Repligen Corporation 41 Seyon Street Building #1, Suite 100 Waltham, Massachusetts 02453 Repligen Reports Fourth Quarter and Full Year 2023 Financial Results Reports fourth quarter revenue of $156 million and full year r

Repligen Reports Fourth Quarter and Full Year 2023 Financial Results

WALTHAM, Mass., February 21, 2024

Repligen Corporation (NASDAQ:RGEN), a life sciences company focused on bioprocessing technology leadership, today reported financial results for its fourth quarter of 2023, covering the three- and twelve-month periods ended December 31,

2023. The company is also providing financial guidance for the full year 2024.

Tony J. Hunt, Chief Executive Officer of Repligen said, During the

fourth quarter, we again saw order strength, driven by our Filtration and Analytics franchises and continued momentum from new modality accounts, which reflects the differentiated nature of our products in this market. We are pleased to report

that for the second quarter in a row, our book-to-bill ratio was above 1.0, at 1.03 for the fourth quarter. Revenue for the quarter came in as expected with a nice

contribution from Metenova of $5 million, very much in-line with our expectations. While there are still pockets of headwinds and challenging macro factors in China, we remain optimistic that our

markets will improve as we advance through 2024, with growth accelerating in the second half of the year.

FOURTH QUARTER BUSINESS HIGHLIGHTS

FINANCIAL PERFORMANCE

For the full year 2023, total revenue was $638.8 million, compared to $801.5 million for 2022. Base revenue (non-GAAP) for 2023 was $599.1 million, compared to $660.5 million for 2022.

For the full year 2023, gross profit (GAAP) was $284.8 million, compared to $455.7 million for the full year 2022. Adjusted gross

profit (non-GAAP) for the full year 2023 was $316.5 million, compared to $456.9 million for 2022.

For the full year 2023, income from operations (GAAP) was $54.6 million, compared to $224.7 million for the full year 2022. Adjusted

income from operations (non-GAAP) for the full year 2023 was $94.3 million, compared to $232.2 million for 2022.

For the full year 2023, net income (GAAP) was $41.6 million, compared to $186.0 million for full year 2022. Adjusted net income (non-GAAP) for 2023 was $98.4 million compared to $188.6 million for 2022.

For the full year 2023, earnings per share (GAAP) was $0.74 on a fully diluted basis,

compared to $3.24 for 2022. Adjusted earnings per share (non-GAAP) for 2023 was $1.75 on a fully diluted basis, compared to $3.28 for 2022.

FINANCIAL GUIDANCE FOR FISCAL YEAR 2024

Our financial guidance for the fiscal year 2024 is based on expectations for our existing business. Our GAAP and Adjusted

(non-GAAP) guidance includes the expected impact of businesses acquired in 2023 (FlexBiosys and Metenova) and excludes the impact of any potential business acquisitions in 2024, and future fluctuations in

foreign currency exchange rates.

Our non-GAAP net income guidance for the fiscal year 2024 reflects

$54.2 million in adjustments, as referred to in the non-GAAP reconciliation table included later in this press release.

Conference Call and Webcast Access

Repligen will host a

conference call and webcast today, February 21, 2024, at 8:30 a.m. ET, to discuss fourth quarter 2023 financial results, corporate developments and financial guidance for the year 2024. The conference call will be accessible by dialing

toll-free (844) 274-3999 for domestic callers or (412) 317-5607 for international callers. No passcode is required for the live call. In addition, a webcast will be

accessible via the Investor Relations section of the Company s website. Both the conference call and webcast will be archived for a period of time following the live event. The replay dial-in numbers are

(877) 344-7529 from the U.S., (855) 669-9658 from Canada and (412) 317-0088 for international callers. Replay listeners must

provide the passcode 4526890.

About Repligen Corporation

Repligen Corporation is a global life sciences company that develops and commercializes highly innovative bioprocessing technologies and systems that enable

efficiencies in the process of manufacturing biological drugs. We are inspiring advances in bioprocessing for the customers we serve; primarily biopharmaceutical drug developers and contract development and manufacturing

organizations (CDMOs) worldwide. Our focus areas are Filtration and Fluid Management, Chromatography, Process Analytics and Proteins. Our corporate headquarters are located in Waltham, Massachusetts, and the majority of our manufacturing sites are

Non-GAAP Measures of Financial Performance

To supplement our financial statements, which are presented on the basis of U.S. generally accepted accounting principles (GAAP), the following non-GAAP measures of financial performance are included in this release: book-to-bill ratios, base business revenue growth, adjusted

gross profit, adjusted gross margin and adjusted operating margin; adjusted cost of sales; adjusted R&D expense; adjusted SG&A expense; adjusted pre-tax income; adjusted income from operations;

adjusted net income; adjusted earnings per share-diluted; adjusted earnings before interest, taxes, depreciation and amortization (EBITDA), and adjusted EBITDA margin. The Company provides base revenue and base revenue growth rates, which exclude

COVID-related revenue, and the impact of acquisition revenue for current year periods that have no prior year comparables, to facilitate a comparison of its current revenue performance. The Company provides the impact of foreign currency

translation, to enable determination of revenue growth rates at constant currency, which exclude the impact of foreign currency translation, in order to facilitate a comparison of its current revenue performance to its past revenue performance. To

calculate the impact of foreign currency translation, the Company converts actual net sales from local currency to U.S. dollars using constant foreign currency exchange rates in the current and prior period.

The Company s non-GAAP financial results and/or non-GAAP guidance exclude the impact of: inventory step-up charges; acquisition and integration costs; restructuring charges including the costs of severance; inventory

adjustments and accelerated depreciation among other charges; contingent consideration related to the Company s acquisitions; intangible amortization costs; loss on extinguishment of debt; non-cash

interest expense related to the accretion of the debt discount; amortization of debt issuance costs related to Company s convertible debt; foreign currency impact of certain intercompany loans; and, the related impact on tax of non-GAAP charges. These costs are excluded because management believes that such expenses do not have a direct correlation to future business operations, nor do the resulting charges recorded accurately reflect the

performance of our ongoing operations for the period in which such charges are recorded.

All reconciliations of above GAAP figures (reported or guidance) to adjusted (non-GAAP) figures are detailed in the

tables included later in this press release. When analyzing the Company s operating performance and guidance investors should not consider non-GAAP measures as a substitute for the comparable financial

measures prepared in accordance with GAAP.

Forward-Looking Statement

This release contains forward-looking statements, which are made pursuant to and in reliance upon the safe harbor provisions of federal securities laws,

including the Private Securities Litigation Reform Act of 1995, Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Investors are cautioned that statements in this

release which are not strictly historical statements, including, among others; any express or implied statements or guidance regarding current or future financial performance and position, including our year 2024 financial guidance and related

assumptions; expected demand in the markets in which we operate (including the belief that such markets will improve and the impact of such improvement on our business); the expected performance of our business; planned efficiencies and results from

our restructuring and rebalancing activities; the expected performance and success of our strategic partnerships and integration of our acquired businesses, constitute forward-looking statements identified by words like believe,

expect, may, will, should, seek, anticipate, projected, estimated or could and similar expressions. Forward-looking statements are neither

historical facts nor assurances of future performance. Because forward-looking statements relate to the future, they are subject to a number of risks and uncertainties that could cause actual results to differ materially from those anticipated,

including, risks associated with our restructuring activities and our ability to successfully rebalance our organization; our ability to successfully grow our bioprocessing business; our ability to manage through and predict headwinds, including to

achieve our adjusted 2024 financial guidance; our ability to develop and commercialize products and the market acceptance of our

products; our ability to successfully integrate any acquired businesses (including Metenova and FlexBiosys) into our business and achieve the expected benefits of such acquisitions; that demand

for our products could continue to decline, which could adversely impact our future revenues, cash flows, results of operations and financial condition; our ability to compete with larger, better financed bioprocessing, pharmaceutical and

biotechnology companies; our compliance with all U.S. Food and Drug Administration and European Medicines Evaluation Agency regulations; the lasting effects of COVID-19 on our business operations and the

operations of our customers and suppliers; our volatile stock price; and other risks detailed in Repligen s filings with the U.S. Securities and Exchange Commission (the Commission), including Annual Report on Form 10-K for the year ended December 31, 2022 and in subsequently filed reports with the Commission, including our Quarterly Reports on Form 10-Q and current reports on Form 8-K, as well as our upcoming Annual Report on Form 10-K for the year ended December 31, 2023. Actual results may differ materially from those Repligen contemplated by

these forward-looking statements; therefore, you should not rely on any of these forward-looking statements. These forward-looking statements reflect management s current views, expectations, and assumptions regarding the future of our

business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions, and are based only on information currently available to us. Repligen does not undertake to update, whether written or oral,

any of these forward-looking statements to reflect a change in its views or events or circumstances, whether as a result of new information, future development or otherwise, that occur after the date hereof except as required by law.

Global Head of Investor Relations

REPLIGEN CORPORATION

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(Unaudited, amounts in thousands, except share and per share data)

REPLIGEN CORPORATION

RECONCILIATIONS OF GAAP to NON-GAAP FINANCIAL MEASURES

(Unaudited, amounts in thousands, except percentage and per share data)

Reconciliation of Reported Revenue Growth to Organic Revenue Growth (Non-GAAP)

Reconciliation of Total Revenue (GAAP) to Base Revenue (Non-GAAP)

Reconciliation of GAAP (Loss) Income from Operations to Adjusted Income from Operations

Reconciliation of GAAP Net (Loss) Income to Adjusted Net Income

Reconciliation of GAAP (Loss) Earnings Per Share to Adjusted Earnings Per Share

Reconciliation of GAAP Net (Loss) Income to Adjusted EBITDA

Reconciliation of GAAP Cost of Sales to Adjusted Cost of Sales (Non-GAAP)

Reconciliation of GAAP R&D Expense to Adjusted R&D Expense (Non-GAAP)

Reconciliation of GAAP SG&A Expense to Adjusted SG&A Expense

Reconciliation of GAAP Net Income Guidiance to Adjusted Net Income (Non-GAAP)