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Dr. Reddy's Laboratories Ltd. 8-2-337, Road No. 3, Banjara Hills, Hyderabad - 500 034, Telangana, India. CIN : L85195TG1984PLC004507 Tel : +91 40 4900 2900 Fax : +91 40 4900 2999 Email : mail@drreddys.com www.drreddys.co

Key Takeaway: Dr. Reddy's Laboratories has received a Complete Response Letter from the USFDA regarding its Biologics License Application for the biosimilar rituximab candidate, DRL_RI. This response stems from ongoing issues related to the inspection of their Biologics manufacturing facility in Hyderabad. The company emphasizes that this development does not affect the manufacturing or development of existing products. Dr. Reddy's intends to work closely with the USFDA to resolve the concerns and expedite the availability of the biosimilar to U.S. patients.

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CONCERNS & RISKS

  • The USFDA issued a Complete Response Letter (CRL) for the Biologics License Application.
  • Ongoing observations from the inspection of the Biologics facility in October 2023 remain unresolved.
  • Certain aspects pertaining to the BLA need addressing, which may delay approval.

Full Press Release Details

National Stock Exchange of India Ltd. (Scrip Code:
BSE Limited (Scrip Code: 500124)
New York Stock Exchange Inc. (Stock Code: RDY)
NSE IFSC Ltd. (Stock Code: DRREDDY)
Sub: Intimation under Regulation 30 of the SEBI
(Listing Obligations and Disclosure Requirements) Regulations, 2015
In furtherance to our intimation dated October 12,
2023, on the Pre-Approval Inspection (PAI) at our Biologics manufacturing facility in Bachupally, Hyderabad, and our announcement dated
July 12, 2023, on the acceptance of the Biologics License Application (BLA) of our proposed biosimilar rituximab candidate DRL_RI, we
would like to inform you that the United States Food and Drug Administration (USFDA) has issued a Complete Response Letter (CRL) to our
BLA. The CRL is in reference to ongoing resolution of observations arising from the inspection of our Biologics facility in October 2023,
as well as certain aspects pertaining to the BLA.
This has no impact on the development or manufacturing
of any current commercial or pipeline product.
We will continue to work closely with the USFDA to
address and resolve all concerns within stipulated timelines in order to make this biosimilar rituximab available to patients in the U.S.
as soon as possible.
This is for your information and records.
For Dr. Reddy's Laboratories Limited
Company Secretary, Compliance Officer & Head-CSR

Frequently Asked Questions

What is the recent regulatory update for Dr. Reddy's Laboratories?

Dr. Reddy's received a Complete Response Letter from the USFDA regarding its BLA for the biosimilar DRL_RI.

How does the CRL affect Dr. Reddy's current products?

The CRL does not affect the development or manufacturing of any existing products.

What is the focus of ongoing actions with the USFDA?

The focus is on resolving observations from a recent facility inspection and BLA aspects.

When was the Pre-Approval Inspection conducted?

The Pre-Approval Inspection at the manufacturing facility took place in October 2023.

What is the goal for the biosimilar rituximab candidate?

The goal is to resolve issues quickly to offer the biosimilar to U.S. patients soon.

Last updated: Apr 20, 2024