Full-Thickness Skin Defects ("FTSD") Market Sizing - June 2023 Update Market Size Additional Market Opportunity (1) (1) Prior to FDA Approval with FDA Approved Expanded Indication of FTSD Traumatic Wounds Traumatic Wound

Sizing - June 2023 Update Market Size Additional Market Opportunity (1) (1) Prior to FDA Approval with FDA Approved Expanded Indication of FTSD Traumatic Wounds Traumatic Wounds Surgical Wounds Data Degloving (Open Wounds) 99,000

Gun Shot Wounds Muscle-only Flap pending Data Crush 2,000 Traumatic Hematoma Laparotomy pending Abrasion 5,000 Abdominoplasty Dehiscence Laceration 10,000 Hidradenitis

Suppurativa Puncture 2,000 Chronic Wounds Surgical Excision - Cancer Surgical Wounds DFU 21,000 Cancer Excision 136,000 Necrotizing Fasciitis 2,000 VLU 42,000 Amputation 6,000 Non -

Pressure Ulcers 51,000 Fasciotomy 1,000 Pressure Ulcers 14,000 ~127,000 Eligible Procedures > 264,000 Eligible Procedures Total Market Opportunity of Traumatic, Surgical, Cancer Excision & Chronic Wounds ~391,000 Annual