Full Press Release Details
Repare Therapeutics Unveils Two Programs Expected to Enter Clinical Trials in 2024: RP-1664, an Oral PLK4 Inhibitor, and RP-3467, an Oral Pol Inhibitor
RP-1664 demonstrated potent and selective inhibition of PLK4 and synthetic lethality in TRIM37-high
tumor cells in preclinical studies
RP-3467 demonstrated complete, sustained regressions
preclinically in combination with PARPi, and compelling anti-tumor activity in combination with radioligand therapy (RLT) and chemotherapy
Company expects to initiate clinical trials of RP-1664 in 1H 2024 and
Repare to host conference call and webcast today at 8:00 a.m. ET
CAMBRIDGE, Mass. & MONTREAL (BUSINESS WIRE) November 15, 2023 Repare Therapeutics Inc. ( Repare or the
Company ) (Nasdaq: RPTX), a leading clinical-stage precision oncology company, today disclosed polo-like kinase 4 (PLK4) as the target of its RP-1664 development program and reported comprehensive
preclinical data for both RP-1664 and the Company s Pol inhibitor, RP-3467.
RP-1664 is a potential first-in-class,
selective, oral PLK4 inhibitor that is synthetic lethal with TRIM37 amplification or overexpression in solid tumors. Tumors rely on PLK4 for survival in the presence of high levels of TRIM37. Preclinical studies demonstrate RP-1664 drives potent synthetic lethality in TRIM37-high tumor models, both in vitro and in vivo. Elevated TRIM37 is a feature found across a range of solid tumors and in nearly all high-grade
RP-3467 is a potential
best-in-class inhibitor of DNA polymerase theta, or Pol . Pol is a synthetic
lethal target associated with homologous recombination deficiency (HRD) tumors, including those with BRCA1/2 mutations or other genomic alterations. Data suggest that RP-3467 works synergistically with
therapies that result in double stranded DNA breaks, such as PARP inhibition, radioligand therapy and multiple chemotherapies and antibody-drug conjugates (ADCs). Additionally, initial data suggest that
Pol inhibition may interfere with mechanisms central to the development of PARPi resistance.
excited to announce the initial clinical approach for RP-1664 based on highly compelling preclinical data supporting its potential for treating TRIM37-high tumors, said Lloyd M. Segal, President and CEO
of Repare. We are also pleased to share preclinical data from our RP-3467 program supporting its significant potential across multiple high-value therapeutic opportunities. These programs represent our
third and fourth internally developed clinical candidates and provide further confirmation of Repare s powerful discovery platform. We look forward to advancing both RP-1664 and RP-3467 into Phase 1 clinical trials in 2024.
RP-3467 Data Highlights
Preclinical data for
RP-1664 demonstrate early and promising activity in TRIM37-high tumors, including breast cancer, NSCLC and neuroblastoma, said Michael Zinda, Ph.D., EVP, Chief Scientific Officer of Repare. The
durable, complete regressions observed in the preclinical RP-3467 and PARPi combination studies are also extremely exciting and demonstrate the broad combination potential of our potent and selective Pol helicase inhibitor. Repare plans to investigate RP-3467 with a focus on its potential as a combination partner across agents that induce double stranded DNA breaks,
including RLT, ADCs, and a range of chemotherapies.
Conference Call and Webcast
Repare will host a conference call and webcast today, November 15, 2023, at 8:00 a.m. ET. To access the call, please dial (877) 870-4263 (U.S. and Canada) or (412) 317-0790 (international) at least 10 minutes prior to the start time and ask to be joined to the Repare Therapeutics call. A live webcast
will be available in the Investor section of the Company s website at https://ir.reparerx.com/events-and-presentations/events. A webcast replay will also be
archived for at least 30 days.
About Repare Therapeutics SNIPRx Platform
Repare s SNIPRx platform is a genome-wide CRISPR-based screening approach that utilizes
proprietary isogenic cell lines to identify novel and known synthetic lethal gene pairs and the corresponding patients who are most likely to benefit from the Company s therapies based on the genetic profile of their tumors. Repare s
platform enables the development of precision therapeutics in patients whose tumors contain one or more genomic alterations identified by SNIPRx screening, in order to selectively target
those tumors in patients most likely to achieve clinical benefit from resulting product candidates.
About Repare Therapeutics Inc.
Repare Therapeutics is a leading clinical-stage precision oncology company enabled by its proprietary synthetic lethality approach to the discovery and
development of novel therapeutics. The Company utilizes its genome-wide, CRISPR-enabled SNIPRx platform to systematically discover and develop highly targeted cancer therapies focused on
genomic instability, including DNA damage repair. The Company s pipeline includes lunresertib (also known as RP-6306), a PKMYT1 inhibitor currently in Phase 1 clinical development; camonsertib (also known
as RP-3500 or RG6526), a potential leading ATR inhibitor currently in Phase 1/2 clinical development and partnered with Roche; RP-3467, a preclinical Pol inhibitor program; RP-1664, a preclinical PLK4 inhibitor; as well as several additional, undisclosed preclinical programs. For more information, please visit
www.reparerx.com and follow @Reparerx on X (formerly Twitter) and LinkedIn.
SNIPRx is a registered trademark of Repare
Forward-Looking Statements
press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and securities laws in Canada. All statements in this press release other than statements of historical facts
are forward-looking statements. These statements may be identified by words such as aims, anticipates, believes, could, estimates, expects, forecasts,
goal, intends, may, plans, possible, potential, seeks, will and variations of these words or similar expressions that are intended to identify
forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements regarding: the design, objectives, initiation, timing, progress
and results of the Company s current and future preclinical studies and clinical trials, including specifically the clinical development of RP-1664 and RP-3467
programs; the tolerability, efficacy and clinical progress of RP-1664 and RP-3467; the potential of RP-1664 as a first-in-class oral PLK4 inhibitor and RP-3467 as a
best-in-class Pol inhibitor; and the benefits and ability to discover further targets and clinical candidates from the
Company s discovery platform. These forward-looking statements are based on the Company s expectations and assumptions as of the date of this press release. Each of these forward-looking statements involves risks and uncertainties that
could cause the Company s clinical development programs, future results or performance to differ materially from those expressed or implied by the forward-looking statements. Many factors may cause differences between current expectations and
actual results, including: success in preclinical testing and earlier clinical trials does not ensure that later clinical trials will generate the same results or otherwise provide adequate data to demonstrate the efficacy and safety of a product
candidate; the impacts of macroeconomic conditions, including the COVID-19 pandemic, the conflict in Ukraine and the conflict between Israel and Hamas, rising inflation, and uncertain credit and financial
markets on the Company s business, clinical trials and financial position; unexpected safety or efficacy data observed during preclinical studies or clinical trials; clinical trial site activation or enrollment rates that are lower than
expected; changes in expected or existing competition; changes in the regulatory environment; the uncertainties and timing of the regulatory approval process; and unexpected litigation or other disputes. Other factors that may cause the
Company s actual results to differ from those expressed or implied in the forward-looking statements in this press release are identified in the section titled Risk Factors in the Company s Annual Report on Form 10-K for the year ended December 31, 2022 filed with the Securities and Exchange Commission ( SEC ) and the Qu bec Autorit des March s Financiers ( AMF ) on
February 28, 2023, and its other documents subsequently filed with or furnished to the SEC and AMF including the Company s Quarterly Report on Form 10-Q for the quarter ended September 30, 2023
filed with the SEC on November 9, 2023. The Company expressly disclaims any obligation to update any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise,
except as otherwise required by law. For more information, please visit reparerx.com and follow Repare on Twitter at @RepareRx and on LinkedIn at https://www.linkedin.com/company/repare-therapeutics/.
Executive Vice-President and Chief Financial Officer
Repare Therapeutics Inc.