively | 627 | 622 | |||||
| Limited common stock, $0.01 par value. Authorized 100,000,000 shares 9,164,193 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively | 92 | 92 | |||||
| Additional paid-in capital | 856,913 | 828,700 | |||||
| Accumulated deficit | (245,724) | (379,138) | |||||
| Accumulated other comprehensive loss | (683) | (2,382) | |||||
| Total stockholders' equity | 611,225 | 447,894 | |||||
| Total liabilities and stockholders' equity | $ | 841,566 | $ | 688,587 |
Condensed Consolidated Statements of Cash Flows (Unaudited)
| Six Months Ended June 30, | |||||||||
| 2023 | 2022 | ||||||||
| Cash flows from operating activities | |||||||||
| Net income (loss) | $ | 133,414 | $ | (82,126) | |||||
| Adjustments to reconcile net income (loss) to net cash used in operating activities | |||||||||
| Gain on equity investments | (147,322) | (11,828) | |||||||
| Fair value adjustments | (76,391) | 21,864 | |||||||
| Depreciation and amortization | 2,925 | 2,095 | |||||||
| Stock-based compensation | 22,653 | 19,561 | |||||||
| Noncash (accretion) investment amortization | (2,858) | 1,719 | |||||||
| Loss (gain) on disposal of property and equipment | 63 | (4) | |||||||
| Gain on lease termination | - | - | |||||||
| Decrease (increase) in assets, net of acquisition | |||||||||
| Accounts receivable, net | 46,301 | 13,489 | |||||||
| Unbilled and other receivables | (1,448) | (4,095) | |||||||
| Reduction in the carrying amount of right of use assets | 3,720 | 3,140 | |||||||
| Prepaid expenses and other assets | (11,408) | (8,721) | |||||||
| Increase (decrease) in liabilities, net of acquisition | |||||||||
| Accounts payable | 192 | (2,979) | |||||||
| Income taxes payable | 4,779 | 41 | |||||||
| Accrued payroll, taxes, and benefits | (3,554) | (1,872) | |||||||
| Deferred revenue | (21,235) | (17,887) | |||||||
| Lease liabilities | (1,584) | 364 | |||||||
| Other accrued liabilities | 2,216 | 2,861 | |||||||
| Net cash used in operating activities | (49,537) | (64,378) | |||||||
| Cash flows from investing activities | |||||||||
| Purchases of property and equipment | (6,007) | (3,670) | |||||||
| Purchases of equity investments | (4,125) | (600) | |||||||
| Distribution from equity investment | 147,117 | 11,828 | |||||||
| Acquisition, net of acquired cash | - | (6,427) | |||||||
| Purchases of marketable securities | (125,714) | (111,215) | |||||||
| Proceeds from maturity of marketable securities | 228,174 | 180,710 | |||||||
| Net cash provided by investing activities | 239,445 | 70,626 | |||||||
| Cash flows from financing activities | |||||||||
| Issuances of common stock upon stock option exercises | 5,565 | 1,304 | |||||||
| Payment of offering costs | (174) | - | |||||||
| Net cash provided by financing activities | 5,391 | 1,304 | |||||||
| Net increase in cash and cash equivalents and restricted cash | 195,299 | 7,552 | |||||||
| Cash and cash equivalents and restricted cash, beginning of period | 95,717 | 123,267 | |||||||
| Cash and cash equivalents and restricted cash, end of period | $ | 291,016 | $ | 130,819 | |||||
| Supplemental disclosure of cash flow and noncash information | |||||||||
| Cash paid for income taxes | $ | 918 | $ | 171 | |||||
| Supplemental disclosure of non-cash investing and financing activities | |||||||||
| Accrued offering costs | 199 | - | |||||||
| Purchases of property and equipment in accounts payable | 2,935 | 80 | |||||||
| Purchases of property and equipment in accrued liabilities | 30 | - | |||||||
| Acquisition of right to use assets, contingency resolution | 514 | 1,513 | |||||||
| Acquisition of right of use assets in exchange for lease liabilities | 6,333 | 14,767 |
Reconciliation of GAAP to Non-GAAP Financial Measures (Unaudited)
| Three Months Ended | Six Months Ended | ||||||||||||||
| June 30, | June 30, | ||||||||||||||
| 2023 | 2022 | 2023 | 2022 | ||||||||||||
| (in thousands, except per share data) | |||||||||||||||
| Net income (loss) (GAAP) | $ | 4,278 | $ | (47,686) | $ | 133,414 | $ | (82,126) | |||||||
| Income tax expense (benefit) | (20,431) | 33 | 5,928 | 5 | |||||||||||
| Gain on equity investments | - | (11,828) | (147,322) | (11,828) | |||||||||||
| Change in fair value | (40,654) | 15,700 | (76,391) | 21,864 | |||||||||||
| Non-GAAP net loss | $ | (56,807) | $ | (43,781) | $ | (84,371) | $ | (72,085) | |||||||
| Non-GAAP net loss per share of common and limited common stockholders, basic and diluted | $ | (0.79) | $ | (0.62) | $ | (1.18) | $ | (1.01) |