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Rani Therapeutics and ProGen Announce Late Breaking Presentation at ENDO 2025 Demonstrating Bioequivalence of Novel, Bispecific GLP-1/GLP-2 Receptor Agonist Delivered Orally via RaniPill Compared to Subcutaneous Delivery

Key Takeaway: Rani Therapeutics announced a late-breaking presentation at ENDO 2025, showcasing preclinical data on its RaniPill capsule. The study demonstrated bioequivalence of a bispecific GLP-1/GLP-2 receptor agonist delivered orally compared to subcutaneous injection in canines. This advancement highlights Rani's commitment to developing innovative oral delivery systems for biologics.
Price reaction · baseline $0.644 (2025-07-11 close) · hit pre-market · 1 other RANI headline(s) in the window, move may be shared
day 0 close
+8.4%
day 1
-33.8%
day 3 · peak
-35.3%

Market Sentiment Analysis

POSITIVE FACTORS

  • Successful presentation of preclinical data at ENDO 2025.
  • Demonstration of bioequivalence of a novel oral delivery system.
  • Potential to replace subcutaneous injections with oral dosing.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Cash runway
~18 mo
Low dilution risk
Lead asset
Stelara
Phase 1 · Healthy Volunteers

Full Press Release Details

SAN JOSE, Calif., July 14, 2025 (GLOBE NEWSWIRE) -- Rani Therapeutics Holdings, Inc. (“Rani Therapeutics” or “Rani”) (Nasdaq: RANI), a clinical-stage biotherapeutics company focused on the oral delivery of biologics and drugs, today announced that it will present preclinical data on the RaniPill® capsule at the Endocrine Society’s Annual Meeting (ENDO 2025) taking place July 12-15 in San Francisco, CA.
Details of the presentations are as follows:
Abstract Title:Oral Delivery of a Bispecific GLP-1/GLP-2 Receptor Agonist (PG-102) via a Robotic Pill (RT-114) Achieves Bioequivalence to Subcutaneous Injection in Canines

Session Type:Poster Presentation

Session Title:Adipose Tissue, Appetite, and Obesity: From Breakthroughs to Real-World Challenges: Navigating Weight Loss, Regain, and Therapeutic Advances II

Session Date & Time:July 14, 2025 from 12:00 PM to 1:30 PM PT

Poster Number:MON-691

Presenting Author:Anvesh Dasari, PhD

The abstract presented at ENDO 2025 is available on the Endocrine Societywebsite.

About Rani Therapeutics

Rani Therapeutics is a clinical-stage biotherapeutics company focused on advancing technologies to enable the development of orally administered biologics and drugs. Rani has developed the RaniPill® capsule, which is a novel, proprietary and patented platform technology, intended to replace subcutaneous injection or intravenous infusion of biologics and drugs with oral dosing. Rani has successfully conducted several preclinical and clinical studies to evaluate safety, tolerability and bioavailability using RaniPill® capsule technology. For more information, visit ranitherapeutics.com.

Frequently Asked Questions

What is the RaniPill technology?

The RaniPill is a proprietary capsule designed for the oral delivery of biologics, replacing injections.

What was presented at ENDO 2025?

Rani Therapeutics presented preclinical data showing bioequivalence of an oral bispecific GLP-1/GLP-2 agonist.

When did the ENDO 2025 meeting take place?

The ENDO 2025 meeting occurred from July 12-15, 2025, in San Francisco, CA.

Who presented the data at ENDO 2025?

The data was presented by Anvesh Dasari, PhD, during a poster session.

Last updated: Jul 14, 2025