Forward-Looking Statements We caution the reader that this presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements other than statements of historical fact contai

June 9, 2025 NASDAQ: RNA |

aviditybio.com Investor & Analyst Event Series Delivering for People Living with Facioscapulohumeral Muscular Dystrophy (FSHD) Exhibit 99.1

Forward-Looking Statements We caution

the reader that this presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements other than statements of historical fact contained in this presentation are forward-looking statements.

Forward-looking statements include, but are not limited to, statements regarding: our business strategies and plans; research and development plans; the anticipated timing, costs, design, enrollment status, goals, dosage levels and

frequencies, and conduct of our ongoing and planned clinical trials for delpacibart braxlosiran (del-brax); the timing of release of data from our ongoing clinical programs; the characterization of data and results from the Phase

1/2 FORTITUDE trial, and conclusions drawn therefrom; our plans to file a BLA for accelerated approval of del-brax and the timing thereof; the potential for del-brax to achieve accelerated or full approval from regulators; the status of

feedback from the FDA regarding a regulatory path (including potential accelerated approval) for del-brax; the use of KHDC1L as a surrogate endpoint; topline data from the biomarker cohort of the FORTITUDE trial and the timing thereof; the

significance of the ReSolve natural history study as compared to topline data from the FORTITUDE trial; the ability of del-brax to improve the lives of people with FSHD; safety and tolerability, and functional benefit, of our product candidates; the

potential of the AOC platform; the ability of our product candidates to treat rare diseases; timing and likelihood of success; product approvals; plans and objectives of management for future operations; and future results of anticipated product

development efforts. In some cases, the reader can identify forward-looking statements by terms such as "may," "will," "should," "expect," "plan," "anticipate,"

"could," "intend," "target," "project," "contemplates," "believes," "estimates," "predicts," "potential" or "continue" or the

negative of these terms or other similar expressions. The inclusion of forward-looking statements should not be regarded as a representation by Avidity that any of our plans will be achieved. Actual results may differ from those set forth in this

presentation due to the risks and uncertainties inherent in our business and beyond our control, including, without limitation: additional requests for data by regulators may result in significant additional expense and timing delays; data delivered

to the FDA may not support accelerated approval pathways or BLA submissions and may not be satisfactory to the FDA, including as a result of our inability to establish that a novel biomarker may serve as a surrogate endpoint reasonably likely to

predict a clinical benefit; preliminary results of a clinical trial are not necessarily indicative of final results; additional participant data related to del-brax that continues to become available may be inconsistent with the data

produced as of the most recent date cutoff, and further analysis of existing data and analysis of new data may lead to conclusions different from those established as of such date cutoff; unexpected adverse side effects or inadequate efficacy of

del-brax may delay or limit its development, regulatory approval and/or commercialization, or may result in clinical holds which may not be timely lifted, recalls or product liability claims; we may not successfully achieve accelerated or full

approval for del-brax; we are early in our development efforts; our approach to the discovery and development of product candidates based on our AOC platform is unproven, and we do not know whether we will be able to develop any products of

commercial value; the results of early clinical trials are not necessarily predictive of future results; potential delays in the commencement, enrollment, data readouts and completion of clinical trials; our dependence on third parties in

connection with preclinical and clinical testing and product manufacturing; we may not realize the expected benefits of our collaborations with third parties, our existing collaborations may terminate earlier than expected or we may not be able to

form new collaborations; regulatory developments in the United States and foreign countries, including acceptance of INDs and similar foreign regulatory submissions and our proposed design of future clinical trials; Fast Track and Breakthrough

Therapy designations by the FDA may not lead to a faster development or regulatory review or approval process; our ability to obtain and maintain intellectual property protection for our product candidates and proprietary technologies; we may

exhaust our capital resources sooner than we expect and fail to raise additional needed funds; and other risks described in our filings with the SEC, including under the heading "Risk Factors" in our Form 10-K for the year ended December

31, 2024, filed with the SEC on February 27, 2025, and in subsequent filings with the SEC. The reader is cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Except as required by

applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise. All forward-looking statements are qualified

in their entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. This presentation also contains estimates and other statistical data made by independent parties

and by us relating to market size and growth and other data about our industry. This data involves a number of assumptions and limitations, and the reader is cautioned not to give undue weight to such estimates. In addition, projections,

assumptions, and estimates of our future performance and the future performance of the markets in which we operate are necessarily subject to a high degree of uncertainty and risk. These and other factors could cause results to differ materially

from those expressed in the estimates made by the independent parties and by us. This presentation shall not constitute an offer to sell or the solicitation of an offer to buy securities, nor shall there be any sale of securities in any state or

jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

OUR VISION To profoundly improve

people's lives by revolutionizing the delivery of RNA therapeutics Amy Living with FSHD Josh Living with FSHD

mAb OLIGO delpacibart braxlosiran

abbreviation: del-brax Poised for three successive BLA submissions in 12 months starting year-end 2025 Share FDA confirmation of accelerated approval pathway in US 1 Present FORTITUDE 12 Month Topline Data 2 Announce initiation of global

confirmatory Phase 3 study 3 Today's Update

Accelerating del-brax Toward Approval

Accelerated Approval Pathway is Open Consistent and Reproducible Topline Data Global Confirmatory Phase 3 Study Initiated Written confirmation from FDA that accelerated approval pathway is open Primary endpoint is reduction in circulating biomarker,

cDUX Anticipate biomarker cohort topline data in Q2 2026 and BLA submission in H2 2026 Unprecedented and consistent reduction in DUX4-regulated biomarkers Improved functional mobility and muscle strength Favorable safety and tolerability

Aligned with FDA on confirmatory Phase 3 FORWARD trial design 200 participants, 18-month trial initiated 1:1 randomized, double blind, placebo-controlled trial

Jeffrey M. Statland, M.D. Professor of

Neurology, University of Kansas Medical Center Steve Hughes, M.D. Chief Medical Officer Sarah Boyce President & CEO Michael Flanagan, Ph.D. Chief Scientific Officer Kat Lange Chief Business Officer Delivering for People Living with FSHD AVIDITY

MANAGEMENT TEAM GUEST SPEAKER

Agenda Delivering for People Living

with FSHD Sarah Boyce, President & CEO Advancing the First Potential FSHD Treatment Toward Regulatory Approvals Steve Hughes, M.D., CMO FORTITUDE Topline Data Jeffrey M. Statland, M.D., Professor of Neurology, University of Kansas Medical

Center A Game-Changing Circulating Biomarker for FSHD Michael Flanagan, Ph.D., CSO Registrational Studies Steve Hughes, M.D., CMO Closing Remarks Sarah Boyce, President & CEO Q&A Session Avidity Management & Dr. Statland Moderator: Kat

FORTITUDE 12 Month Topline

Readout Randomized, double-blind, placebo-controlled study FSHD participants ages 18-65 Primary and Secondary Objectives 2:1 Randomization Del-brax: Placebo (N = 12) (N = 27) Dose Booster Muscle biopsies to be performed at Baseline and 4 months

Multidose quarterly with 1 booster after first 6 weeks; Dose listed is siRNA Safety and tolerability of ascending doses of del-brax in participants with FSHD Pharmacokinetics 4 mg/kg cohort completed - Q13W dosing 2 mg/kg* cohort completed

- Q13W dosing * 2mg/kg cohort: first dose at 1 mg/kg; all subsequent doses at 2 mg/kg Study Design Key Exploratory Objectives Pharmacodynamics Biomarkers Patient and Clinician reported outcomes Clinical measures 10MWRT TUG QMT RWS 12-month

study duration QMT = quantitative muscle testing; 10MWRT = 10-meter walk-run test; TUG = timed up-and-go; RWS = Reachable Workspace; OLE = Open Label Extension OLE 2 mg/kg Q6W

Baseline Demographics and

Characteristics Placebo N=13 % or mean (SD) Del-brax 2 mg/kg* N=8 % or mean (SD) Del-brax 4 mg/kg N=18 % or mean (SD) Sex, % Male 92.3 62.5 50.0 Age, years 52.1 (9.92) 51.6 (11.62) 45.2 (11.49) Genetic Diagnosis, % FSHD 1 100 100 100 FSHD Clinical

Score 9.2 (2.28) 9.3 (2.31) 8.5 (1.92) D4Z4 Repeat Number 5.5 (2.03) 5.8 (2.60) 4.7 (1.53) Age at First Symptom Onset (y) 22.2 (15.54) 28.6 (17.75) 20.7 (13.82) *Participants receive a first dose of 1mg/kg and then receive the 2mg/kg dose for the

remainder of the study

Del-brax: Favorable Long-Term

Safety and Tolerability Including OLE Subjects with 1 AE n (%) Placebo N=13 2 mg/kg* N=8 4 mg/kg N=18 OLE** N=38 Any AE 12 (92.3%) 8 (100%) 18 (100%) 21 (55.3) Related to study drug 3 (23.1%) 6 (75%) 11 (61.1%) 9 (23.7%) Severe AE 0 0 0 2

(5.3%) Serious AE (SAE) 0 0 0 1 (2.6%) Severe or SAEs related to study drug 0 0 0 0 AE leading to study discontinuation 0 0 0 0 AE leading to death 0 0 0 0 All participants enrolled remain in study No discontinuations Most AEs mild or moderate No

related severe or serious AEs Most common related AEs occurring in greater than 3 participants: Fatigue Hemoglobin decreased 1 unrelated severe, non-serious AE of herpes zoster occurred in one participant 3 unrelated severe, serious AEs of radius

fracture, pelvic fracture, and fractured sacrum occurred in one participant *Participants receive a first dose of 1mg/kg and then receive the 2mg/kg dose for the remainder of the study **38 out of 39 participants had begun treatment in OLE; data as

of May 7th, 2025; Final participants began treatment in FORTITUDE-OLE after the data cut

Agenda Delivering for People Living

with FSHD Sarah Boyce, President & CEO Advancing the First Potential FSHD Treatment Toward Regulatory Approvals Steve Hughes, M.D., CMO FORTITUDE Topline Data Jeffrey M. Statland, M.D., Professor of Neurology, University of Kansas Medical

Center A Game-Changing Circulating Biomarker for FSHD Michael Flanagan, Ph.D., CSO Registrational Studies Steve Hughes, M.D., CMO Closing Remarks Sarah Boyce, President & CEO Q&A Session Avidity Management & Dr. Statland Moderator: Kat

Jeffrey M. Statland, M.D. is a

Professor of Neurology at the University of Kansas Medical Center in Kansas City, Kansas. His research background has centered primarily on describing the natural history of and response to therapy for neuromuscular diseases. He completed a

neuromuscular fellowship in Experimental Therapeutics of Neurological Diseases at the University of Rochester Medical Center and currently serves as principal investigator or co-investigator for research studies in Facioscapulohumeral Muscular

Dystrophy (FSHD), Duchenne Muscular Dystrophy, Spinal Muscular Atrophy, and Myotonic Dystrophy. His specific research interest over the last 10 years has been preparing for clinical trials in FSHD. He has systematically analyzed the performance of

strength and functional outcomes in prior FSHD clinical trials and compared to performance in natural history studies. He has worked with collaborators to develop new disease-relevant outcome measures to assess patient-reported disease burden,

functional impairment, and physiological changes in muscle. He along with his collaborators formed an FSHD Clinical Trial Research Network in 2016 which currently has 30 international centers participating in studies to increase our understanding of

FSHD and prepare for clinical trials. Jeffrey M. Statland, M.D. Professor of Neurology, University of Kansas Medical Center

Facioscapulohumeral Muscular

Dystrophy (FSHD) Rare, hereditary disorder causing relentless loss of muscle function and progressive disability One of the most common forms of muscular dystrophy, FSHD causes progressive muscle weakness, pain, fatigue and disability Onset

typically occurs in teenage or early adult years Steady loss of independence and ability to care for oneself 20% of participants become wheelchair dependent Autosomal dominant - multiple generations can be affected 20-30% arise from spontaneous

mutations Aberrant DUX4 expression is the underlying cause of disease 0 ~45,000 - 87,000 PEOPLE WITH FSHD IN THE US & EUROPE APPROVED THERAPIES Russell Living with FSHD

What Matters to Patients is to Have

Their Disease Under Control Over 60% of patients express that slowing or stopping the loss of muscle function would be the most meaningful outcome FSHD Voice of the Patient (June 2020) highlighted that the most meaningful outcome for patients is to

slow or stop the loss of muscle function. People living with FSHD are most worried about: the unknown of how the disease will progress losing independence losing mobility/ability to walk becoming a burden to their family Short of a cure, what

outcome is the most meaningful to you in a future treatment? Select your top choice. FSHD Society. Voice of the Patient Report: Externally Led Patient-Focused Drug Development Meeting. Published November 2020. Accessed June 2025.

Improved Functional Mobility in

del-brax Treated Participants Compared to Placebo Data at 12 months with Q13W dosing 10MWRT Change in seconds All del-brax data shown in this presentation is as of the May 2025 data cutoff date. All data shown are mean change ( SEM) from

Baseline to Month 12. 2mg/kg and 4mg/kg treatment arms pooled. 10MWRT = 10-meter walk-run test. One placebo participant had an unreliable baseline measurement and was removed from all analyses. One placebo and two del-brax participants did not

complete the assessment. Improving 10m

Improved Functional Mobility in

del-brax Treated Participants Compared to Placebo Data at 12 months with Q13W dosing TUG Change in seconds All data shown are mean change ( SEM) from Baseline to Month 12. 2mg/kg and 4mg/kg treatment arms pooled. TUG = timed up-and-go; maximal

effort. One placebo participant had an unreliable baseline measurement and was removed from all analyses. Two placebo and two del-brax participants did not complete the assessment. Improving 3m

Improved Strength in del-brax

Treated Participants Compared to Placebo All data shown are mean change ( SEM) from Baseline to Month 12. QMT = quantitative muscle testing, PPN = percent predicted normal. One placebo participant had an unreliable baseline measurement and was

removed from all analyses. 2mg/kg and 4mg/kg treatment arms pooled Data at 12 months with Q13W dosing QMT Elbow flexor/ extensor Shoulder abductors/ rotators Knee flexors/ extensors Ankle dorsiflexors Change in QMT PPN Improving

Improved Upper Limb Function in

del-brax Treated Participants Compared to Placebo Data at 12 months with Q13W dosing RWS Change in RSA All data shown are mean change ( SEM) from Baseline to Month 12. RWS = Reachable Workspace; RSA = Relative Surface Area. One placebo

participant had an unreliable baseline measurement and was removed from all analyses. 2mg/kg and 4mg/kg treatment arms pooled Q1 Q3 Q2 Q4 Average of 2 arms for Q1 and Q3 with weight Improving

Improved Functional Mobility in

del-brax Treated Participants Relative to Placebo Exceeding MCID at Both Doses All data shown are mean difference ( SEM) between del-brax and placebo for change from baseline at Month 12. TUG, maximal effort One placebo participant had an

unreliable baseline measurement and was removed from all analyses. One del-brax participant was removed from the 10MWRT results as they transitioned to using a walker due to a hamstring injury during the study. MCID = Minimal Clinically Important

Difference from ReSolve Study anchored to Current Abilities Scale. *Participants received a first dose of 1mg/kg and then received the 2mg/kg dose for the remainder of the study Favors del-brax Favors del-brax Change in 10MWRT (sec) relative to

placebo Change in TUG (sec) relative to placebo Del-brax 2mg/kg* (N = 7) Del-brax 4mg/kg (N = 17) MCID = 0.92 sec MCID = 1 sec Data at 12 months with Q13W dosing Dose regimen selected for registrational studies is 2mg/kg Q6W

Improved Strength and Upper Limb

Mobility in del-brax Treated Participants Relative to Placebo All data shown are mean difference ( SEM) between del-brax and placebo for change from baseline at Month 12. One placebo participant had an unreliable baseline measurement and was

removed from all analyses. *Participants received a first dose of 1mg/kg and then received the 2mg/kg dose for the remainder of the study. Dose regimen selected for registrational studies is 2mg/kg Q6W Favors del-brax Favors del-brax Change in QMT